Herbicidal sulfonamides

ABSTRACT

Novel N-(heterocyclicaminocarbonyl) substituted thiophene-, furan- and pyrrolesulfonamides, such as N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-6,7-dihydro-5H-thieno-[3,2-b]thiopyran-3-sulfonamide, 4,4-dioxide and N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-6,7-dihydro-5H-thieno[3,2-b]thiopyran-3-sulfonamide, 4,4-dioxide and their method-of-use as herbicides are described.

RELATED APPLICATIONS

This application is a continuation-in-part of my copending applicationU.S. Ser. No. 660,233 filed Oct. 17, 1984 which, in turn, is acontinuation-in-part of my application U.S. Ser. No. 551,943 filed onNov. 15, 1983 both now abandoned.

BACKGROUND OF THE INVENTION

The invention relates to novel N-(heterocyclicaminocarbonyl) substitutedthiophenesulfonamides which are useful as herbicides, and theirmethod-of-use as general pre-emergence or post-emergence herbicides orplant growth regulants.

In U.S. Pat. No. 4,127,405, issued Nov. 28, 1978 to Levitt, herbicidalbenzene- and thiophenesulfonylureas are disclosed.

U.S. Pat. No. 4,398,939, issued Aug. 16, 1983 to Levitt disclosesherbicidal thiophenesulfonylureas substituted by alkyl, OCH₃, NO₂,halogen, or sulfamoyl groups.

European Patent Application (EP-A)-30,142, published June 10, 1981teaches herbicidal thiophenesulfonylureas bearing ortho-carboxylic acidester groups as well as other derivatives of carboxylic acids.

European Patent Application (EP-A)-64,804, published Nov. 17, 1982,discloses herbicidal thiophenesulfonylureas bearing ortho-alkylsulfonylgroups.

U.S. Pat. No. 4,319,627, issued July 5, 1983 to Levitt disclosesbenzothiophenesulfonylureas.

European Patent Application (EP-A)-79,683, published May 25, 1983,teaches herbicidal sulfonylureas including those of the generalformulae: ##STR1## wherein Q is O, S or SO₂ ;

R₂ is H or C₁ -C₃ alkyl;

R₃ is H or CH₃ ; and

R₄ is H or CH₃.

EPA-107,979, published May 9, 1984, teaches herbicidal sulfonylureasincluding those of the general formulae: ##STR2## wherein ##STR3## n is0, 1 or 2; G is O or NR"; and

R" is alkyl.

South African Patent Application No. 83/5165 (Swiss priority 7/16/82,published 1/16/84) discloses herbicidal sulfonamides of formula ##STR4##wherein

A is an unsubstituted or substituted bridge of 3 or 4 atoms whichcontains 1 or 2 oxygen, sulfur or nitrogen atoms and, together with thelinking carbon atom, forms a non-aromatic 5- or 6-membered heterocyclicring system, with the proviso that two oxygen atoms are separated by atleast one carbon atom and that oxygen and sulfur atoms are only linkedto each other if the sulfur atom takes the form of the --SO-- or SO₂ --group.

SUMMARY OF THE INVENTION

This invention relates to novel compounds of Formula I, suitableagricultural compositions containing them and their method-of-use asgeneral preemergence and/or postemergence herbicides or plant growthregulants. ##STR5## wherein J is ##STR6## E is a bridge of 3 or 4 atoms,which may be substituted or unsubstituted, containing 0-2 heteroatomsselected from the group consisting of oxygen, sulfur and nitrogen andalso containing 1-4 atoms of carbon, said bridge together with twocarbon attachment sites forming a partially saturated 5 to 6 memberedcarbocyclic or heterocyclic ring; or E is a bridge of 3 or 4 atoms whichmay be substituted or unsubstituted containing at least 1 heteroatomselected from 0-1 oxygen or sulfur or 0-2 nitrogen and 1-3 atoms ofcarbon, said bridge together with two carbon attachment sites forming anunsaturated 5 to 6 membered heterocyclic ring, with the proviso thatwhen E contains two atoms of oxygen or sulfur, then they must beseparated by at least one atom of carbon and that oxygen and sulfur areonly linked to each other if the sulfur is in the form of SO or SO₂ ; inthe bridging group E, nitrogen may take the form of N or N--O, sulfurmay take the form of S, SO or SO₂, and one of the atoms of carbon may bea carbonyl, thiocarbonyl or the cyclic 5 and 6 membered ketals thereof;when one of the bridging atoms is a substituted carbon, the substituenton said carbon includes H, halogen, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₃-C₄ alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl, C₃ -C₄ haloalkynyl, C₁-C₃ alkoxycarbonyl, CN, NO₂, OH, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy, C₁-C₃ alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, C₁ -C₃alkylcarbonyl, C₁ -C₃ alkylsulfamoyl, di(C₁ -C₃ alkyl)sulfamoyl and C₁-C.sub. 2 alkyl substituted with C₁ -C₂ alkoxy, C₁ -C₂ alkylthio or CN;when the bridging atom is a nitrogen (other than nitrogen in the form ofR₆ NSO₂ in J₇, J₈, J₁₁ and J₁₂) substituents on said nitrogen include H,C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₃ -C₄ alkenyl, C₃ -C₄ haloalkenyl, C₃-C₄ alkynyl, C₃ -C₄ haloalkynyl, C₁ -C₃ alkoxy, C₁ -C₄ alkylcarbonyl, C₁-C₃ alkoxycarbonyl, C₁ -C₃ alkylaminocarbonyl or C₁ -C₄ alkylsulfonyl;when the bridging atom is a nitrogen, in the form of R₆ NSO₂ as in J₇,J₈, J₁₁ and J₁₂, the nitrogen substituents are as defined for R₆.

G is O, S, NH or NCH₃ ;

W is O or S;

R is H or CH₃ ;

R₁ is H, F, Cl, Br, NO₂, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, C₁ -C₃ alkoxy,C₁ -C₃ haloalkoxy, S(O)_(p) C₁ -C₃ alkyl, S(O)_(p) C₁ -C₃ haloalkyl, CO₂(C₁ -C₃ alkyl), CO₂ (C₁ -C₃ haloalkyl), OCH₂ CH═CHR_(a), OCH₂C.tbd.CR_(a), CO₂ (CH₂ CH═CHR_(a)), CO₂ (CH₂ C.tbd.CR_(a)) or SO₂ NR_(b)R_(c) ;

R₁ ' is H, CH₃, F or Cl;

p is 0, 1 or 2;

R_(a) is H or CH₃ ;

R_(b) is H, C₁ -C₃ alkyl or C₁ -C₃ haloalkyl;

R_(c) is H, C₁ -C₃ alkyl or C₁ -C₃ haloalkyl;

A is ##STR7## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁-C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃ alkyl)amino;

Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂ -C₅alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di-(C₁ -C₃ -alkyl)amino, C₃ -C₄alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylthioalkyl, C₂ -C₅alkylsulfinylalkyl, C₂ -C₅ alkylsulfonylalkyl, C₁ -C₄ haloalkyl, C₃ -C₅cycloalkyl, C₂ -C₄ alkynyl, ##STR8## or N(OCH₃)CH₃ ;

W₁ and W'₁ are independently O or S;

m is 2 or 3;

R_(d) is H or CH₃ ;

R_(e) is C₁ -C₂ alkyl;

R_(f) is C₁ -C₂ alkyl;

Z is CH, N, CCH₃, CC₂ H₅, CCl or CBr;

Z₁ is CH or N;

Y₁ is O or CH₂ ;

X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₂ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, OCF₂ H, SCF₂ H, CH₃ or CH₂ CH₃ ;

X₃ is CH₃ or OCH₃ ;

Y₃ is H or CH₃ ;

X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl; and

Y₄ is CH₃, OCH₃ or OC₂ H₅ ;

Exemplary values of J include ##STR9## Q is O, S, SO, SO₂, CH₂ or CHCH₃; Q₁ is O, S, CH₂ or NR₄ ;

W₂ is O or S;

R₂ is H, F, Cl or C₁ -C₄ alkyl;

R₃ is H, F, Cl or CH₃ ;

R₄ is H or C₁ -C₄ alkyl;

R₅ is H or CH₃ ;

R₆ is H, R₈, SR₈, SO₂ R₈, OR₈, C(O)R₈, C(O)L, (CO)₂ OR₈, (CO)₂ R₈,C(O)NR₉ R₁₀, C(O)NRA, C(S)SR₈, NH₂, NR₉ R₁₀, OH, CN, P(O)R₁₁ R₁₂,P(S)R₁₁ R₁₂ or Si(CH₃)₂ R₁₃ ;

R₇ is H, C₁ -C₆ alkyl, Cl, Br, CN, NO₂, SR₁₃, SO₂ R₁₃, CO₂ R₁₃ orC(O)R₁₃ ;

R₈ is C₁ -C₁₀ alkyl, C₁ -C₁₀ alkoxyalkoxyalkyl, C₂ -C₁₀ alkenyl, C₂ -C₁₀epoxyalkyl, C₂ -C₁₀ alkynyl, C₃ -C₆ cycloalkyl, C₄ -C₇ cycloalkylalkylor phenyl optionally substituted with R₁₄ ; when R₈ is C₃ -C₆ cycloalkylor C₄ -C₇ cycloalkylalkyl, it may optionally be substituted by C₁ -C₄alkyl, 1 to 3 atoms of Cl or F or 1 Br; when R₈ is C₁ -C₁₀ alkyl, C₂-C₁₀ alkenyl or C₂ -C₁₀ alkynyl, it may optionally be substituted by oneor more halogens and/or by (R₁₅)_(r) provided that when r is 2, thevalues of R₁₅ may be identical or different;

R₉ is H or C₁ -C₄ alkyl;

R₁₀ is H, C₁ -C₁₀ alkyl, C₁ -C₁₀ haloalkyl, C₂ -C₁₀ alkenyl, C₂ -C₁₀alkynyl, C₃ -C₆ cycloalkyl or phenyl substituted with R₁₄ ;

R₁₁ and R₁₂ are independently C₁ -C₄ alkyl, C₁ -C₄ alkoxy or C₁ -C₄alkylthio;

R₁₃ is C₁ -C₁₀ alkyl, benzyl or phenyl optionally substituted with R₁₄ ;

R₁₄ is H, F, Cl, Br, CH₃, OCH₃, NO₂, CN, SCH₃, SO₂ CH₃ or CF₃ ;

R₁₅ is OR₁₀, OC(O)R₁₀, OC(O)NR₉ R₁₀, OSO₂ R₁₀, OP(O)R₁₁ R₁₂, OSi(CH₃)₂R₁₃, SR₁₀, SOR₁₀, SO₂ R₁₀, SCN, CN, SP(O)R₁₁ R₁₂, SP(S)R₁₁ R₁₂, P(O)R₁₁R₁₂, P(S)R₁₁ R₁₂, NR₉ R₁₀, N⁺ R₉ R₁₀ R₁₃, NR₉ C(O)R₁₀, NR₉ C(O)OR₁₀, NR₉C(O)NR₉ R₁₀, NR₉ SO₂ R₁₀, NR₉ P(O)R₁₁ R₁₂, NR₉ P(S)R₁₁ R₁₂, NO₂,C(O)R₁₀, C(O)OR₁₀, C(O)NR₉ R₁₀, C(R₁₀)═NOR₁₂, naphthyl, L, phenyloptionally substituted with R₁₄ and/or R₁₆, ##STR10## R₁₆ is H, F, Cl,Br, phenoxy optionally substituted with R₁₄, or phenyl optionallysubstituted with R₁₄ ;

R₁₇ is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₃ alkoxycarbonyl, F, Cl orCN;

R₁₈ is H, CH₃, C₁ -C₃ alkoxy, F, Cl or OH; or

R₁₇ and R₁₈ may be taken together to form --OCH₂ CH₂ O-- or --OCH₂ CH₂CH₂ O--;

R₁₉ is H or C₁ -C₄ alkyl;

R₂₀ is H or CH₃ ;

R₂₁ and R₂₂ are independently H or CH₃ ;

R₂₃ is C₁ -C₄ alkyl;

R₂₄ is H, F, Cl, C₁ -C₃ alkyl or C₁ -C₃ alkoxy;

R₂₅ is H, F, Cl or C₁ -C₃ alkyl;

R₂₆ is H, F, Cl or C₁ -C₂ alkyl;

R₂₇ is H, F, Cl or CH₃ ;

R₂₈ is H, C₁ -C₄ alkyl, Cl, Br, CN, NO₂, C₁ -C₃ alkylthio, C₁ -C₃alkylsulfonyl, C₁ -C₃ alkoxycarbonyl or C₁ -C₃ alkylcarbonyl;

R₂₉ is H, CH₃, Cl or Br;

R₃₀ is H, CH₃, Cl or Br;

R₃₁ is H or CH₃ ;

R₃₂ is H or C₁ -C₄ alkyl;

R₃₃ is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkylthio, F or Cl;

L is a 5- or 6-membered aromatic heterocycle, a 5- or 6-membereddihydroaromatic heterocycle or a 5- or 6-membered tetrahydroaromaticheterocycle which contains 1-4 heteroatoms selected from 0-1 oxygenatoms, 0-1 sulfur atoms and/or 0-4 nitrogen atoms, with the proviso thatoxygen and sulfur are only linked to each other if the sulfur is in theform of SO or SO₂, and these heterocycles may optionally be substitutedby 1-4 CH₃, 1-2 OCH₃, SCH₃, Cl, N(CH₃)₂ or CN groups or L is a 5- or6-membered lactone, lactam or cycloalkanone which may optionally besubstituted by 1-4 CH₃ groups;

n is 0 or 1;

p' is 0, 1 or 2;

q is 0 or 1; and

r is 1 or 2;

provided that

(a) when W is S, then R is H, A is A-1, Z is CH or N, and Y is CH₃,OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH,OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR11## (b) the total number of carbonatoms in R₂ and R₃ is less than or equal to 4;

(c) when X is Cl, F, or Br, then Z is CH and Y is OCH₃, OC₂ H₅, NH₂,NHCH₃, N(CH₃)₂ or OCF₂ H;

(d) when J is J₁ or J₂, then R₂ and R₃ are other than F or Cl;

(e) the total number of carbons atoms in R₄ and R₅ is less than or equalto 4;

(f) the total number of carbon atoms in R₆ is less than or equal to 13;

(g) when J is J₅, J₆, J₂₇, J₂₈, J₂₉, J₃₀, J₃₁, J₃₂, J₃₃, J₃₄, J₄₁, J₄₂,J₄₃ or J₄₄ and n is 0, then R₄ and/or R₅ is H;

(h) when J is J₆₁ or J₆₂ and n is 0, then R₄ is H or CH₃ ;

(i) when X or Y is OCF₂ H, then Z is CH;

(j) when R₁₇ is C₁ -C₃ alkoxy, then R₁₈ is H, CH₃ or C₁ -C₃ alkoxy; andwhen R₁₈ is C₁ -C₃ alkoxy, then R₁₇ is not F, or Cl;

(k) when R₁₈ is OH, then R₁₇ is H or C₁ -C₃ alkyl; and

(l) when the total number of carbon atoms of X and Y is greater thanfour, then the number of carbon atoms of R₁ is less than or equal totwo, and the number of carbon atoms of R₆ is less than or equal to four;

and their agriculturally suitable salts.

In the above definitions, the term "alkyl", used either alone or incompound words such as "alkylthio" or "haloalkyl", denotes straightchain or branched alkyl, e.g. methyl, ethyl, n-propyl, isopropyl or thedifferent butyl, pentyl, hexyl, heptyl, octyl, nonyl or decyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propyloxy, isopropyloxy and thedifferent butyl, pentyl, hexyl, heptyl, octyl or nonyl isomers.

Alkenyl denotes straight chain or branched alkenes, e.g. vinyl,1-propenyl, 2-propenyl, 3-propenyl and the different butenyl, pentenyl,hexenyl, heptenyl, octenyl, nonenyl or decenyl isomers.

Alkynyl denotes straigth chain or branch alkynes, e.g. ethynyl,1-propynyl, 2-propynyl and the different butynyl, pentynyl, hexynyl,heptynyl, octynyl, nonynyl and decynyl isomers.

Alkylcarbonyl denotes e.g. acetyl, propionyl, and the different butyryl,pentanoyl, hexanoyl, heptanoyl, octanoyl and nonanoyl isomers.

Alkoxycarbonyl denotes e.g. methoxycarbonyl, ethoxycarbonyl,propoxycarbonyl isopropoxycarbonyl and the different butyloxy-,pentyloxy-, hexyloxy-, heptyloxy- and octyloxycarbonyl isomers.

Alkylsulfonyl denotes methylsulfonyl, ethylsulfonyl and the differentpropylsulfonyl, butylsulfonyl, pentylsulfonyl, hexylsulfonyl,heptylsulfonyl, octylsulfonyl and nonylsulfonyl isomers.

Alkylthio, alkylsulfinyl, alkylamino, alkylsulfamoyl, etc. are definedanalogously to the above examples.

Cycloalkyl denotes cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl.

The term "halogen", either alone or in compound words such as"haloalkyl", denotes fluorine, chlorine, bromine or iodine.

The total number of carbon atoms in a substituent group is indicated bythe C_(i) -C_(j) prefix where i and j are numbers from 1 to 10. Forexample, C₁ -C₃ alkylsulfonyl would designate methylsulfonyl throughpropylsulfonyl, C₂ alkoxyalkoxy would designate OCH₂ OCH₃, C₂ cyanoalkylwould designate CH₂ CN and C₃ cyanoalkyl would designate CH₂ CH₂ CN andCH(CN)CH₃.

PREFERRED COMPOUNDS

Preferred for reasons of greater ease of synthesis and/or greaterherbicidal efficacy are:

1. Compounds of Formula I where J is J₁ -J₁₆₆.

2. Compounds of Preferred 1 where

R is H;

W is O; and

G is O or S.

3. Compounds of Preferred 2 where

X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, I, OCF₂ H, CH₂ F, CF₃, OCH₂ CH₂ F,OCH₂ CHF₂, OCH₂ CF₃, CH₂ Cl or CH₂ Br; and

Y is H, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CH₂CH₃, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, CH₂ OCH₂ CH₃, OCH₂ CH₂ OCH₃,CH₂ SCH₃, CH₂ SCH₂ CH₃, ##STR12## OCF₂ H, SCF₂ H, C.tbd.CH or C.tbd.CCH₃; 4. Compounds of Preferred 3 wherein:

G is S;

R₁ is H, Cl, Br or CH₃ ;

R₂ and R₄ are H or C₁ -C₃ alkyl;

R₃ is H or CH₃ ;

R₆ is H, R₈, C(O)R₈ or CO₂ R₈ ;

R₇ is H, C₁ -C₂ alkyl, Cl, Br, SC₁ -C₂ alkyl, SO₂ C₁ -C₂ alkyl, CO₂ C₁-C₂ alkyl or C(O)C₁ -C₂ alkyl;

R₈ is C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂ -C₆ alkenyl, C₂ -C₆haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ epoxyalkyl or C₁ -C₄ alkylsubstituted with C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂ alkylsulfinyl,C₁ -C₂ alkylsulfonyl, CO₂ (C₁ -C₂ alkyl), C(O)C₁ -C₂ alkyl, CN or OH.

R₁₇ is H, C₁ -C₃ alkyl, C₁ -C₂ alkoxy or C₁ -C₂ alkoxycarbonyl;

R₁₈ is H, CH₃, C₁ -C₂ alkoxy or OH; or R₁₇ and R₁₈ may be taken togetherto form --OCH₂ CH₂ O-- or --OCH₂ CH₂ CH₂ O--;

R₂₈ is H, C₁ -C₃ alkyl, Cl, Br or NO₂ ; and

R₃₃ is H or CH₃.

5. Compounds of Preferred 4 wherein R₈ is C₁ -C₆ alkyl, C₁ -C₄haloalkyl, C₃ -C₄ alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl, or C₁ -C₃alkyl substituted with C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂alkylsulfonyl, CN, C(O)C₁ -C₂ alkyl or CO₂ (C₁ -C₂ alkyl).

6. Compounds of Preferred 5 where

A is A-1;

Z is CH or N;

X is CH₃, OCH₃, OCH₂ CH₃, Cl, OCF₂ H or OCH₂ CF₃ ; and

Y is CH₃, OCH₃, C₂ H₅, CH₂ OCH₃, NHCH₃ or CH(OCH₃)₂ ;

7. Compounds of Preferred 6 where J is J₁ or J₂.

8. Compounds of Preferred 6 where J is J₃ or J₄.

9. Compounds of Preferred 6 where J is J₅ or J₆.

10. Compounds of Preferred 6 where J is J₇ or J₈.

11. Compounds of Preferred 6 where J is J₉ or J₁₀.

12. Compounds of Preferred 6 where J is J₁₁ or J₁₂.

13. Compounds of Preferred 6 where J is J₁₃ or J₁₄.

14. Compounds of Preferred 6 where J is J₁₅.

15. Compounds of Preferred 6 where J is J₂₃.

16. Compounds of Preferred 6 where J is J₂₅.

17. Compounds of Preferred 6 where J is J₂₇.

18. Compounds of Preferred 6 where J is J₃₅, J₃₇ or J₃₉.

19. Compounds of Preferred 6 where J is J₄₁.

20. Compounds of Preferred 6 where J is J₆₉ or J₇₁.

21. Compounds of Preferred 6 where J is J₇₉.

22. Compounds of Preferred 6 where J is J₈₇.

23. Compounds of Preferred 6 where J is J₉₅.

24. Compounds of Preferred 6 where J is J₁₀₅ or J₁₀₆.

25. Compounds of Preferred 6 where J is J₁₂₇ or J₁₂₉.

26. Compounds of Preferred 6 where J is J₁₃₁ or J₁₃₃.

Specifically Preferred for reasons of their highest herbicidal activity,greatest plant growth regulant activity and/or most favorable ease ofsynthesis are:

N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]6,7-dihydro-5H-thieno[3,2-B]thiopyran-3-sulfonamide,4,4-dioxide, m.p. 224°-225.5° C.

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-6,7-dihydro-5H-thieno[3,2-B]thiopyran-3-sulfonamide,4,4-dioxide, m.p. 228°-230° C.

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-5,6-dihydro-5-methylthieno[3,2-B]-thiophene-3-sulfonamide-4,4-dioxide,m.p. 186°-187° C.

N-[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-5,6-dihydro-5-methylthieno[3,2-B]thiophene-3-sulfonamide-4,4-dioxide,m.p. 192°-193° C.

N-[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]5,6-dihydro-5-methylthieno[3,2-B]thiophene-3-sulfonamide-4,4-dioxide,m.p. 203°-204° C.

DETAILED DESCRIPTION OF THE INVENTION Synthesis

The following discussion represents a general outline for thepreparation of the compounds of this invention. All of the synthesesdescribed below are multistep with one or more methods being taught foreach step. This allows for a wide variety of possible synthetic pathwaysto prepare a particular compound of Formula I. The proper choice of thesynthetic pathway and the best ordering of the reaction sequences foreach individual compound will be known to one skilled in the art.

The compounds of Formula I can be prepared by one or more of the methodsdescribed below in Equations 1 to 6.

As shown in Equation 1, many of the compounds of Formula I can beprepared by reacting a sulfonylisocyanate (W=O) or asulfonylisothiocyanate (W=S) of Formula II with an appropriateheterocyclic amine of Formula III. R, A and W are as previously defined.

EQUATION 1 ##STR13##

The reaction is carried out at 25° to 100° C. in an inert, aproticsolvent such as methylene chloride or xylene for 0.5 to 24 hours astaught in U.S. Pat. No. 4,127,405.

Many of the compounds of Formula I, where W is S and R is H, (Ia) can beprepared by reacting the appropriate sulfonamide of Formula IV with aheterocyclic isothiocyanate of Formula V, as shown in Equation 2.

EQUATION 2 ##STR14##

The reaction is carried out at 25° to 80° C. in an inert, aproticsolvent such as acetone or acetonitrile in the presence of a base suchas potassium carbonate for 0.5 to 24 hours. The required heterocyclicisothiocyanates V are prepared from the corresponding amines III astaught in EPO Publication No. 35,893.

Many of the compounds of Formula I, where W is O (Ib) and J is otherthan J₅, J₆, J₉ and J₁₀, can be prepared by reacting the sulfonamides ofFormula IV with an appropriate methylcarbamate of Formula VI in thepresence of an equimolar amount of trimethylaluminum, as shown inEquation 3.

EQUATION 3 ##STR15##

The reaction is carried out at 25° to 40° C. in a solvent such asmethylene chloride for 10 to 96 hours under an inert atmosphere astaught in EPO Publication No. 82,681. The required carbamates VI areprepared by reacting the corresponding amines III with dimethylcarbonateor methyl chloroformate in the presence of a strong base.

Alternatively, many of the compounds of Formula Ib, can be prepared byreacting a sulfonylcarbamate of Formula VII with an appropriate amine ofFormula III, as shown in Equation 4.

EQUATION 4 ##STR16##

The reaction is carried out at 50° to 100° C. in a solvent such asdioxane for 0.5 to 24 hours as taught in EPO publication No. 44,807. Therequired carbamates VII are prepared by reacting the correspondingsulfonamides IV with diphenylcarbonate in the presence of a strong base,such as sodium hydride.

Compounds of Formula Ib can also be prepared, as shown in Equation 5, byreacting a heterocyclic carbamate of Formula VIII with an appropriatesulfonamide of Formula IV.

EQUATION 5 ##STR17##

The reaction is carried out at 0° to 50° C. in a solvent such asacetonitrile or dioxane in the presence of a non-nucleophilic base suchas DBU for 0.2 to 24 hours. The required phenylcarbamate VIII areprepared by reacting the corresponding heterocyclic amines III withdiphenylcarbonate or phenylchloroformate in the presence of a strongbase, such as sodium hydride.

Many of the compounds of Formula Ib, particularly when G is NH or NCH₃can be prepared by reacting the bicyclic heterocycles IX with asulfamoyl chloride X as shown in Equation 6.

EQUATION 6 ##STR18##

The reaction is carried out at -78° C. to 80° C. in a solvent such astetrahydrofuran or nitroethane for 1 to 48 hours alone or in thepresence of a Friedel-Crafts catalyst as taught in U.S. Pat. Nos.4,368,067 and 4,473,394. The sulfamoyl chloride intermediates X areprepared by reacting the heterocyclic amines III withchlorosulfonylisocyanate by methods taught in U.S. Pat. No. 4,401,816.

The intermediate sulfonylisocyanates (W=O) and sulfonylisothiocyanates(W=S) of Formula II from Equation 1 can be prepared as shown inEquations 7, 8 and 9.

As shown in Equation 7, many of the sulfonylisocyanates of Formula IIawhere J is other than J₃ and J₄ can be prepared by the reaction ofsulfonamides of Formula IV with phosgene, in the presence ofn-butylisocyanate and a tertiary amine catalyst, at reflux in a solventsuch as xylene by the method of U.S. Pat. No. 4,238,621.

EQUATION 7 ##STR19##

The sulfonylisocyanates can also be prepared from the sulfonamides by atwo step procedure involving (a) reacting the sulfonamides withn-butylisocyanate in the presence of a base such as K₂ CO₃ at reflux inan inert solvent such as 2-butanone forming a n-butylsulfonylurea; and(b) reacting this compound with phosgene and a tertiary amine catalystat reflux in xylene solvent. The method is similar to a procedure taughtby Ulrich and Sayigh, Newer Methods of Preparative Organic Chemistry,Vol. VI, p. 223-241, Academic Press, New York and London, W. Foerst Ed.

Alternatively, as shown in Equation 8, many of the sulfonylisocyanatesof Formula IIa can be prepared by reacting the corresponding sulfonylchlorides VIII with cyanic acid salts.

EQUATION 8 ##STR20##

The reaction is carried out at 25° to 100° C. in an inert aproticsolvent such as acetonitrile for 0.5-24 hours in the presence ofphosphorus pentoxide and an alkali metal salt such as lithium iodideaccording to the teachings of Japanese Pat. No. 76/26,816 (Chem. Abst.,85: 77892e (1976)).

Many of the sulfonylisothiocyanates of Formula IIb where J is other thanJ₃ and J₄ can be prepared, as shown in Equation 9, by contacting thesulfonamides of Formula IV with carbon disulfide in the presence of twoequivalents of a strong base. The resulting salt is then reacted withphosgene according to the teachings of K. Hartke, Arch. Pharm., 299, 174(1966).

EQUATION 9 ##STR21##

The sulfonamides of Formula IV of Equations 2, 3, 5, 7 and 9 areimportant intermediates for the preparation of the compounds of thisinvention. The syntheses of the required sulfonamide intermediates aredescribed in Equations 10 to 15.

As shown in Equation 10, sulfonamides of Formula IV can be prepared fromthe corresponding sulfonyl chlorides of Formula XI by contacting witheither anhydrous or aqueous ammonia.

EQUATION 10 ##STR22##

The preparation of sulfonamides from sulfonyl chlorides is widelyreported in the literature, for reviews see: F. Hawking and J. S.Lawrence, "The Sulfonamides," H. K. Lewis and Co., London, 1950 and E.H. Northey, "The Sulfonamides and Allied Compounds," Reinhold PublishingCorp., New York, 1948.

Alternatively, many sulfonamides IV can be prepared by dealkylation oftheir corresponding N-t-butyl sulfonamides XII as shown in Equation 11.

EQUATION 11 ##STR23##

The reaction is carried out by contacting the N-t-butyl sulfonamide XIIwith a strong acid such as trifluoroacetic acid or methanolic HCl at 25°to 50° C. for 0.5 to 24 hours. The N-t-butyl sulfonamides XII arereadily prepared by reacting sulfonylchlorides XI with t-butylamine andare useful either as an aid in purification, to enhance solubility forsubsequent reactions such as Equation 12 below or to protect thesulfonamide function from competing with reactions at other parts of themolecule.

Many of the unsaturated sulfonamides of Formula IVa and IVb can beprepared from the corresponding saturated sulfonamides of Formula IVcand IVd by the two-step procedure shown in Equation 12. G₁ -G₂ is e.g.CO--O, SO₂ --NR₆, CO--NR₄ or O--SO₂ and R" is H or C(CH₃)₃.

EQUATION 12 ##STR24##

The first step involves α-bromination by N-bromosuccinimide to give amonobromide which is subsequently dehydrobrominated in a second step byreaction with a suitable base such as triethylamine orpotassium-t-butoxide in an inert solvent such as THF. This method hasbeen used to prepare isocoumarins from 3,4-dihydroisocoumarins, see R.Barry, Chem. Rev., 64, 229 (1964). In cases where R₁ or R₁ ' is a methylfunction, competitive bromination at this site may occur resulting in amixture. The desired bromide may be separated at this stage, or aftertreatment with the base, by standard methods.

Many of the sulfonamides of Formula IVe and IVf can be prepared fromsulfonamides of Formula IVg and IVh, respectively in dehalogenation asshown in Equation 13.

R₁ and R₁ ' are Cl or Br and R" is H or C(CH₃)₃.

EQUATION 13 ##STR25##

A typical dehalogenation method involves contacting the halo compoundwith zinc in aqueous acetic acid at 25° to 100° C. for 0.5 to 24 hours.A variety of dehalogenation methods are known, for example, see H. D.Hartough, Thiophene and Derivatives, Vol. III of The Chemistry ofHeterocyclic Compounds, Interscience, New York, 1952.

Additionally, as shown in Equation 14, many of the sulfonamides ofFormula IVi and IVj can be prepared by oxidation of sulfonamides ofFormula IVk and IVl, respectively. m is 1 or 2. R₁ is not SCH₃ and R" isH or C(CH₃)₃.

EQUATION 14 ##STR26##

The oxidation of sulfides to sulfoxides and sulfones are widely reportedin the literature, for an overview see: "Organic Chemistry of Sulfur",Plenum Press, New York, 1977, S. Oae Ed.

Many of the sulfonamides of Formula IVm and IVn can be prepared byfunctionalization of the corresponding N-unsubstituted sulfonamides ofFormula IVo and IVp, respectively, as shown in Equation 15. G₁ -G₂ is(CH₂)_(n) --CHR₅ or CH═R₅, R" is H or C(CH₃)₃ and X is Cl, Br, I orother readily displaceable groups.

EQUATION 15 ##STR27##

The reaction is carried out by contacting the sulfonamides IVo or IVpwith the appropriate electrophile in the presence of a suitable basesuch as K₂ CO₃ in an inert, polar solvent such as DMF at 0° to 100° C.for 0.5 to 24 hours. In some instances the R₆ function can also beintroduced by Michael addition of IVo or IVp to the appropriate Michaelacceptor as known to one skilled in the art.

While many of the R₆ groups can be introduced directly, as describedabove, some of the R₆ groups may best be prepared by standard Functionalgroup manipulations upon compounds of Formula IVm or IVn containing anappropriate R₆ group precursor as will be known to one skilled in theart. Some examples of these manipulations are the preparation of IVm orIVn where R₆ contains an epoxide by the expoxidation of IVm or IVn whereR₆ contains a carbon-carbon double bond, the preparation of IVm or IVnwhere R₆ contains a sulfone by the oxidation of IVm or IVn where R₆contains a thioether function, the preparation of IVm or IVn where R₆contains OC(O)CH₃ by acetylation of IVm or IVn where R₆ contains OH, orthe preparation of IVm or IVn where R₆ contains NH₂ by the reduction ofIVm or IVn where R₆ contains NO₂.

The sulfonyl chlorides of Formula XI of Equations 8 and 10 can beprepared by methods outlined in Equations 16 to 19.

As shown in Equation 16, many of the sulfonyl chlorides of Formula XIaand XIb can be prepared from the bicyclic heterocycles of Formula XIIIaand XIIIb, respectively by direct chlorosulfonation. R₁ is not H.

EQUATION 16 ##STR28##

Direct chlorosulfonation can be carried out by standard methods such asthose cited by Hartough (loc. cit.) for the preparation of thiophenesulfonylchlorides. For compounds of Formula XIIIa, R₁ cannot be hydrogenin order to avoid chlorosulfonation at the more reactive 2-position ofthe heterocyclic ring. For compounds of Formula IXb, mixtures may resultwhen R₁ ' is hydrogen due to competitive chlorosulfonation at the5-position of the heterocyclic ring. These isomers can be separated bystandard fractional crystallization, fractional distillation orchromatographic methods.

When G is NH or NCH₃, direct ring sulfonation with pyridine-sulfurtrioxide complex may be preferable as known to one skilled in the art.The resulting sulfonic acid can be converted to the sulfonyl chloridesby standard methods.

Alternatively, many of the sulfonyl chlorides of Formula XIa and XIb canbe prepared from compounds of Formula XIIIa and XIIIb by the four stepsequence shown in Equation 17.

EQUATION 17 ##STR29##

Nitration of compounds can be carried out by standard methods such asthose cited by Hartough (loc. cit.) for the thiophene ring system. Thesame regioselectivity in nitration is observed as described for thechlorosulfonation of XIIIa and XIIIb (vide supra). The reduction of theintermediate nitro compounds to amines can be carried out by any ofseveral methods as described in Preparative Organic Chemistry, 4thEdition, p. 557-563, John Wiley and Sons, New York and London, G.Hilgetag and A. Martini Ed. Diazotization of the amines with sodiumnitrite in HCl, followed by reaction of the diazonium salt with sulfurdioxide and cupric chloride in acetic acid analogous to the teachings ofYale and Sowinski, J. Org. Chem., 25, 1824 (1960) provides the desiredsulfonyl chlorides.

Alternatively, many of the sulfonyl chlorides can be prepared by amodification of the above procedure whereby the diazotization reactionis carried out in dilute sulfuric acid and the resulting diazonium saltis reacted with sulfur dioxide, HCl and cupric chloride in a cosolventmixture consisting of acetic acid-water (1:1) and an immiscible, inertsolvent such as 1-chlorobutane or methylene chloride at 0°-40° C. for 1to 24 hours.

Many of the sulfonyl chlorides of Formula XIc and XId can also beprepared from the bromoheterocycles XIIIc and XIIId by the three-stepsequence shown in Equation 18. The E bridge must not containfunctionality incompatible with the BuLi.

EQUATION 18 ##STR30##

The compounds are contacted with 1.0 equivalents of n-Buli at -78° C. ina solvent such as THF to give an organo-lithio species via metal-halogenexchange. The lithio species is reacted with sulfur dioxide to give anintermediate sulfinate salt which precipitates and is isolated byfiltration. The salt is dissolved in a solvent such as acetic acid andtreated with a chlorine source such as N-chlorosuccinimide to give thedesired sulfonyl chloride.

As shown in Equation 19, many of the sulfonyl chlorides of formula XIcan be prepared by a two step sequence from compounds of Formula XIIIe.X is Cl or Br, R" is alkl or benzyl. J must not contain fuctionalityincompatible with a mercaptide anion or molecular chlorine.

EQUATION 19 ##STR31##

The halogenated heterocycle XIIIe is contacted with an alkyl or benzylmercaptan in the presence of a base such as K₂ CO₃ or NaH, in a solventsuch as DMF, at 0° to 150° C. for 1 to 24 hours to give an intermediatethioether. The thioether intermediate is oxidatively chlorinated byaddition of molecular chlorine or a chlorine equivalent in the presenceof water at -20° to 80° C. in an aliphatic carboxylic acid solvent suchas propionic acid or an inert organic solvent such as dichloroethane for1 to 24 hours.

The bicyclic heterocycles XIII in equations 16 to 19 are either known orcan be prepared by one skilled in the art of thiophene, furan andpyrrole chemistry. For example, the bicyclic ring systems are accessiblefrom suitably substituted thiophenes, furans or pyrroles by standardchemical manipulation including, but not limited to, alkylation,acylation, oxidation, reduction, addition, elimination, condensation,cyclization, halogenation and/or organometalic reactions. Examples of avariety of E-bridge forming reactions on a benzene nucleus can be foundin EP-A-107,979 and EP-A-79,683. These methods can be adapted for usewith a thiophene, a furan or a pyrrole nucleus as will be known to oneskilled in the art. Alternatively, the bicyclic ring systems can beprepared from suitably substituted 1,4-dicarbonyl compounds by standaarddehydrative cyclizations to form the thiophene, furan or pyrrole nucleusas known to one skilled in the art. The synthesis of 1,4-dicarbonylcompounds and their conversion to thiophenes, furans and pyrroles iswidely reported. The literature on thiophenes, furans and pyrroles isextensive.

In some cases, formation of the E-bridge after the sulfonamidefunctionality is present may be preferable to alter the reactivity ofthe molecule as will be known to one skilled in the art. One example isshown in Equation 20 where behavior of the E-bridge forming reaction isaffected by the presence of the sulfonamide substituent on the thiophenering.

EQUATION 20 ##STR32##

The thioclaisen reaction shown in equation 20a produces the six ringisomer as the major cyclization product while rearrangement of thesulfonamide substituted system in Equation 20b gives predominantly the5-ring isomer as product.

The amines of Formula III in Equations 1 and 4 are also importantintermediates for the preparation of the compounds of this invention andare described below.

The pyrimidines and triazines of Formula (IIIa) to (IIId) below areeither known or can be prepared by obvious methods known to one skilledin the art. ##STR33##

For a review of the synthesis and reactions of 2-aminopyrimidines (IIIa,Z=CR') see The Chemistry of Heterocyclic Compounds, Vol. 16, John Wileyand Sons, New York (1962). For a review of the synthesis and reactionsof 2-amino-s-triazines (IIIa, Z=N) see The Chemistry of HeterocyclicCompounds, Vol. 13, John Wiley, New York (1959), F. C. Schaefer, U.S.Pat. No. 3,154,547 and F. C. Schaefer and K. R. Huffman, J. Org. Chem.,28 1812 (1963). The synthesis of the bicyclic amines IIIb and IIIc istaught in European Patent Application No. 15,683. The synthesis ofbicyclic amines IIId is taught in European Patent Application No.46,677.

The amines of Formula III where X is OCF₂ H or CF₃ ; or X₁ is OCF₂ Hand/or Y is WCF₂ T wherein W is O or S and T is H, CHClF, CHBrF orCHFCF₃ can be prepared by methods taught in South African PatentApplication No. 82/5045, or by suitable modifications that would beobvious to one skilled in the art.

The pyrimidines or Formula IIIa (Z=CH) where Y is --CR₅ (OCH₃)₂, --CR₅(OCH₂ CH₃)₂, ##STR34## can be prepared according to the methods taughtin European Patent Application No. 84,224 or suitable modificationsthereof known to one skilled in the art.

The triazine amines of Formula IIIe where X₃ is CH₃ or OCH₃ and R is Hor CH₃ can be prepared according to the methods of European PatentApplication No. 94,260. ##STR35##

Preparations of the 3-amino-1,2,4-triazoles of Formula IIIf and thecyanoheterocycles of Formula (IIIg) are described in European PatentApplications Nos. 73,562 and 125,864, respectively.

Many of the aminoheterocyclic intermediates of Formula (III) where R ismethyl may be prepared by a two-step procedure as described for IIIh inEquation 21. X, Y and Z are as previously defined.

EQUATION 21 ##STR36##

A solution of the amine IIIa in concentrated hydrochloric acid istreated with sodium nitrite solution and the chloro compound X isisolated in the usual manner by filtration of the acidic solution. Arepresentative procedure is described by Bee and Rose in J. Chem. Soc.C, 2031 (1966), for the case in which Z=CH, and X=Y=OCH₃. Displacementof the chlorine of X may be accomplished by heating with an excess ofmethylamine in water to obtain the methylamino heterocycle (IIIh).

Agriculturally suitable salts of compounds of Formula I are also usefulherbicides and can be prepared in a number of ways known to the art. Forexample, metal salts can be made by contacting compounds of Formula Iwith a solution of an alkali or alkaline earth metal salt having asufficiently basic anion (e.g., hydroxide, alkoxide, carbonate orhydride). Quaternary amine salts can be made by similar techniques.

Salts of compounds of Formula I can also be prepared by exchange of onecation for another. Cationic exchange can be effected by directcontacting of an aqueous solution of a salt of a compound of Formula I(e.g., alkali metal or quaternary amine salt) with a solution containingthe cation to be exchanged. This method is most effective when thedesired salt containing the exchanged cation is insoluble in water,e.g., a copper salt, and can be separated by filtration.

Exchange may also be effected by passing an aqueous solution of a saltof a compound of Formula I (e.g., an alkali metal or quaternary aminesalt) through a column packed with a cation exchange resin containingthe cation to be exchanged. In this method, the cation of the resin isexchanged for that of the original salt and the desired product iseluted from the column. This method is particularly useful when thedesired salt is water-soluble, e.g., a potassium, sodium or calciumsalt.

Acid addition salts, useful in this invention, can be obtained byreacting a compound of Formula I with a suitable acid, e.g.,p-toluenesulfonic acid, trichloroacetic acid or the like.

In the following examples, all parts are by weight and temperatures arein °C. unless otherwise indicated.

EXAMPLE 1 3-Allylthio-4-bromothiophene

48.4 g (0.20 mol) of 3,4-dibromothiophene was added to a -78° C.solution of 0.21 mol of n-butyllithium (130 mls of a 1.6M solution inhexanes, Aldrich) in 200 mls of anhydrous ether under a nitrogenatmosphere at such a rate that the temperature did not rise above -70°C. The mixture was stirred at -78° C. for 15 minutes and treated with6.4 g (0.21 mol) of elemental sulfur causing the temperature to rise to-50° C. The suspension was recooled to -78° C., stirred for 1 hour,treated with 18.2 g (0.21 mol) of allyl bromide and allowed to warm to20° C. The solution was washed with water and brine, dried over MgSO₄and concentrated to give 47.5 g of an orange oil. 38 g of this oil waschromatographed on 500 g of SiO₂ eluting with hexane to give 30.2 g ofthe desired product as a colorless oil.

90 MHz NMR (CDCl₃): δ 7.4-7.1 (AB, 2H, arom); 6.2-5.6 (m, 1H, vinyl);5.2-4.9 (m, 2H, vinyl); 3.45 (d, 2H, CH₂).

IR (neat) 3100, 1630, 1470, 1320, 980, 930 cm⁻¹.

EXAMPLE 2 3-Bromo-6,7-dihydro-5H-thieno[3,2-b]thiopyran

A solution of 30.2 g (0.13 mol) of 3-allylthio-4-bromothiophene and 10.3mls (0.13 mol) of pyridine in 250 mls of toluene was refluxed for 68hours, cooled, washed with 1N HCl solution, 1N NaOH solution, water andbrine and dried over MgSO₄ and concentrated to give 27.2 g of an amberoil. The oil was chromatographed on 500 g of SiO₂ eluting with hexane togive 16.2 g of the desired product as a colorless oil (90% purity).

90 MHz NMR (CDCl₃): δ 7.15 (s, 1H, arom); 3.1-2.7 (m, 4H, CH₂ 's);2.3-2.0 (m, 2H, CH₂).

IR (neat) 3100, 2920, 1510, 1310, 1110, 960, 900 cm⁻¹.

EXAMPLE 3 6,7-Dihydro-5H-thieno[3,2-b]thiopyran-3-sulfonamide

A solution of 11.8 g (0.05 mol) of3-bromo-6,7-dihydro-5H-thieno[3,2-b]thiopyran in 50 mls of anhydrousether was added dropwise to a solution of 0.055 mol of n-butyllithium(1.6M in hexane) in 100 mls of anhydrous ether such that the temperatureremained below -70° C. The solution was stirred for 15 minutes at -78°C., treated with 3.0 mls (0.07 mol) of liquified SO₂ (exotherm to -50°C.), allowed to warm to 20° C. and stirred for 16 hours. The resultingprecipitate was filtered, washed with ether and hexane and dried to give12.5 g of the sulfinate salt as a cream colored powder, m.p. >300° C.

9.7 g (0.043 mol) of this salt was dissolved in 80 mls of glacial aceticacid and treated with 5.7 g of N-chlorosuccinimide. After 5 minutes, thesolution was poured into ice-water and the resulting precipitate wasfiltered, washed with water and hexane and dried to give 8.15 g of thesulfonyl chloride as a yellow powder, m.p. 80°-87° C.

The sulfonyl chloride was dissolved in 100 mls of methylene chloride andtreated with 2.5 mls of liquified ammonia at -78° C. The mixture waswarmed to 20° C., 100 mls of 1N HCl was added and the methylene chloridephase was separated, washed with brine, dried over MgSO₄ andconcentrated to give 6.2 g of the desired sulfonamide as a white powder,m.p. 146°-149° C.

200 MHz NMR (CDCl₃): δ 7.9 (s, 1H, arom); 4.95 (b, 2H, NH₂); 3.10 (m,2H, CH₂); 2.90 (t, 2H, CH₂); 2.30 (m, 2H, CH₂).

IR (nujol) 3360, 3260, 3100, 1545, 1320, 1150, 960 cm⁻¹.

EXAMPLE 4 6,7-Dihydro-5H-thieno[3,2-b]thiopyran-3-sulfonamide,4,4-dioxide

A suspension of 9.0 g (0.038 mol) of6,7-dihydro-5H-thieno[3,2-b]thiopyran-3-sulfonamide in 200 mls ofmethylene chloride was treated with 2.0 equivalents ofm-chloroperbenzoic acid at -5° C. to 0° C. The mixture was stirred for30 minutes at 0° C., 200 mls of saturated sodium bicarbonate solutionwas added and the methylene chloride layer and suspended solids wereseparated. The methylene chloride layer was concentrated and thecombined solids were washed with water and ether and dried to give 7.8 gof the desired sulfonamide as a white powder, m.p. 213°-215° C.

90 MHz NMR (CDCl₃): δ 8.2 (s, 1H, arom); 7.2 (b, 2H, NH₂); 3.7-2.2 (m,6H, CH₂ 's).

IR (nujol) 3390, 3270, 3100, 1345, 1280, 1150, 1115 cm⁻¹.

EXAMPLE 5N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-6,7-dihydro-5H-thieno[3,2-b]thiopyran-3-sulfonamide,4,4-dioxide

A mixture of 10.5 g (0.039 mol) of6,7-dihydro-5H-thieno[3,2-b]thiopyran-3-sulfonamide-4,4-dioxide, 6.9 gof potassium carbonate and 5.3 ml of n-butyl isocyanate were refluxed in300 mls of dry acetonitrile for 16 hours, cooled and filtered. The solidwas dissolved in water, acidified to pH 3 with concentrated HCl and theresulting precipitate was filtered, washed with water and ether anddried in vacuo at 70° C. to give 10.7 g of the n-butylurea as a creamcolored solid, m.p. 193°-195° C.

A mixture of 10.2 g of the butylurea, 3.1 mls of butyl isocyanate and0.1 g of DABCO were heated in 200 mls of dry xylenes and treated with3.0 ml of liquified phosgene at such a rate that the temperatureremained above 134° C. The mixture was refluxed for 1.5 hours, excessphosgene and HCl were purged with dry nitrogen and the mixture wascooled to 20° C. The resulting solid was filtered under nitrogen andwashed with dry xylenes to give 7.0 g of the sulfonyl isocyanate as alight gray powder, m.p. 216°-230° C., IR 2240 cm⁻¹.

1.4 g of the sulfonyl isocyanate was dissolved in 20 mls of drymethylene chloride and filtered to remove some insolubles. The filtratewas treated with 0.31 g of 2-amino-4,6-dimethoxypyrimidine, heated toreflux for 1 minute and allowed to stir at 20° C. for 1.5 hours. Theresulting precipitate was filtered, washed with dry methylene chlorideand air dried to give 0.37 g of the desired sulfonylurea as a whitepowder, m.p. 228°-230° C.

200 MHz NMR (CDCl₃): δ 12.57 (b, 1H, NH); 8.33 (s, 1H, arom); 7.20 (d,1H, NH); 5.75 (s, 1H, CH); 3.97 (s, 6H, OCH₃ 's); 3.40 (m, 2H, CH₂);3.05 (m, 2H, CH₂); and 2.60 (m, 2H, CH₂).

IR (nujol) 3380, 1720, 1700, 1600, 1445, 1375, 1195, 1155 cm⁻¹.

EXAMPLE 6 4-Bromo-3-thiophenecarboxylic Acid

To 400 ml of dry ether, under nitrogen, cooled to -70° C., was added asolution of 256 ml of n-butyllithium (1.6 m in hexane). A solution of96.8 g of 3,4-dibromothiophene in 600 ml of ether was added, dropwiseover a 20 minute period, maintaining the reaction temperature between-78° C. and -60° C. After stirring for an additional 5 minutes, thesolution was transferred via a double-tipped needle, under nitrogenpressure, to an already prepared solution of 80 g of crushed dry ice in400 ml of ether. The temperature was maintained at below -50° C. duringthis addition. The resulting white mixture was stirred for 5 minutes,quenched with 800 ml of water, and the layers separated. The etherallayer was washed with 500 ml of saturated sodium bicarbonate solution.The aqueous layers were combined and acidified with concentratedhydrochloric acid to yield a white solid which was filtered off andrecrystallized from water/ethanol (5:2) to give 73 g of the titlecompound as needles; m.p. 157°-158° C.

EXAMPLE 7 4-Carboxy-3-thiopheneacetic ethyl ester

A solution of sodium ethoxide was prepared by portionwise addition of16.8 g of sodium pellets, washed free of oil with hexane, to 960 ml ofabsolute ethanol. After all the sodium had reacted, the solution wascooled to 0° C. and 59 ml of ethyl acetoacetate was added dropwise overa 20 minute period. After stirring an additional 5 minutes at 0° C., 64g of 4-bromo-3-thiophenecarboxylic acid and 3.2 g of copper powder wereadded in one portion. The copper colored mixture was refluxed for 7hours, cooled, and poured into 3 l of water. Acidification withconcentrated hydrochloric acid precipitated the product, which wasfiltered off and suction dried. Recrystallization from acetonitrile gave45 g of the title compound as a white cottony solid; m.p. 159°-161° C.

EXAMPLE 8 6,7-dihydro-4H-thieno[(3,4-C)]pyran-4-one

Sodium hydride (50% in oil), was washed free of oil with hexane, andsuspended in 400 ml of dry tetrahydrofuran. To this suspension was added28 g of the compound in the previous example, portionwise. A slightexotherm was noted with concommitant gas evolution. After the gasevolution had ceased, 7.0 g of lithium tetrahydridoborate was added inone portion and the resultant off white mixture was refluxed for 3hours. After cooling, 1 l of water was added followed by carefulacidification with concentrated hydrochloric acid to pH=1. The aqueousmixture was extracted with ether, washed with water and dried overmagnesium sulfate. Evaporation of the solvent, followed by triturationof the crude residue with hexane, gave 20 g of the intermediatehydroxy-acid. To 19 g of this solid dissolved in 1 l of benzene wasadded 1.2 g of para-toluenesulfonic acid and the mixture refluxed, witha Dean Stark trap, for 2 hours. After cooling the benzene solution waswashed with 200 ml of saturated sodium bicarbonate and dried overmagnesium sulfate. Evaporation gave 16 g of the title compound as awhite crystalline solid; m.p. 75°-77° C.

NMR (CDCl₃): ppm 8.25 (s, 1H, ArH); 7.2 (m, 1H, ArH); 4.5 (t, 2H, OCH₂);3.0 (t, 2H, CH₂).

IR (Nujol) 1710 cm⁻¹ (C=O).

EXAMPLE 9 1-Chloro-6,7-dihydro-4H-thieno[(3,4-C)]pyran-4-one

To a solution of 9.0 g of the lactone described in the previous examplein 90 ml of benzene, containing 90 ml of acetic acid, was added 8.3 g ofN-chlorosuccinimide in one portion. The mixture was stirred for 30minutes at room temperature and then brought to reflux for 1 hour. Aftercooling, the reaction mixture was poured into 2 l of water and extractedwith 3×-500 ml portions of ether. The combined ethereal layers werewashed with saturated sodium bicarbonate, water, and dried overmagnesium sulfate. Evaporation of the solvent gave an oil whichcrystallized on cooling to yield a yellow solid which was trituratedwith n-butylchloride to afford 8.0 g of the title compound as a whitecrystalline material; m.p. 116°-120° C.

NMR (CDCl₃); ppm 8.1 (s, 1H, ArH); 4.5 (t, 2H, OCH₂); 2.9 (t, 2H, CH₂).

EXAMPLE 101-Chloro-6,7-dihydro-4H-thieno[3,4-C]pyran-4-one-3-sulfonamide

To a solution of 10 ml of chloroform, containing 0.75 ml ofchlorosulfonic acid, was added 1.0 g of the lactone described in theprevious example. A slight exotherm was noted. The reaction solution wasrefluxed for 3 hours and cooled. To this mixture was added 0.8 ml ofthionyl choride and reflux was continued an additional 2 hours. Thereaction was cooled, poured onto ice, and extracted with methylenechloride. The organic layer was washed with saturated sodium bicarbonateand dried over magnesium sulfate. Evaporation of the solvent afforded ayellow oil which slowly crystallized. The crude sulfonyl chloride wasdissolved in 50 ml of tetrahydrofuran and treated with 0.5 ml ofconcentrated ammonium hydroxide. A slight exotherm was noted along withconcomitant formation of a white solid. The reaction mixture was stirredovernight and the tetrahyorofuran evaporated. The residue was taken upin methylene chloride and water. The organic layer was dried overmagnesium sulfate. Evaporation of the methylene chloride gave a tanresidue, which after trituration with n-butylchloride, afforded 300 mgof the title compound, after filtration and drying, as a white solid;m.p. 205°-208° C.

EXAMPLE 111-Chloro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-6,7-dihydro-4-oxo-4H-thieno[3,4-c]pyran-3-sulfonamide

To a cloudy solution of 0.27 g of the product of the previous exampleand 0.28 g of phenyl(4,6-dimethoxypyrimidin-2-yl)carbamate in 10 ml ofp-dioxane was added 0.15 ml of 1,5-diazabicyclo[5.4.0]undec-5-ene (DBU).The reaction was stirred for 1 hour, diluted with 30 ml of water, andfiltered. The filtrate was acidified with 5 drops of concentratedhydrochloric acid to afford a white precipitate which was filtered offand washed with a small portion of water. The precipitate was suctiondried and further dried in vacuo at 60° C., to afford 200 mg of thetitle compound as a white solid; m.p. 110°-114° C.

NMR (CDCl₃) ppm 13.24 (bs, 1H, SO₂ NH); 7.4 (bs, 1H, CONH); 5.79 (s, 1H,pyH); 4.53 (t, 2H, OCH₂); 4.02 (s, 6H, 2-OCH₃); 2.96 (s, 2H, CH₂).

IR (Nujol) 1720, 1705 cm⁻¹ (C=O's).

Following the procedures describes in Equations 1-21 and Examples 1-11,one skilled in the art can readily prepare the following compounds.##STR37##

                                      TABLE Ia                                    __________________________________________________________________________    Structure Ia                                                                  n  Q    G   R   R.sub.1                                                                            R.sub.2 R.sub.3                                                                             X       Y         Z   m.p.                 __________________________________________________________________________                                                             (°C.)         1  SO.sub.2                                                                           S   H   H    H       H     CH.sub.3                                                                              CH.sub.3  CH  214-220°      1  SO.sub.2                                                                           S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 CH  224-226°      1  SO.sub.2                                                                           S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH  228-230°      1  SO.sub.2                                                                           S   H   H    H       H     Cl      OCH.sub.3 CH  214-220°      1  SO.sub.2                                                                           S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N   195-197°      1  SO.sub.2                                                                           S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 N   190-194°      0  SO.sub.2                                                                           S   H   H    H       H     CH.sub.3                                                                              CH.sub.3  CH                       0  SO.sub.2                                                                           S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    H       H     Cl      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    H       H     Br      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              CH.sub.3  CH  218-219              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH  208-209              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH  186-187              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     Cl      OCH.sub.3 CH  203-204              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     Br      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N   192-193              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 N   176-178              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3  CH  189-191              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 CH  208-210              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 CH  237-238              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            Cl      OCH.sub.3 CH  231-232              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            Br      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 N   136-140              0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 N   202-203              1  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              CH.sub.3  CH                       1  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       1  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       1  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     Cl      OCH.sub.3 CH                       1  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     Br      OCH.sub.3 CH                       1  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        1  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 N                        1  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 CH                       1  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 CH                       1  S    S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        1  S    S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       1  S    S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        1  S    S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       1  S    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 N                        1  S    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 CH                       0  S    S   H   H    H       H     CH.sub.3                                                                              CH.sub.3  CH                       0  S    S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  S    S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  S    S   H   H    H       H     Cl      OCH.sub.3 CH                       0  S    S   H   H    H       H     Br      OCH.sub.3 CH                       0  S    S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  S    S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 N                        0  S    S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              CH.sub.3  CH  197-198              0  S    S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH  199-200              0  S    S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH  190-191              0  S    S   H   H    CH.sub.3                                                                              H     Cl      OCH.sub.3 CH  185-186              0  S    S   H   H    CH.sub.3                                                                              H     Br      OCH.sub.3 CH                       0  S    S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N   182-183              0  S    S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 N   179-181              0  S    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3  CH  190-191              0  S    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 CH  163-164              0  S    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 CH  180-181              0  S    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            Cl      OCH.sub.3 CH  166-167              0  S    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            Br      OCH.sub.3 CH                       0  S    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 N   187-188              0  S    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 N   173-174              0  SO   S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              CH.sub.3  CH                       0  SO   S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO   S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO   S   H   H    CH.sub.3                                                                              H     Cl      OCH.sub.3 CH                       0  SO   S   H   H    CH.sub.3                                                                              H     Br      OCH.sub.3 CH                       0  SO   S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO   S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 N                        0  O    S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  O    S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  O    S   H   H    CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  O    S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  O    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 N                        0  O    S   H   H    CH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 CH                       1  O    S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 N                        1  O    S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  CH.sub.2                                                                           S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  CH.sub.2                                                                           S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       1  CH.sub.2                                                                           S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        1  CH.sub.2                                                                           S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  CH.sub.2                                                                           O   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  CH.sub.2                                                                           O   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       1  CH.sub.2                                                                           O   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        1  CH.sub.2                                                                           O   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  CH.sub.2                                                                           NH  H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  CH.sub.2                                                                           NH  H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       1  CH.sub.2                                                                           NH  H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        1  CH.sub.2                                                                           NH  H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  CH.sub.2                                                                           NCH.sub.3                                                                         H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  CH.sub.2                                                                           NCH.sub.3                                                                         H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       1  CH.sub.2                                                                           NCH.sub.3                                                                         H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        1  CH.sub.2                                                                           NCH.sub.3                                                                         H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  CHCH.sub.3                                                                         S   H   H    H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  CHCH.sub.3                                                                         S   H   H    H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           O   H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              CH.sub.3  CH                       0  SO.sub.2                                                                           O   H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           O   H   CH.sub.3                                                                           H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           O   H   CH.sub.3                                                                           H       H     Cl      OCH.sub.3 CH                       0  SO.sub.2                                                                           O   H   CH.sub.3                                                                           H       H     Br      OCH.sub.3 CH                       0  SO.sub.2                                                                           O   H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           O   H   CH.sub.3                                                                           H       H     OCH.sub.3                                                                             OCH.sub.3 N                        0  SO.sub.2                                                                           NH  H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              CH.sub.3  CH                       0  SO.sub.2                                                                           NH  H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           NH  H   CH.sub.3                                                                           H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           NH  H   CH.sub.3                                                                           H       H     Cl      OCH.sub.3 CH                       0  SO.sub.2                                                                           NH  H   CH.sub.3                                                                           H       H     Br      OCH.sub.3 CH                       0  SO.sub.2                                                                           NH  H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           NH  H   CH.sub.3                                                                           H       H     OCH.sub.3                                                                             OCH.sub.3 N                        0  SO.sub.2                                                                           NCH.sub.3                                                                         H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              CH.sub.3  CH                       0  SO.sub.2                                                                           NCH.sub.3                                                                         H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           NCH.sub.3                                                                         H   CH.sub.3                                                                           H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           NCH.sub.3                                                                         H   CH.sub.3                                                                           H       H     Cl      OCH.sub.3 CH                       0  SO.sub.2                                                                           NCH.sub.3                                                                         H   CH.sub.3                                                                           H       H     Br      OCH.sub.3 CH                       0  SO.sub.2                                                                           NCH.sub.3                                                                         H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           NCH.sub.3                                                                         H   CH.sub.3                                                                           H       H     OCH.sub.3                                                                             OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              CH.sub.3  CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           H       H     Cl      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           H       H     Br      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           H       H     OCH.sub.3                                                                             OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     CH.sub.3                                                                              CH.sub.3  CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     Cl      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              CH.sub.3  CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                            Cl      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                            Br      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   Cl   H       H     CH.sub.3                                                                              CH.sub.3  CH                       0  SO.sub.2                                                                           S   H   Cl   H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   Cl   H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   Cl   H       H     Cl      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   Cl   H       H     Br      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   Cl   H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   Cl   H       H     OCH.sub.3                                                                             OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   Cl   CH.sub.3                                                                              H     CH.sub.3                                                                              CH.sub.3  CH                       0  SO.sub.2                                                                           S   H   Cl   CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH  214-215              0  SO.sub.2                                                                           S   H   Cl   CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH  209-210              0  SO.sub.2                                                                           S   H   Cl   CH.sub.3                                                                              H     Cl      OCH.sub.3 CH  190-194              0  SO.sub.2                                                                           S   H   Cl   CH.sub.3                                                                              H     Br      OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   Cl   CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   Cl   CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   Cl   CH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   Br   H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   Br   H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   Br   H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   Br   CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   Br   CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   Br   CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   OCH.sub.3                                                                          H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   OCH.sub.3                                                                          H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   OCH.sub.3                                                                          H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   OCH.sub.3                                                                          CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   OCH.sub.3                                                                          CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   OCH.sub.3                                                                          CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   SCH.sub.3                                                                          H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   SCH.sub.3                                                                          H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   SCH.sub.3                                                                          H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   SCH.sub.3                                                                          CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   SCH.sub.3                                                                          CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   SCH.sub.3                                                                          CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   SO.sub.2 CH.sub.3                                                                  H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   SO.sub.2 CH.sub.3                                                                  H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   SO.sub.2 CH.sub.3                                                                  H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   SO.sub.2 CH.sub.3                                                                  CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   SO.sub.2 CH.sub.3                                                                  CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   SO.sub.2 CH.sub.3                                                                  CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   NO.sub.2                                                                           H       H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   NO.sub.2                                                                           H       H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   NO.sub.2                                                                           H       H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   NO.sub.2                                                                           CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   NO.sub.2                                                                           CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   NO.sub.2                                                                           CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  S    S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  S    S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  S    S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  S    S   H   OCH.sub.3                                                                          CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  S    S   H   OCH.sub.3                                                                          CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  S    S   H   OCH.sub.3                                                                          CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  S    S   H   Cl   CH.sub.3                                                                              H     CH.sub.3                                                                              CH.sub.3  CH  200-202              0  S    S   H   Cl   CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH  180-182              0  S    S   H   Cl   CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH  197-199              0  S    S   H   Cl   CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N   157-159              0  S    S   H   Cl   CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 N   163-164              0  S    S   H   Cl   CH.sub.3                                                                              H     Cl      OCH.sub.3 CH  168-170              0  S    S   H   SCH.sub.3                                                                          CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  S    S   H   SCH.sub.3                                                                          CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  S    S   H   SCH.sub.3                                                                          CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  S    S   H   SO.sub.2 CH.sub.3                                                                  CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  S    S   H   SO.sub.2 CH.sub.3                                                                  CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  S    S   H   SO.sub.2 CH.sub.3                                                                  CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  S    S   H   NO.sub.2                                                                           CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 N                        0  S    S   H   NO.sub.2                                                                           CH.sub.3                                                                              H     CH.sub.3                                                                              OCH.sub.3 CH                       0  S    S   H   NO.sub.2                                                                           CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.2 CH.sub.3                                                                     H     CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   H    CH.sub.2 CH.sub.3                                                                     H     CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.2 CH.sub.3                                                                     H     OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.2 CH.sub.2 CH.sub.3                                                            H     OCH     OCH.sub.3 CH.sub. 3                0  SO.sub.2                                                                           S   H   H    H       CH(CH.sub.3).sub.2                                                                  OCH     OCH.sub.3 CH.sub.3                 0  SO.sub.2                                                                           S   H   H    H       C(CH.sub.3).sub.3                                                                   OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   CH.sub.3                                                                          H    H       CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   CH.sub.3                                                                          H    H       CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   CH.sub.3                                                                          H    H       CH.sub.3                                                                            CH.sub.3                                                                              OCH.sub.3 N                        0  SO.sub.2                                                                           S   CH.sub.3                                                                          H    H       CH.sub.3                                                                            OCH.sub.3                                                                             OCH.sub.3 N                        0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.2 CH.sub.3                                                                    OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.2 CH.sub.2 CH.sub.3                                                           OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH(CH.sub.3).sub.2                                                                   OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     F       OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     CH.sub.2 F                                                                            OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCHF.sub.2                                                                            OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.2 CF.sub.3                                                                    OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     CF.sub.3                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             H         CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                      CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH.sub.2 CH.sub.3                                                                       CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH.sub.2 CH.sub.2 CH.sub.3                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             cyclopropyl                                                                             N                        0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CCH       CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CCCH.sub.3                                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH.sub.2 CCCH.sub.3                                                                     CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                      CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             NH.sub. 2 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                              N                        0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             N(CH.sub.3).sub.2                                                                       CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CF.sub.3  CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             SCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.2 CHCH.sub.2                                                                    CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.2 CCH                                                                           CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH        CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             N.sub.3   CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                            CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                      CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                     CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH(SCH.sub.3).sub.2                                                                     CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             C(CH.sub.3)(OCH.sub.3).sub.2                                                            CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                                       CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                              ##STR38##                                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                              ##STR39##                                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH(OCH.sub.2 CH.sub.3).sub.2                                                            CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCF.sub.2 H                                                                             CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             SCF.sub.2 H                                                                             CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCF.sub.2 CHClF                                                                         CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCF.sub.2 CHBrF                                                                         CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCF.sub.2 CHFCF.sub.3                                                                   CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CCH.sub.3                0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CC.sub.2 H.sub.5         0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CCl                      0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.3 CBr                      0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             (CH.sub.2).sub.3 CH.sub.3                                                               CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             O(CH.sub.2).sub.3 CH.sub.3                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             O(CH.sub.2).sub.3 CF.sub.3                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             (CH.sub.2).sub.3 CF.sub.3                                                               CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             S(CH.sub.2).sub.3 CF.sub.3                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             S(CH.sub.2).sub.2 CH.sub.3                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             I         CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH.sub.2 O(CH.sub.2).sub.3                                                    CH.sub.3  CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             NH(CH.sub.2).sub.3 CH.sub.3                                                             CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             N(CH.sub.2 CH.sub.2 CH.sub.3).s                                               ub.2      CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.2 CHCHCH.sub.3                                                                  CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             OCH.sub.2 CCCH.sub.3                                                                    CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH.sub.2 S(CH.sub.2).sub.3                                                    CH.sub.3  CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             (CH.sub.2).sub.4 Cl                                                                     CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             cyclopentyl                                                                             CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CHO       CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             C(O)CH.sub.3                                                                            CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             CH(SCH.sub.3).sub.2                                                                     CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                              ##STR40##                                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                              ##STR41##                                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                              ##STR42##                                                                              CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     OCH.sub.3                                                                             N(OCH.sub.3)CH.sub.3                                                                    CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     CH.sub.2 CH.sub.3                                                                     OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     (CH.sub.2).sub.3 CH.sub.3                                                             OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     O(CH.sub.2).sub.3 CH.sub.3                                                            OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     O(CH.sub.2).sub.3 CCl.sub.3                                                           OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     (CH.sub.2).sub.4 F                                                                    OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     S(CH.sub.2).sub.4 Br                                                                  OCH.sub.3 CH                       0  SO.sub. 2                                                                          S   H   H    CH.sub.3                                                                              H     SC(CH.sub.3).sub.3                                                                    OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     (CH.sub.2).sub.4 OCH.sub.3                                                            OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     O(CH.sub.2).sub.4 OCH.sub.3                                                           OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     NH.sub.2                                                                              OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     NHCH(CH.sub.3).sub.2                                                                  OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    CH.sub.3                                                                              H     N[CH(CH.sub.3).sub.2 ].sub.2                                                          OCH.sub.3 CH                       0  SO.sub.2                                                                           S   H   H    H       H     OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                              N                        0  SO.sub.2                                                                           S   H   CH.sub.3                                                                           CH.sub.3                                                                              H     OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                              N                        0  SO.sub.2                                                                           S   H   Cl   CH.sub.3                                                                              H     OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                              N                        __________________________________________________________________________

                  TABLE Ib                                                        ______________________________________                                        Structure Ib                                                                                                                      m.p.                      n   G     Q      R   R.sub.1 '                                                                          R.sub.2                                                                            R.sub.3                                                                            X     Y     Z   (°C.)              ______________________________________                                        0   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            CH.sub.3                                                                            CH                            0   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           H    Cl    OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           H    Br    OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                             0   S     S      H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            CH.sub.3                                                                            CH                            0   S     S      H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   S     S      H   H    CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   S     S      H   H    CH.sub.3                                                                           H    Cl    OCH.sub.3                                                                           CH                            0   S     S      H   H    CH.sub.3                                                                           H    Br    OCH.sub.3                                                                           CH                            0   S     S      H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   S     S      H   H    CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                             0   S     SO.sub.2                                                                             H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   S     SO.sub.2                                                                             H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   H    H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   S     S      H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   S     S      H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   S     S      H   H    H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   S     S      H   H    CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   S     S      H   H    CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   S     S      H   H    CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub. 3                                                                          OCH.sub.3                                                                           CH                            1   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             1   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            1   S     SO.sub.2                                                                             H   H    CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   S     O      H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   S     O      H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   S     O      H   H    CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   S     CH.sub.2                                                                             H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   S     CH.sub.2                                                                             H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   S     CH.sub.2                                                                             H   H    H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            1   S     CH.sub.2                                                                             H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             1   S     CH.sub.2                                                                             H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            1   S     CH.sub.2                                                                             H   H    H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   Cl   CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   S     SO.sub.2                                                                             H   Cl   CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   Cl   CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   CH.sub.3                                                                           CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   S     SO.sub.2                                                                             H   CH.sub.3                                                                           CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   S     SO.sub.2                                                                             H   CH.sub.3                                                                           CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            ______________________________________                                    

                                      TABLE Ic                                    __________________________________________________________________________    Structure Ic                                                                                                    m.p.                                        n W.sub.2                                                                          G   R R.sub.1                                                                          R.sub.2                                                                          R.sub.3                                                                          X     Y    Z  (°C.)                                __________________________________________________________________________    1 O  S   H CH.sub.3                                                                         H  H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                             1 O  S   H CH.sub.3                                                                         H  H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                             1 O  S   H CH.sub.3                                                                         H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          H                                              1 O  S   H CH.sub.3                                                                         H  H  Cl    OCH.sub.3                                                                          CH                                             1 O  S   H CH.sub.3                                                                         H  H  Br    OCH.sub.3                                                                          CH                                             1 O  S   H CH.sub.3                                                                         H  H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                              1 O  S   H CH.sub.3                                                                         H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          N                                              1 O  O   H CH.sub.3                                                                         H  H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                             1 O  O   H CH.sub.3                                                                         H  H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                             1 O  O   H CH.sub.3                                                                         H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             1 O  O   H CH.sub.3                                                                         H  H  Cl    OCH.sub.3                                                                          CH                                             1 O  O   H CH.sub.3                                                                         H  H  Br    OCH.sub.3                                                                          CH                                             1 O  O   H CH.sub.3                                                                         H  H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                              1 O  O   H CH.sub.3                                                                         H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          N                                              1 O  NH  H CH.sub.3                                                                         H  H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                             1 O  NH  H CH.sub.3                                                                         H  H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                             1 O  NH  H CH.sub.3                                                                         H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             1 O  NH  H CH.sub.3                                                                         H  H  Cl    OCH.sub.3                                                                          CH                                             1 O  NH  H CH.sub.3                                                                         H  H  Br    OCH.sub.3                                                                          CH                                             1 O  NH  H CH.sub.3                                                                         H  H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                              1 O  NH  H CH.sub.3                                                                         H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          N                                              1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H  H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                             1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H  H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                             1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H  H  Cl    OCH.sub.3                                                                          CH                                             1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H  H  Br    OCH.sub.3                                                                          CH                                             1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H  H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                              1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H  H  OCH.sub. 3                                                                          OCH.sub.3                                                                          N                                              0 O  S   H CH.sub.3                                                                         H  H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                             0 O  S   H CH.sub.3                                                                         H  H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                             0 O  S   H CH.sub.3                                                                         H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             0 O  S   H CH.sub.3                                                                         H  H  Cl    OCH.sub.3                                                                          CH                                             0 O  S   H CH.sub.3                                                                         H  H  Br    OCH.sub.3                                                                          CH                                             0 O  S   H CH.sub.3                                                                         H  H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                              0 O  S   H CH.sub.3                                                                         H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          N                                              1 O  S   H H  H  H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                             1 O  S   H H  H  H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                             1 O  S   H H  H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             1 O  S   H H  H  H  Cl    OCH.sub.3                                                                          CH                                             1 O  S   H H  H  H  Br    OCH.sub.3                                                                          CH                                             1 O  S   H H  H  H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                              1 O  S   H H  H  H  OCH   OCH.sub.3                                                                          N.sub.3                                        1 O  S   H Cl H  H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                             1 O  S   H Cl H  H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                             1 O  S   H Cl H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             1 O  S   H Cl H  H  Cl    OCH.sub.3                                                                          CH                                             1 O  S   H Cl H  H  Br    OCH.sub.3                                                                          CH                                             1 O  S   H Cl H  H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                              1 O  S   H Cl H  H  OCH.sub.3                                                                           OCH.sub.3                                                                          N                                              1 O  S   H CH.sub.3                                                                         CH.sub.3                                                                         H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             1 O  S   H CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             1 O  S   H CH.sub.3                                                                         Cl Cl OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             1 S  S   H CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                             1 O  S   H CH.sub.3                                                                         H  H  OCH.sub.2 CH.sub.3                                                                  NHCH.sub.3                                                                         N                                              __________________________________________________________________________

                  TABLE Id                                                        ______________________________________                                        Structure Id                                                                                                                      m.p.                      n   W.sub.2                                                                              G     R   R.sub.1 '                                                                          R.sub.2                                                                            R.sub.3                                                                            X     Y     Z   (°C.)              ______________________________________                                        1   O      S     H   H    H    H    CH.sub.3                                                                            CH.sub.3                                                                            CH                            1   O      S     H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            1   O      S     H   H    H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            1   O      S     H   H    H    H    Cl    OCH.sub.3                                                                           CH                            1   O      S     H   H    H    H    Br    OCH.sub.3                                                                           CH                            1   O      S     H   H    H    H    CH.sub.3                                                                            OCH3  N                             1   O      S     H   H    H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                             1   O      S     H   H    CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            1   O      S     H   H    CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            1   O      S     H   H    Cl   Cl   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            1   O      S     H   CH.sub.3                                                                           H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            1   O      S     H   Cl   H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   O      S     H   H    H    H    CH.sub.3                                                                            CH.sub.3                                                                            CH                            0   O      S     H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   O      S     H   H    H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   O      S     H   H    H    H    Cl    OCH.sub.3                                                                           CH                            0   O      S     H   H    H    H    Br    OCH.sub.3                                                                           CH                            0   O      S     H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   O      S     H   H    H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                             ______________________________________                                    

                                      TABLE Ie                                    __________________________________________________________________________    Structure Ie                                                                                                       m.p.                                     n W.sub.2                                                                          G   R R.sub.1                                                                          R.sub.4                                                                             R.sub.5                                                                          X     Y    Z  (°C.)                             __________________________________________________________________________    1 O  S   H CH.sub.3                                                                         H     H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                          1 O  S   H CH.sub.3                                                                         H     H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                          1 O  S   H CH.sub.3                                                                         H     H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          1 O  S   H CH.sub.3                                                                         H     H  Cl    OCH.sub.3                                                                          CH                                          1 O  S   H CH.sub.3                                                                         H     H  Br    OCH.sub.3                                                                          CH                                          1 O  S   H CH.sub.3                                                                         H     H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                           1 O  S   H CH.sub.3                                                                         H     H  OCH.sub.3                                                                           OCH.sub.3                                                                          N                                           1 O  O   H CH.sub.3                                                                         H     H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                          1 O  O   H CH.sub.3                                                                         H     H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                          1 O  O   H CH.sub.3                                                                         H     H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          1 O  O   H CH.sub.3                                                                         H     H  Cl    OCH.sub.3                                                                          CH                                          1 O  O   H CH.sub.3                                                                         H     H  Br    OCH.sub.3                                                                          CH                                          1 O  O   H CH.sub.3                                                                         H     H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                           1 O  O   H CH.sub.3                                                                         H     H  OCH.sub.3                                                                           OCH.sub.3                                                                          N                                           1 O  NH  H CH.sub.3                                                                         H     H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                          1 O  NH  H CH.sub.3                                                                         H     H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                          1 O  NH  H CH.sub.3                                                                         H     H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          1 O  NH  H CH.sub.3                                                                         H     H  Cl    OCH.sub.3                                                                          CH                                          1 O  NH  H CH.sub.3                                                                         H     H  Br    OCH.sub.3                                                                          CH                                          1 O  NH  H CH.sub.3                                                                         H     H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                           1 O  NH  H CH.sub.3                                                                         H     H  OCH.sub.3                                                                           OCH.sub.3                                                                          N                                           1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H     H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                          1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H     H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                          1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H     H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H     H  Cl    OCH.sub.3                                                                          CH                                          1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H     H  Br    OCH.sub.3                                                                          CH                                          1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H     H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                           1 O  NCH.sub.3                                                                         H CH.sub.3                                                                         H     H  OCH.sub.3                                                                           OCH.sub.3                                                                          N                                           1 O  S   H H  H     H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          1 O  S   H Cl H     H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          1 O  S   H H  CH.sub.3                                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          1 O  S   H H  CH    CH.sub.3                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          1 O  S   H H  CH.sub.2 CH.sub.3                                                                   H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          1 O  S   H H  (CH.sub.2).sub.3 CH.sub.3                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          0 O  S   H H  CH.sub.3                                                                            H  CH.sub.3                                                                            CH.sub.3                                                                           CH                                          0 O  S   H H  CH.sub.3                                                                            H  CH.sub.3                                                                            OCH.sub.3                                                                          CH                                          0 O  S   H H  CH.sub.3                                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                          0 O  S   H H  CH.sub.3                                                                            H  Cl    OCH.sub.3                                                                          CH                                          0 O  S   H H  CH.sub.3                                                                            H  Br    OCH.sub.3                                                                          CH                                          0 O  S   H H  CH.sub.3                                                                            H  CH.sub.3                                                                            OCH.sub.3                                                                          N                                           0 O  S   H H  CH.sub.3                                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                          N                                           0 S  S   H H  H     H  OCH.sub.3                                                                           OCH.sub. 3                                                                         CH                                          0 O  S   H H  H     H  OCH.sub.2 CH.sub.3                                                                  NHCH.sub.3                                                                         N                                           1 O  S   H H  H     H  OCH.sub.2 CH.sub.3                                                                  NHCH.sub.3                                                                         N                                           __________________________________________________________________________

                  TABLE If                                                        ______________________________________                                        Structure If                                                                                                                      m.p.                      W.sub.2                                                                             n     G     R   R.sub.1 '                                                                          R.sub.4                                                                           R.sub.5                                                                           X     Y     Z    (°C.)              ______________________________________                                        O     1     S     H   H    H   H   CH.sub.3                                                                            CH.sub.3                                                                            CH                             O     1     S     H   H    H   H   CH.sub.3                                                                            OCH.sub.3                                                                           CH                             O     1     S     H   H    H   H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                             O     1     S     H   H    H   H   Cl    OCH.sub.3                                                                           CH                             O     1     S     H   H    H   H   Br    OCH.sub.3                                                                           CH                             O     1     S     H   H    H   H   CH.sub.3                                                                            OCH.sub.3                                                                           N                              O     1     S     H   H    H   H   OCH.sub.3                                                                           OCH.sub.3                                                                           N                              O     0     S     H   H    H   H   CH.sub.3                                                                            CH.sub.3                                                                            CH                             O     0     S     H   H    H   H   CH.sub.3                                                                            OCH.sub.3                                                                           CH                             O     0     S     H   H    H   H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                             O     0     S     H   H    H   H   Cl    OCH.sub.3                                                                           CH                             O     0     S     H   H    H   H   Br    OCH.sub.3                                                                           CH                             O     0     S     H   H    H   H   CH.sub.3                                                                            OCH.sub.3                                                                           N                              O     0     S     H   H    H   H   OCH.sub.3                                                                           OCH.sub.3                                                                           N                              O     1     S     H   CH.sub.3                                                                           H   H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                             O     0     S     H   CH.sub.3                                                                           H   H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                             O     0     S     H   Cl   H   H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                             O     1     S     H   Cl   H   H   CH.sub.3                                                                            CH.sub.3                                                                            CH                             O     1     S     H   Cl   H   H   CH.sub.3                                                                            OCH.sub.3                                                                           CH                             O     1     S     H   Cl   H   H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                             O     1     S     H   Cl   H   H   Cl    OCH.sub.3                                                                           CH                             O     1     S     H   Cl   H   H   Br    OCH.sub.3                                                                           CH                             O     1     S     H   Cl   H   H   CH.sub.3                                                                            OCH.sub.3                                                                           N                              O     1     S     H   Cl   H   H   OCH.sub.3                                                                           OCH.sub.3                                                                           N                              ______________________________________                                    

                                      TABLE Ig                                    __________________________________________________________________________    Structure Ig                                                                  n G   R  R.sub.1                                                                          R.sub.5                                                                          R.sub.6        X     Y      Z  m.p. (°C.)               __________________________________________________________________________    0 S   H  H  H  H              CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  H  H  H              CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  H              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  H              Cl    OCH.sub.3                                                                            CH                                 0 S   H  H  H  H              Br    OCH.sub.3                                                                            CH                                 0 S   H  H  H  H              CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  H              OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.3       CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  H  H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.3       Cl    OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.3       Br    OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                                                             N                                  0 S   H  H  H  CH.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(CH.sub.3).sub.2                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH(CH.sub.3).sub.2                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(CH.sub.3).sub.2                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          Cl    OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          Br    OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH(CH.sub.3).sub.2                                                                  CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH(CH.sub.3).sub.2                                                                  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH(CH.sub.3).sub.2                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(CH.sub.3)CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH(CH.sub.3)CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(CH.sub.3)CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(CH.sub.3).sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(CH.sub.3).sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(CH.sub.3).sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  (CH.sub.2).sub. 5 CH.sub.3                                                                   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  (CH.sub.2).sub.5 CH.sub.3                                                                    CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  (CH.sub.2).sub.5 CH.sub.3                                                                    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CHCH.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CHCH.sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CHCH.sub.2                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CHCH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CHCH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CHCH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 C(CH.sub.3)C(CH.sub.3).sub.2                                                        CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 C(CH.sub.3)C(CH.sub.3).sub.2                                                        CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 C(CH.sub.3)C(CH.sub.3).sub.2                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H                                                                                 ##STR43##     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CCH   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CCH   CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CCH   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CCCH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CCCH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CCCH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  (CH.sub.2).sub.4 CCH                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  cyclopropyl    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  cyclopentyl    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  cyclohexyl     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2cyclopropyl                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2cyclopentyl                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  phenyl         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   -p-nitrophenyl                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  phenylthio     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  SO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  OCH.sub.3      OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)CH.sub.3   OCH.sub.2 CH.sub.3                                                                  NHCH.sub.3                                                                           N                                  0 S   H  H  H  C(O)CH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)(CH.sub.2).sub.5 CH.sub.3                                                                OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CO.sub.2 CH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                  NHCH.sub.3                                                                           N                                  0 S   H  H  H  CO.sub.2 CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CO.sub.2 CH.sub.2 CHCH.sub.2                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  N(CH.sub.3).sub.2                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CN             OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  Si(CH.sub.3).sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  Si(CH.sub.3).sub.2 C(CH.sub.3).sub.3                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  Si(CH.sub.3).sub.2 Ph                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  Si(CH.sub.3).sub.2 CH.sub.2 Ph                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 OCH.sub.2 CH.sub.3                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.2 CH.sub.3                                                                  NHCH.sub.3                                                                           N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.2 CH.sub.3                                                                  NHCH.sub.3                                                                           N                                  0 S   H  H  H  CF.sub.2 H     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 Br                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CF.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 O S   H  H  H  CH.sub.2 C(Cl)CH.sub.2                                                                       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 OH                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.2 CH.sub.3                                                                  NHCH.sub.3                                                                           N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 OCO.sub.2 (CH.sub.2).sub.5 CH.sub.3                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 OC(O)NHCH.sub.3                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 OSO.sub.2 Ph                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 Si(CH.sub.3).sub.3                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 SCH.sub.3                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 SOCH.sub.3                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 SCN   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CN    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub. 2 CH.sub.2 CN                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NO.sub.2                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 C(O)CH.sub.3                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CO.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CO.sub.2 C(CH.sub.3).sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 C(O)N(CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  benzyl         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   -p-chlorobenzyl                                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   .sub.--m-fluorobenzyl                                                                       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   -o-bromobenzyl                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   -p-methylbenzyl                                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   -p-methoxybenzyl                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   -p-cyanobenzyl                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   -p-nitrobenzyl                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   -p-methylthiobenzyl                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   -p-methylsulfonylbenzyl                                                                     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H   .sub.--m-trifluromethylbenzyl                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CO.sub.2 phenyl                                                                     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CO.sub.2cyclopentyl                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CO.sub.2 CH.sub.2 CCH                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH(OCH.sub.3).sub.2                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH(CN)SO.sub.2 CH.sub.3                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  2-pyridylmethyl                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  3-pyridylmethyl                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  4-pyridylmethyl                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  2-thienomethyl OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  3-thienomethyl OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  2-furanylmethyl                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   CH.sub.3                                                                         H  H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.3       CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.3       Cl    OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.3       Br    OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.3       CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  Cl H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.3       Cl    OCH.sub. 3                                                                           CH                                 0 S   H  Cl H  CH.sub.3       Br    OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 1 S   H  H  H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            N                                  1 S   H  H  H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 1 S   H  H  H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 1 S   H  H  H  H              CH.sub.3                                                                            OCH.sub.3                                                                            N                                  1 S   H  H  H  H              CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 1 S   H  H  H  H              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 O   H  CH.sub.3                                                                         H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 O   H  CH.sub.3                                                                         H  CH.sub. 3      CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 O   H  CH.sub.3                                                                         H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 NH  H  CH.sub.3                                                                         H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 NH  H  CH.sub.3                                                                         H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 NH  H  CH.sub.3                                                                         H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 NCH.sub.3                                                                         H  CH.sub.3                                                                         H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 NCH.sub.3                                                                         H  CH.sub.3                                                                         H  CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 NCH.sub.3                                                                         H  CH.sub.3                                                                         H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 O   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 O   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 NH  H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 NH  H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 NCH.sub.3                                                                         H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 NCH.sub.3                                                                         H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 O   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 O   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 NH  H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 NH  H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 NCH.sub.3                                                                         H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 NCH.sub.3                                                                         H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H                                                                                 ##STR44##     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H                                                                                 ##STR45##     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  (CO).sub.2 CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  (CO).sub.2 CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  (CO).sub.2 CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  (CO).sub.2 CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)N(CH.sub.3).sub.2                                                                        CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)N(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)N(CH.sub.3).sub.2                                                                        CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)N(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)NH.sub.2   CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)NH.sub.2   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)NH.sub.2   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)NH.sub.2   OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(S)SCH.sub.3  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(S)SCH.sub.3  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(S)SCH.sub.3  CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(S)SCH.sub.3  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(S)SCH.sub.2 CHCH.sub.2                                                                     CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(S)SCH.sub.2 CHCH.sub.2                                                                     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(S)SCH.sub.2 CHCH.sub.2                                                                     CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(S)SCH.sub.2 CHCH.sub.2                                                                     OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-thiophene                                                                              CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-thiophene                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-thiophene                                                                              CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-thiophene                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-pyridine CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-pyridine OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-pyridine CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-pyridine OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-furan    CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-furan    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-furan    CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-furan    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-thiazole CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-thiazole OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-thiazole CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-thiazole OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-oxazole  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-oxazole  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-oxazole  CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-oxazole  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-cyclopentanone                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-cyclopentanone                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-cyclopentanone                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-cyclopentanone                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-butyrolactone                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-butyrolactone                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-butyrolactone                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-butyrolactone                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-(5-Cl)thiophene                                                                        CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-(5-Cl)thiophene                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  C(O)2-(5-Cl)thiophene                                                                        CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  C(O)2-(5-Cl)thiophene                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 OP(O)(CH.sub.3).sub.2                                                               CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 OP(O)(CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 OP(O)(CH.sub.3).sub.2                                                               CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 OP(O)(CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 OP(O)OCH.sub.3).sub.2                                                      CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 OP(O)OCH.sub.3).sub.2                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 OP(O)OCH.sub.3).sub.2                                                      CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 OP(O)OCH.sub.3).sub.2                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 SP(O)(CH.sub.3).sub.2                                                               CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 SP(O)(CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 SP(O)(CH.sub.3).sub.2                                                               CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 SP(O)(CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 SP(O)(SCH.sub.3).sub.2                                                              CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 SP(O)(SCH.sub.3).sub.2                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 SP(O)(SCH.sub.3).sub.2                                                              CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 SP(O)(SCH.sub.3).sub.2                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 SP(S)(CH.sub.2 CH.sub.3).sub.2                                                      CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 SP(S)(CH.sub.2 CH.sub.3).sub.2                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 SP(S)(CH.sub.2 CH.sub.3).sub.2                                                      CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 SP(S)(CH.sub.2 CH.sub.3).sub.2                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 P(O)(OCH.sub.3).sub.2                                                      CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 P(O)(OCH.sub.3).sub.2                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 P(O)(OCH.sub.3 ).sub.2                                                     CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 P(O)(OCH.sub.3).sub.2                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 P(O)(OCH.sub.2 CH.sub.3).sub.2                                                      CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 P(O)(OCH.sub.2 CH.sub.3).sub.2                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 P(O)(OCH.sub.2 CH.sub.3).sub.2                                                      CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 P(O)(OCH.sub.2 CH.sub.3).sub.2                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHC(O)Ph                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHC(O)Ph                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHC(O)Ph                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHC(O)Ph                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHC(O)CH.sub.2 Cl                                                                   CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHC(O)CH.sub.2 Cl                                                                   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHC(O)CH.sub.2 Cl                                                                   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub. 2 NHC(O)CH.sub.2 Cl                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHC(O)OCH.sub.3                                                                     CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHC(O)OCH.sub.3                                                                     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHC(O)OCH.sub.3                                                                     CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHC(O)OCH.sub.3                                                                     OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHC(O)NHCH.sub.3                                                                    CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHC(O)NHCH.sub.3                                                                    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHC(O)NHCH.sub.3                                                                    CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHC(O)NHCH.sub.3                                                                    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHSO.sub.2 CH.sub.3                                                                 CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHSO.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHSO.sub.2 CH.sub.3                                                                 CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHSO.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                        CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                        CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHP(O)(CH.sub.3).sub.2                                                              CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHP(O)(CH.sub.3).sub.2                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHP(O)(CH.sub.3).sub.2                                                              CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHP(O)(CH.sub.3).sub.2                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  OH             CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  OH             OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  OH             CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  OH             OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  NH.sub.2       CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  NH.sub.2       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  NH.sub.2       CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  NH.sub.2       OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  P(O)(CH.sub.3).sub.2                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  P(O)(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  P(O)(CH.sub.3).sub.2                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  P(O)(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  P(O)(OCH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  P(O)(OCH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  P(O)(OCH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  P(O)(OCH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  P(S)(SCH.sub.3).sub.2                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  P(S)(SCH.sub.3).sub.2                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  (CO).sub.2 OCH.sub.2 CH.sub.3                                                                CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  (CO).sub.2 OCH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  (CO).sub.2 OCH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHP(O)(OCH.sub.3).sub.2                                                             CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHP(O)(OCH.sub.3).sub.2                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHP(O)(OCH.sub.3).sub.2                                                             CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHP(O)(OCH.sub.3).sub.2                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHP(S)(CH.sub.3).sub.2                                                              CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHP(S)(CH.sub.3).sub.2                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHP(S)(CH.sub.3).sub.2                                                              CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHP(S)(CH.sub.3).sub.2                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHP(S)(SCH.sub.3).sub.2                                                             CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHP(S)(SCH.sub.3).sub.2                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 NHP(S)(SCH.sub.3).sub.2                                                             CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 NHP(S)(SCH.sub.3).sub.2                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.21-Naphthyl                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.21-Naphthyl                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.21-Naphthyl                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.21-Naphthyl                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.22-Naphthyl                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.22-Naphthyl                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.22-Naphthyl                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.22-Naphthyl                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH(SCH.sub.3).sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(SCH.sub.3).sub.2                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(SCH.sub.3).sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH(SCH.sub.3).sub.2                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH(OCH.sub.3).sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(OCH.sub.3).sub.2                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(OCH.sub.3).sub.2                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH(OCH.sub.3).sub.2                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH(Cl)SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(Cl)SO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(Cl)SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH(Cl)SO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH(CN)OCH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(CN)OCH.sub.3                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH(CN)OCH.sub.3                                                                              CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH(CN)OCH.sub.3                                                                              OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH(Cl)CH.sub.2 Cl                                                                   CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH(Cl)CH.sub.2 Cl                                                                   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH(Cl)CH.sub.2 Cl                                                                   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH(Cl)CH.sub.2 Cl                                                                   OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 C(CH.sub.3)NOCH.sub.3                                                               CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 C(CH.sub.3)NOCH.sub.3                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 C(CH.sub.3)NOCH.sub.3                                                               CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 C(CH.sub.3)NOCH.sub.3                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 C(CH.sub.3)NOCH.sub.2 CH.sub.3                                                      CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 C(CH.sub.3)NOCH.sub.2 CH.sub.3                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 C(CH.sub.3)NOCH.sub.2 CH.sub.3                                                      CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 C(CH.sub.3)NOCH.sub.2 CH.sub.3                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHC(O)CH.sub.3                                                                             CH.sub.3                                                                            OCH.sub. 3                                                                           CH                                 0 S   H  H  H  CHCHC(O)CH.sub.3                                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCHC(O)CH.sub.3                                                                             CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHC(O)CH.sub.3                                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHC(O)OCH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCHC(O)OCH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCHC(O)OCH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHC(O)OCH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CHCHN(CH.sub.3).sub.2                                                               CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CHCHN(CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CHCHN(CH.sub.3).sub.2                                                               CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CHCHN(CH.sub.3).sub.2                                                               OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHC(O)NH.sub.2                                                                             CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCHC(O)NH.sub.2                                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCHC(O)NH.sub.2                                                                             CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHC(O)NH.sub.2                                                                             OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CHC(CH.sub.3)C(O)N(CH.sub.3).sub.2                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHC(CH.sub.3)C(O)N(CH.sub.3).sub.2                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHC(CH.sub.3)C(O)N(CH.sub.3).sub.2                                                           CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CHC(CH.sub.3)C(O)N(CH.sub.3).sub.2                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHP(O)(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHP(O)(OCH.sub.3).sub.2                                                                    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCHP(O)(OCH.sub.3).sub.2                                                                    CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHP(O)(OCH.sub.3).sub.2                                                                    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CHCH(NO.sub.2)                                                                      CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CHCH(NO.sub.2)                                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CHCH(NO.sub.2)                                                                      CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CHCH(NO.sub.2)                                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHCN         CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCHCN         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCHCN         CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCHCN         OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CCC(O)CH.sub.3                                                                      CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CCC(O)CH.sub.3                                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CCC(O)CH.sub.3                                                                      CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CCC(O)CH.sub.3                                                                      OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CCC(O)OCH.sub.3                                                                     CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CCC(O)OCH.sub.3                                                                     OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CCC(O)OCH.sub.3                                                                     CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CCC(O)OCH.sub.3                                                                     OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CCC(O)NHPh                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CCC(O)NHPh                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CCC(O)NHPh                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 C CC(O)NHPh                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCH2-Thienyl  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCH2-Thienyl  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCH2-Thienyl  CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCH2-Thienyl  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCH2-Pyridyl  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCH2-Pyridyl  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCH2-Pyridyl  CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCH2-Pyridyl  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCH2-Cyclopentanone                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCH2-Cyclopentanone                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CHCH2-Cyclopentanone                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CHCH2-Cyclopentanone                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CC2-thienyl    CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  C C2-thienyl   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CC2-thienyl    CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CC2-thienyl    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         H              CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         H              OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         H              CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         H              OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         CH.sub.3       CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         CH.sub.3       OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         CH.sub.2 CN    CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         CH.sub.2 CN    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         CH.sub.2 CN    CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         CH.sub.2 CN    OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   N  N  CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         C(O)CH.sub.3   CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         C(O)CH.sub.3   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         C(O)CH.sub.3   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         C(O)CH.sub.3   OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         C(O)OCH.sub.3  CH.sub.3                                                                            OCH.sub. 3                                                                           CH                                 0 S   H  H  CH.sub.3                                                                         C(O)OCH.sub.3  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  CH.sub.3                                                                         C(O)OCH.sub.3  CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  CH.sub.3                                                                         C(O)OCH.sub.3  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  H              H     OCH.sub.3                                                                            CH                                 0 S   H  H  H  H              NHCH.sub.3                                                                          OCH.sub.3                                                                            N                                  0 S   H  H  H  H              NHCH.sub.3                                                                          OCH.sub.2 CH.sub.3                                                                   N                                  0 S   H  H  H  H              OCH.sub.3                                                                           CCH    CH                                 0 S   H  H  H  H              OCH.sub.3                                                                           OCF.sub.2 H                                                                          CH                                 0 S   H  H  H  H              OCH.sub.3                                                                           cyclopropyl                                                                          CH                                 0 S   H  H  H  H              OCH.sub.3                                                                           OCH.sub.2 CF.sub.3                                                                   CH                                 0 S   H  H  H  CH.sub.3       H     OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.3       NHCH.sub.3                                                                          OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.3       NHCH.sub.3                                                                          OCH.sub.2 CH.sub.3                                                                   N                                  0 S   H  H  H  CH.sub.3       OCH.sub.3                                                                           CCH    CH                                 0 S   H  H  H  CH.sub.3       OCH.sub.3                                                                           OCF.sub.2 H                                                                          CH                                 0 S   H  H  H  CH.sub.3       OCH.sub.3                                                                           cyclopropyl                                                                          CH                                 0 S   H  H  H  CH.sub.3       OCH.sub.3                                                                           OCH.sub.2 CF.sub.3                                                                   CH                                 0 S   H  H  H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           H     OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           NHCH.sub.3                                                                          OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           NHCH.sub.3                                                                          OCH.sub.2 CH.sub.3                                                                   N                                  0 S   H  H  H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                           CCH    CH                                 0 S   H  H  H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                           OCF.sub.2 H                                                                          CH                                 0 S   H  H  H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                           cyclopropyl                                                                          CH                                 0 S   H  H  H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                           OCH.sub.2 CF.sub.3                                                                   CH                                 0 S   H  H  H  CH.sub.2 CH.sub.3                                                                            H     OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.3                                                                            NHCH.sub.3                                                                          OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.3                                                                            NHCH.sub.3                                                                          OCH.sub.2 CH.sub.3                                                                   N                                  0 S   H  H  H  CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           CCH    CH                                 0 S   H  H  H  CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCF.sub.2 H                                                                          CH                                 0 S   H  H  H  CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           cyclopropyl                                                                          CH                                 0 S   H  H  H  CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.2 CF.sub.3                                                                   CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 F                                                                          Cl    OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 F                                                                          Cl    OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 F                                                                          Cl    OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub. 2 Cl                                                                        Cl    OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 Cl                                                                         Cl    OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 Cl                                                                         Cl    OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 Cl    OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 Cl    OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 Cl    OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  H  H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 OCH.sub.3                                                                           Cl    OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 OCH.sub.3                                                                           Cl    OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  Cl H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 OCH.sub.3                                                                           Cl    OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 O S   H  H  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl    OCH.sub.3                                                                            CH                                 0 S   H  H  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl    OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl    OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  H S   H  H  H  C(O)CH.sub.3   CH.sub.3                                                                            CH.sub.3                                                                             CH                                 H S   H  H  H  C(O)CH.sub.3   CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H S   H  H  H  C(O)CH.sub.3   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 H S   H  H  H  C(O)CH.sub.3   Cl    OCH.sub.3                                                                            CH                                 H S   H  H  H  C(O)CH.sub.3   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  H S   H  H  H  C(O)CH.sub.3   OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  H S   H  CH.sub.3                                                                         H  C(O)CH.sub.3   CH.sub.3                                                                            CH.sub.3                                                                             CH                                 H S   H  CH.sub.3                                                                         H  C(O)CH.sub.3   CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H S   H  CH.sub.3                                                                         H  C(O)CH.sub.3   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 H S   H  CH.sub.3                                                                         H  C(O)CH.sub.3   Cl    OCH.sub.3                                                                            CH                                 H S   H  CH.sub.3                                                                         H  C(O)CH.sub.3   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  H S   H  CH.sub.3                                                                         H  C(O)CH.sub.3   OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  H S   H  Cl H  C(O)CH.sub.3   CH.sub.3                                                                            CH.sub.3                                                                             CH                                 H S   H  Cl H  C(O)CH.sub.3   CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H S   H  Cl H  C(O)CH.sub.3   OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 H S   H  Cl H  C(O)CH.sub.3   Cl    OCH.sub.3                                                                            CH                                 H S   H  Cl H  C(O)CH.sub.3   CH.sub.3                                                                            OCH.sub.3                                                                            N                                  H S   H  Cl H  C(O)CH.sub.3   OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  H S   H  H  H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                            CH.sub.3                                                                             CH                                 H S   H  H  H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H S   H  H  H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 H S   H  H  H  CH.sub.2 C(O)CH.sub.3                                                                        Cl    OCH.sub.3                                                                            CH                                 H S   H  H  H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                            OCH.sub.3                                                                            N                                  H S   H  H  H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  H S   H  CH.sub.3                                                                         H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                            CH.sub.3                                                                             CH                                 H S   H  CH.sub.3                                                                         H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 H S   H  CH.sub.3                                                                         H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 H S   H  CH.sub.3                                                                         H  CH.sub.2 C(O)CH.sub.3                                                                        Cl    OCH.sub.3                                                                            CH                                 H S   H  CH.sub.3                                                                         H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                            OCH.sub.3                                                                            N                                  H S   H  CH.sub.3                                                                         H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  Cl H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 C(O)CH.sub.3                                                                        Cl    OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  Cl H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  H  H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  H  H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  H  H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  H  H  CO.sub.2 CH.sub.3                                                                            Cl    OCH.sub.3                                                                            CH                                 0 S   H  H  H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  H  H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  CH.sub.3                                                                         H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CO.sub.2 CH.sub.3                                                                            Cl    OCH.sub.3                                                                            CH                                 0 S   H  CH.sub.3                                                                         H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  CH.sub.3                                                                         H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            N                                  0 S   H  Cl H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            CH.sub.3                                                                             CH                                 0 S   H  Cl H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CO.sub.2 CH.sub.3                                                                            Cl    OCH.sub.3                                                                            CH                                 0 S   H  Cl H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                            OCH.sub.3                                                                            N                                  0 S   H  Cl H  CO.sub.2 CH.sub.3                                                                            OCH.sub. 3                                                                          OCH.sub.3                                                                            N                                  __________________________________________________________________________

                                      TABLE Ih                                    __________________________________________________________________________    Structure Ih                                                                                                                  m.p.                          n  G  R  R.sub.1 '                                                                         R.sub.5                                                                          R.sub.6        X      Y     Z   (°C.)                  __________________________________________________________________________    0  S  H  H   H  H              CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  H              CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  H              OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  H              Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  H              Br     OCH.sub.3                                                                           CH                                0  S  H  H   H  H              CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  H              OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.3       CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  CH.sub.3       CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.3       OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.3       Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.3       Br     OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.3       CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.3       OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          Br     OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  Cl  H  H              CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  H              CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  H              OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  H              Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  H              Br     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  H              CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  H              OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.3       CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  CH.sub.3       CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.3       OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.3       Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.3       Br     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.3       CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.3       OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          Br     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 1  S  H  H   H  CH.sub.3       OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)CH.sub.3   OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                          N                                 0  S  H  H   H  CO.sub.2 CH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                   NHCH.sub.3                                                                          N                                 0  S  H  H   H  CO.sub.2 Ph    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH═CH.sub.2                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH═CHCH.sub.3                                                                   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C.tbd.CH                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C.tbd.CCH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  (CO).sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  (CO).sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  (CO).sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  (CO).sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)N(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)N(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)N(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)N(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)NH.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)NH.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)NH.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)NH.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(S)SCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(S)SCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(S)SCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(S)SCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(S)SCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(S)SCH.sub.2 CH═CH.sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(S)SCH.sub.2 CH═CH.sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(S)SCH.sub.2 CH═CH.sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-thiophene                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-thiophene                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-thiophene                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-thiophene                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-pyridine                                                                             CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-pyridine                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-pyridine                                                                             CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-pyridine                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-furan  CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-furan  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-furan  CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-furan  OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-thiazole                                                                             CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-thiazole                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-thiazole                                                                             CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-thiazole                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-oxazole                                                                              CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-oxazole                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-oxazole                                                                              CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-oxazole                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-cyclopentanone                                                                       CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-cyclopentanone                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-cyclopentanone                                                                       CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-cyclopentanone                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-butyrolactone                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-butyrolactone                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-butyrolactone                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-butyrolactone                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-(5-Cl)thiophene                                                                      CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-(5-Cl)thiophene                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)--2-(5-Cl)thiophene                                                                      CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)--2-(5-Cl)thiophene                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 OP(O)(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 OP(O)(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 OP(O)(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 OP(O)(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 OP(O)OCH.sub.3).sub.2                                                      CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 OP(O)OCH.sub.3).sub.2                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 OP(O)OCH.sub.3).sub.2                                                      CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 OP(O)OCH.sub.3).sub.2                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 SP(O)(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 SP(O)(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 SP(O)(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 SP(O)(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 SP(O)(SCH.sub.3).sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 SP(O)(SCH.sub.3).sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 SP(O)(SCH.sub.3).sub.2                                                              CH3    OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 SP(O)(SCH.sub.3).sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 SP(S)(CH.sub.2 CH.sub.3).sub.2                                                      CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 SP(S)(CH.sub.2 CH.sub.3).sub.2                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 SP(S)(CH.sub.2 CH.sub.3).sub.2                                                      CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 SP(S)(CH.sub.2 CH.sub.3).sub.2                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 P(O)(OCH.sub.2 CH.sub.3).sub.2                                                      CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 P(O)(OCH.sub.2 CH.sub.3).sub.2                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 P(O)(OCH.sub.2 CH.sub.3).sub.2                                                      CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 P(O)(OCH.sub.2 CH.sub.3).sub.2                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 P(O)(OCH.sub.3).sub.2                                                      CH.sub.3                                                                             OCH.sub. 3                                                                          CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 P(O)(OCH.sub.3).sub.2                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 P(O)(OCH.sub.3).sub.2                                                      CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 P(O)(OCH.sub.3).sub.2                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHC(O)Ph                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHC(O)Ph                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHC(O)Ph                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHC(O)Ph                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHC(O)CH.sub.2 Cl                                                                   CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHC(O)CH.sub.2 Cl                                                                   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHC(O)CH.sub.2 Cl                                                                   CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHC(O)CH.sub.2 Cl                                                                   OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHC(O)OCH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHC(O)OCH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHC(O)OCH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHC(O)OCH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHC(O)NHCH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHC(O)NHCH.sub.3                                                                    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHC(O)NHCH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHC(O)HCCH.sub.3                                                                    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHSO.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHSO.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHSO.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHSO.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHP(O)(CH.sub.3).sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHP(O)(CH.sub.3).sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHP(O)(CH.sub.3).sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHP(O)(CH.sub.3).sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  OH             CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  OH             OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  OH             CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  OH             OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  NH.sub.2       CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  NH.sub.2       OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  NH.sub.2       CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  NH.sub.2       OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  P(O)(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  P(O)(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  P(O)(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  P(O)(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  P(O)(SCH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  P(S)(SCH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  P(S)(SCH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  P(S)(SCH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  P(S)(SCH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  (CO).sub.2 OCH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  (CO).sub.2 OCH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  (CO).sub.2 OCH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  (CO).sub.2 OCH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHP(O)(OCH.sub.3).sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHP(O)(OCH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHP(O)(OCH.sub.3).sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHP(O)(OCH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHP(S)(CH.sub.3).sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHP(S)(CH.sub.3).sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHP(S)(CH.sub.3).sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHP(S)(CH.sub.3).sub.2                                                              OCH.sub. 3                                                                           OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHP(S)(SCH.sub.3).sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHP(S)(SCH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 NHP(S)(SCH.sub.3).sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 NHP(S)(SCH.sub.3).sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 --1-Naphthyl                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 --1-Naphthyl                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 --1-Naphthyl                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 --1-Naphthyl                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 --2-Naphthyl                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 --2-Naphthyl                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 --2-Naphthyl                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 --2-Naphthyl                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH(SCH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH(SCH.sub. 3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH(SCH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH(SCH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH(SCH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH(SCH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH(SCH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH(SCH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH(Cl)SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH(Cl)SO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH(Cl)SO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH(CI)SO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH(CN)OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH(CN)OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH(CN)OCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH(CN)OCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH(Cl)CH.sub.2 Cl                                                                   CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH(Cl)CH.sub.2 Cl                                                                   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH(Cl)CH.sub.2 Cl                                                                   CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH(Cl)CH.sub.2 Cl                                                                   OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C(CH.sub.3)═NOCH.sub.3                                                          CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C(CH.sub.3)═NOCH.sub.3                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C(CH.sub.3)═NOCH.sub.3                                                          CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C(CH.sub.3)═NOCH.sub.3                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C(CH.sub.3)═NOCH.sub.2 CH.sub.3                                                 CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C(CH.sub.3)═NOCH.sub.2 CH.sub.3                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C(CH.sub.3)═NOCH.sub.2 CH.sub.3                                                 CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C(CH.sub.3)═NOCH.sub.2 CH.sub.3                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CHC(O)CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CHC(O)CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CHC(O)CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CHC(O)CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CHC(O)OCH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CHC(O)OCH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CHC(O)OCH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CHC(O)OCH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH═CHN(CH.sub.3).sub.2                                                          CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH═CHN(CH.sub.3).sub.2                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH═CHN(CH.sub.3).sub.2                                                          CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH═CHN(CH.sub.3).sub.2                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CHC(O)NH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CHC(O)NH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CHC(O)NH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CHC(O)NH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═C(CH.sub.3)C(O)N(CH.sub.3).sub.2                                                      CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═C(CH.sub.3)C(O)N(CH.sub.3).sub.2                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═C(CH.sub.3)C(O)N(CH.sub.3).sub.2                                                      CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═C(CH.sub.3)C(O)N(CH.sub.3).sub.2                                                      OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CHP(O)(OCH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CHP(O)(OCH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CHP(O)(OCH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CHP(O)(OCH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH═CH(NO.sub.2)                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH═CH(NO.sub.2)                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH═CH(NO.sub.2)                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH═CH(NO.sub.2)                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CHCN    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CHCN    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CHCN    CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CHCN    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C.tbd.CC(O)CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C.tbd.CC(O)CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C.tbd.CC(O)CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C.tbd.CC(O)CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub. 2 C.tbd.CC(O)OCH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C.tbd.CC(O)OCH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C.tbd.CC(O)OCH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C.tbd.CC(O)OCH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C.tbd.CC(O)NHPh                                                                     CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C.tbd.CC(O)NHPh                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C.tbd.CC(O)NHPh                                                                     CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C.tbd.CC(O)NHPh                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CH--2-Thienyl                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CH--2-Thienyl                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CH--2-Thienyl                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CH--2-Thienyl                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CH--2-Pyridyl                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CH--2-Pyridyl                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CH--2-Pyridyl                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CH--2-Pyridyl                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CH--2-Cyclopentanone                                                                  CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CH--2-Cyclopentanone                                                                  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH═CH--2-Cyclopentanone                                                                  CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH═CH--2-Cyclopentanone                                                                  OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C.tbd.C--2-thienyl                                                                           CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C.tbd.C--2-thienyl                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C.tbd.C--2-thienyl                                                                           CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C.tbd.C--2-thienyl                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         H              CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         H              OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         H              CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         H              OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         CH.sub.3       CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         CH.sub.3       OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         CH.sub.3       CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         CH.sub.3       OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         CH.sub.2 CN    CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         CH.sub.2 CN    OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         CH.sub.2 CN    CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         CH.sub.2 CN    OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                   CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         C(O)CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         C(O)CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         C(O)CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         C(O)CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         C(O)OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         C(O)OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   CH.sub.3                                                                         C(O)OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   CH.sub.3                                                                         C(O)OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  H              H      OCH.sub.3                                                                           CH                                0  S  H  H   H  H              NHCH.sub.3                                                                           OCH.sub.3                                                                           N                                 0  S  H  H   H  H              NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                  N                                 0  S  H  H   H  H              OCH.sub.3                                                                            C.tbd.CH                                                                            CH                                0  S  H  H   H  H              OCH.sub.3                                                                            OCF.sub.2 H                                                                         CH                                0  S  H  H   H  H              OCH.sub.3                                                                            cyclopropyl                                                                         CH                                0  S  H  H   H  H              OCH.sub.3                                                                            OCH.sub.2 CF.sub.3                                                                  CH                                0  S  H  H   H  CH.sub.3       H      OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.3       NHCH.sub.3                                                                           OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.3       NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                  N                                 0  S  H  H   H  CH.sub.3       OCH.sub.3                                                                            C.tbd.CH                                                                            CH                                0  S  H  H   H  CH.sub.3       OCH.sub.3                                                                            OCF.sub.2 H                                                                         CH                                0  S  H  H   H  CH.sub.3       OCH.sub.3                                                                            cyclopropyl                                                                         CH                                0  S  H  H   H  CH.sub.3       OCH.sub.3                                                                            OCH.sub.2 CF.sub.3                                                                  CH                                0  S  H  H   H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           H      OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           NHCH.sub.3                                                                           OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                  N                                 0  S  H  H   H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            C.tbd.CH                                                                            CH                                0  S  H  H   H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            OCF.sub.2 H                                                                         CH                                0  S  H  H   H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            cyclopropyl                                                                         CH                                0  S  H  H   H  CH.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                           OCH.sub.3                                                                            OCH.sub.2 CF.sub.3                                                                  CH                                0  S  H  H   H  CH.sub.2 CH.sub.3                                                                            H      OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.3                                                                            NHCH.sub.3                                                                           OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.3                                                                            NHCH.sub.3                                                                           OCH.sub.2 CH.sub.3                                                                  N                                 0  S  H  H   H  CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            C.tbd.CH                                                                            CH                                0  S  H  H   H  CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            OCF.sub.2 H                                                                         CH                                0  S  H  H   H  CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            cyclopropyl                                                                         CH                                0  S  H  H   H  CH.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.2 CF.sub.3                                                                  CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 F                                                                          Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                             OCH.sub. 3                                                                          CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 F                                                                          CI     OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 F                                                                          Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 F                                                                          CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 CH.sub.2 F                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 Cl                                                                         Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 Cl                                                                         Cl     OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 Cl                                                                         Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 Cl                                                                         CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 CH.sub.2 Cl                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 Cl     OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 CH.sub.2 CH.sub.2 F                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 OCH.sub.3                                                                           Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 OCH.sub.3                                                                           Cl     OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 OCH.sub.3                                                                           Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 OCH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 OCH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 CH.sub.2 OCH.sub.3                                                                  OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)OCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  C(O)OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)OCH.sub.3  Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  C(O)OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  C(O)OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  C(O)OCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  CH.sub.3                                                                          H  C(O)OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  C(O)OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  C(O)OCH.sub.3  Cl     OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  C(O)OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  C(O)OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  Cl  H  C(O)OCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  C(O)OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  C(O)OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  C(O)OCH.sub.3  Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  C(O)OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  C(O)OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C(O)CH.sub.3                                                                        Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH C(O)CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 C(O)CH.sub.3                                                                        Cl     OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 C(O)CH.sub.3                                                                        Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CH.sub.2 C(O)CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CH.sub.2 C(O)CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  H   H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  H   H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  H   H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  H   H  CO.sub.2 CH.sub.3                                                                            Cl     OCH.sub.3                                                                           CH                                0  S  H  H   H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  H   H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  CH.sub.3                                                                          H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CO.sub.2 CH.sub.3                                                                            Cl     OCH.sub.3                                                                           CH                                0  S  H  CH.sub.3                                                                          H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  CH.sub.3                                                                          H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 0  S  H  CI  H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                            CH                                0  S  H  Cl  H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CO.sub.2 CH.sub.3                                                                            Cl     OCH.sub.3                                                                           CH                                0  S  H  Cl  H  CO.sub.2 CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                           N                                 0  S  H  Cl  H  CO.sub.2 CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                           N                                 __________________________________________________________________________

                                      TABLE Ii                                    __________________________________________________________________________    Structure Ii                                                                                                  m.p.                                          w G R R.sub.1                                                                          R.sub.7  R.sub.29                                                                         X   Y   Z  (°C.)                                  __________________________________________________________________________    O S H H  H        H  CH.sub.3                                                                          CH.sub.3                                                                          CH                                               O S H H  H        H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H H  H        H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  H        H  Cl  OCH.sub.3                                                                         CH                                               O S H H  H        H  Br  OCH.sub.3                                                                         CH                                               O S H H  H        H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H H  H        H  OCH.sub.3                                                                         OCH.sub.3                                                                         N                                                O S H H  CH.sub.3 H  CH.sub.3                                                                          CH.sub.3                                                                          CH 191-192                                       O S H H  CH.sub.3 H  CH.sub.3                                                                          OCH.sub.3                                                                         CH 175-176                                       O S H H  CH.sub.3 H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH 200-201                                       O S H H  CH.sub.3 H  Cl  OCH.sub.3                                                                         CH 189-190                                       O S H H  CH.sub.3 H  Br  OCH.sub.3                                                                         CH                                               O S H H  CH.sub.3 H  CH.sub.3                                                                          OCH.sub.3                                                                         N  176-177                                       O S H H  CH.sub.3 H  OCH.sub.3                                                                         OCH.sub.3                                                                         N  193-194                                       O S H CH.sub.3                                                                         CH.sub.3 H  CH.sub.3                                                                          CH.sub.3                                                                          CH                                               O S H CH.sub.3                                                                         CH.sub.3 H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H CH.sub.3                                                                         CH.sub.3 H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H CH.sub.3                                                                         CH.sub.3 H  Cl  OCH.sub.3                                                                         CH                                               O S H CH.sub.3                                                                         CH.sub.3 H  Br  OCH.sub.3                                                                         CH                                               O S H CH.sub.3                                                                         CH.sub.3 H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H CH.sub.3                                                                         CH.sub.3 H  OCH.sub.3                                                                         OCH.sub.3                                                                         N                                                O S H H  CH.sub.2 CH.sub.3                                                                      H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H H  CH.sub.2 CH.sub.3                                                                      H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H H  CH.sub.2 CH.sub.3                                                                      H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  (CH.sub.2).sub.5 CH.sub.3                                                              H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H Cl Cl       H  CH.sub.3                                                                          CH.sub.3                                                                          CH                                               O S H Cl Cl       H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H Cl Cl       H  OCH.sub.3                                                                         OCH.sub. 3                                                                        CH                                               O S H Cl Cl       H  Cl  OCH.sub.3                                                                         CH                                               O S H Cl Cl       H  Br  OCH.sub.3                                                                         CH                                               O S H Cl Cl       H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H Cl Cl       H  OCH.sub.3                                                                         OCH.sub.3                                                                         N                                                O S H H  Br       H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H H  Br       H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H H  Br       H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  CN       H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H H  CN       H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H H  CN       H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  NO.sub.2 H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H H  NO.sub.2 H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H H  NO.sub.2 H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  SCH.sub.3                                                                              H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H H  SCH.sub.3                                                                              H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H H  SCH.sub.3                                                                              H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  SO.sub.2 CH.sub.3                                                                      H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H H  SO.sub.2 CH.sub.3                                                                      H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H H  SO.sub.2 CH.sub.3                                                                      H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  CO.sub.2 CH.sub.3                                                                      H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H H  CO.sub.2 CH.sub.3                                                                      H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H H  CO.sub.2 CH.sub.3                                                                      H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  C(O)CH.sub.3                                                                           H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                                O S H H  C(O)CH.sub.3                                                                           H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                               O S H H  C(O)CH.sub.3                                                                           H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  C(O)(CH.sub.2).sub.3 CH.sub.3                                                          H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  CO.sub.2 CH.sub.2 Ph                                                                   H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  SO.sub.2 Ph                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               S S H H  CH.sub.3 H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  CH.sub.3 CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  CH.sub.3 Br OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               O S H H  Cl       Cl OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                               __________________________________________________________________________

                  TABLE Ij                                                        ______________________________________                                        Structure Ij                                                                                                                    m.p.                        w   G     R     R.sub.1 '                                                                          R.sub.7                                                                              R.sub.29                                                                           X     Y     Z    (°C.)                ______________________________________                                        O   S     H     H    H      H    CH.sub.3                                                                            CH.sub.3                                                                            CH                               O   S     H     H    H      H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               O   S     H     H    H      H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               O   S     H     H    H      H    Cl    OCH.sub.3                                                                           CH                               O   S     H     H    H      H    Br    OCH.sub.3                                                                           CH                               O   S     H     H    H      H    CH.sub.3                                                                            OCH.sub.3                                                                           N                                O   S     H     H    H      H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                O   S     H     H    CH.sub.3                                                                             H    CH.sub.3                                                                            CH.sub.3                                                                            CH                               O   S     H     H    CH.sub.3                                                                             H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               O   S     H     H    CH.sub.3                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               O   S     H     H    CH.sub.3                                                                             H    Cl    OCH.sub.3                                                                           CH                               O   S     H     H    CH.sub.3                                                                             H    Br    OCH.sub.3                                                                           CH                               O   S     H     H    CH.sub.3                                                                             H    CH.sub.3                                                                            OCH.sub.3                                                                           N                                O   S     H     H    CH.sub.3                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                           N                                O   S     H     H    CO.sub.2 CH.sub.3                                                                    H    CH.sub.3                                                                            OCH.sub.3                                                                           N                                O   S     H     H    CO.sub.2 CH.sub.3                                                                    H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                               O   S     H     H    CO.sub.2 CH.sub.3                                                                    H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               S   S     H     H    CH.sub.3                                                                             H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                               ______________________________________                                    

                                      TABLE Ik                                    __________________________________________________________________________    Structure Ik                                                                                                    m.p.                                        n W.sub.2                                                                          G   R R.sub.1                                                                          R.sub.4                                                                             R.sub.5                                                                          X   Y   Z  (°C.)                                __________________________________________________________________________    0 O  S   H H  H     H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                              0 O  S   H H  H     H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                             0 O  S   H H  H     H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             0 O  S   H H  CH.sub.3                                                                            H  CH.sub.3                                                                          OCH.sub.3                                                                         N                                              0 O  S   H H  CH.sub.3                                                                            H  CH.sub.3                                                                          OCH.sub.3                                                                         CH                                             0 O  S   H H  CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             0 O  S   H H  (CH.sub.2).sub.3 CH.sub.3                                                           H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             1 O  S   H H  CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             1 O  S   H H  CH.sub.3                                                                            CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             0 O  S   H CH.sub.3                                                                         CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             0 O  O   H CH.sub.3                                                                         CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             0 O  NH  H CH.sub.3                                                                         CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             0 O  NCH.sub.3                                                                         H CH.sub.3                                                                         CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             0 S  S   H H  CH.sub.3                                                                            H  OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             __________________________________________________________________________

                  TABLE Il                                                        ______________________________________                                        Structure Il                                                                                                                      m.p.                      n   W.sub.2                                                                              G     R   R.sub.1 '                                                                          R.sub.4                                                                            R.sub.5                                                                            X     Y     Z   (°C.)              ______________________________________                                        0   O      S     H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   O      S     H   H    H    H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   O      S     H   H    H    H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   O      S     H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           N                             0   O      S     H   H    CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                           CH                            0   O      S     H   H    CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            0   O      S     H   H    CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            1   O      S     H   H    CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                           CH                            ______________________________________                                    

                  TABLE Im                                                        ______________________________________                                        Structure Im                                                                                                                  m.p.                          n   G        R     R.sub.1                                                                            R.sub.5                                                                            X     Y      Z     (°C.)                  ______________________________________                                        1   S        H     H    H    CH.sub.3                                                                            OCH.sub.3                                                                            N                                   1   S        H     H    H    CH.sub.3                                                                            OCH.sub.3                                                                            CH                                  1   S        H     H    H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                  1   S        H     CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                            N                                   1   S        H     CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                            CH                                  1   S        H     CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                  1   O        H     CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                            N                                   1   O        H     CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                            CH                                  1   O        H     CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                  1   NH       H     CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                            N                                   1   NH       H     CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                            CH                                  1   NH       H     CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                  1   NCH.sub.3                                                                              H     CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                            N                                   1   NCH.sub.3                                                                              H     CH.sub.3                                                                           H    CH.sub.3                                                                            OCH.sub.3                                                                            CH                                  1   NCH.sub.3                                                                              H     CH.sub.3                                                                           H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                  1   S        H     H    CH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                  0   S        H     H    H    OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                  ______________________________________                                    

                  TABLE In                                                        ______________________________________                                        Structure In                                                                                                                 m.p.                           n   G      R     R.sub.1 '                                                                          R.sub.5                                                                             X      Y      Z    (°C.)                   ______________________________________                                        0   S      H     H    H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                   0   S      H     H    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  0   S      H     H    H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  1   S      H     H    H     CH.sub.3                                                                             OCH.sub.3                                                                            N                                   1   S      H     H    H     CH.sub.3                                                                             OCH.sub.3                                                                            CH                                  1   S      H     H    H     OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  1   S      H     H    CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                            CH                                  ______________________________________                                    

                  TABLE Io                                                        ______________________________________                                        Structure A, B, C, D, E, and F                                                J     G       R      R.sub.1                                                                             R.sub.1 '                                                                          R.sub.4                                                                            R.sub.5                                                                            R.sub.6                                                                            W.sub.2                        ______________________________________                                        J-9   S       H      H     --   H    --   --   O                              J-9   S       H      CH.sub.3                                                                            --   H    --   --   O                              J-9   O       H      CH.sub.3                                                                            --   H    --   --   O                              J-9   NH      H      CH.sub.3                                                                            --   H    --   --   O                              J-9   NCH.sub.3                                                                             H      CH.sub.3                                                                            --   H    --   --   O                              J-10  S       H      --    H    H    --   --   O                              J-11  S       H      H     --   --   H    CH.sub.3                                                                           --                             J-11  S       H      CH.sub.3                                                                            --   --   H    CH.sub.3                                                                           --                             J-11  O       H      CH.sub.3                                                                            --   --   H    CH.sub.3                                                                           --                             J-11  NH      H      CH.sub.3                                                                            --   --   H    CH.sub.3                                                                           --                             J-11  NCH.sub.3                                                                             H      CH.sub.3                                                                            --   --   H    CH.sub.3                                                                           --                             J-12  S       H      --    H    --   H    CH.sub.3                                                                           --                             J-19  S       H      H     --   CH.sub.3                                                                           H    --   O                              J-19  S       H      CH.sub.3                                                                            --   CH.sub.3                                                                           H    --   O                              J-19  O       H      CH.sub.3                                                                            --   CH.sub.3                                                                           H    --   O                              J-19  NH      H      CH.sub.3                                                                            --   CH.sub.3                                                                           H    --   O                              J-19  NCH.sub.3                                                                             H      CH.sub.3                                                                            --   CH.sub.3                                                                           H    --   O                              J-20  S       H      --    H    CH.sub.3                                                                           H    --   O                              J-21  S       H      H     --   --   H    --   --                             J-21  S       H      CH.sub.3                                                                            --   --   H    --   --                             J-21  O       H      CH.sub.3                                                                            --   --   H    --   --                             J-21  NH      H      CH.sub.3                                                                            --   --   H    --   --                             J-21  NCH.sub.3                                                                             H      CH.sub.3                                                                            --   --   H    --   --                             J-22  S       H      --    H    --   H    --   --                             ______________________________________                                    

                                      TABLE Ip                                    __________________________________________________________________________    Structure Ip                                                                                                    m.p.                                        J W.sub.2                                                                          G   n Q  R.sub.1 (R.sub.1 ')                                                               R.sub.2                                                                          R.sub.3                                                                         X   Y   Z  (°C.)                                __________________________________________________________________________    J-1                                                                             -- S   1 S  H   H  H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-1                                                                             -- S   0 S  H   CH.sub.3                                                                         H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-1                                                                             -- S   0 SO.sub.2                                                                         H   CH.sub.3                                                                         H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-1                                                                             -- O   0 SO.sub.2                                                                         CH.sub.3                                                                          H  H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-1                                                                             -- NH  0 SO.sub.2                                                                         CH.sub.3                                                                          H  H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-1                                                                             -- NCH.sub.3                                                                         0 SO.sub.2                                                                         CH.sub.3                                                                          H  H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-1                                                                             -- S   0 SO.sub.2                                                                         H   CH.sub.3                                                                         H CH.sub.3                                                                          OCH.sub.3                                                                         N                                              J-2                                                                             -- S   0 SO.sub.2                                                                         H   CH.sub.3                                                                         H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-3                                                                             O  S   1 -- H   H  H OCH.sub. 3                                                                        OCH.sub.3                                                                         CH                                             J-3                                                                             O  S   1 -- CH.sub.3                                                                          H  H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-3                                                                             O  O   1 -- CH.sub.3                                                                          H  H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-3                                                                             O  NH  1 -- CH.sub.3                                                                          H  H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-3                                                                             O  NCH.sub.3                                                                         1 -- CH.sub.3                                                                          H  H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-4                                                                             O  S   1 -- H   H  H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             J-4                                                                             O  S   0 -- H   H  H OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                             __________________________________________________________________________

                                      TABLE Iq                                    __________________________________________________________________________    Structure Iq                                                                                                     m.p.                                       J  W.sub.2                                                                          G   n R.sub.1 (R.sub.1 ')                                                               R.sub.4                                                                          R.sub.5                                                                         R.sub.6                                                                          X   Y   Z  (°C.)                               __________________________________________________________________________    J-5                                                                              O  S   1 H   H  H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-5                                                                              O  S   1 CH.sub.3                                                                          H  H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-5                                                                              O  O   1 CH.sub.3                                                                          H  H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-5                                                                              O  NH  1 CH.sub.3                                                                          H  H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-5                                                                              O  NCH.sub.3                                                                         1 CH.sub.3                                                                          H  H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-5                                                                              O  S   0 H   H  H -- CH.sub.3                                                                          OCH.sub.3                                                                         N                                             J-6                                                                              O  S   1 H   H  H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-6                                                                              O  S   1 Cl  H  H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-7                                                                              -- S   0 H   -- H CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-7                                                                              -- O   0 H   -- H CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-7                                                                              -- S   1 H   -- H CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-8                                                                              -- S   0 H   -- H CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-9                                                                              O  S   --                                                                              CH.sub.3                                                                          H  --                                                                              -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-9                                                                              O  O   --                                                                              CH.sub.3                                                                          H  --                                                                              -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-9                                                                              O  NH  --                                                                              CH.sub.3                                                                          H  --                                                                              -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-9                                                                              O  NCH.sub.3                                                                         --                                                                              CH.sub.3                                                                          H  --                                                                              -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-9                                                                              O  S   --                                                                              H   H  --                                                                              -- CH.sub.3                                                                          OCH.sub.3                                                                         N                                             J-10                                                                             O  S   --                                                                              H   H  --                                                                              -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-11                                                                             -- S   --                                                                              H   -- H CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-12                                                                             -- S   --                                                                              H   -- H CH.sub.3                                                                         OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-15                                                                             O  S   1 H   CH.sub.3                                                                         H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-15                                                                             O  S   0 H   CH.sub.3                                                                         H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-16                                                                             O  S   0 H   CH.sub.3                                                                         H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-17                                                                             -- S   --                                                                              H   -- H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-18                                                                             -- S   --                                                                              H   -- H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-19                                                                             O  S   --                                                                              H   CH.sub.3                                                                         H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-20                                                                             O  S   --                                                                              H   CH.sub.3                                                                         H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-21                                                                             -- S   --                                                                              H   -- H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            J-22                                                                             -- S   --                                                                              H   -- H -- OCH.sub.3                                                                         OCH.sub.3                                                                         CH                                            __________________________________________________________________________

                                      TABLE IIa                                   __________________________________________________________________________    Structure IIa                                                                                                      m.p.                                     J W.sub.2                                                                          G  Q    n R  R.sub.1 (R.sub.1 ')                                                               R.sub.2                                                                          R.sub.3                                                                          X.sub.1                                                                             Y.sub.1                                                                          (°C.)                             __________________________________________________________________________    J.sub.1                                                                         -- S  O    0 H  H   H  H  CH.sub.3                                                                            O                                           J.sub.1                                                                         -- S  O    0 H  H   H  CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.2                                    J.sub.1                                                                         -- S  O    0 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  O                                           J.sub.1                                                                         -- S  O    1 H  H   H  H  OCF.sub.2 H                                                                         CH.sub.2                                    J.sub.1                                                                         -- S  O    1 H  H   H  CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2                                    J.sub.1                                                                         -- S  O    1 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                                                           O                                           J.sub.1                                                                         -- S  S    0 H  H   H  H  OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                    J.sub.1                                                                         -- S  S    0 H  H   H  CH.sub.3                                                                         OCF.sub.2 H                                                                         O                                           J.sub.1                                                                         -- S  S    0 H  H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                            O                                           J.sub.1                                                                         -- S  S    1 H  H   H  H  OCH.sub.3                                                                           CH.sub.2                                    J.sub.1                                                                         -- S  S    1 H  H   H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  O                                           J.sub.1                                                                         -- S  S    1 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                                                         CH.sub.2                                    J.sub.1                                                                         -- S  SO.sub.2                                                                           0 H  H   H  H  CH.sub.3                                                                            CH.sub.2                                    J.sub.1                                                                         -- O  SO.sub.2                                                                           0 H  H   H  CH.sub.3                                                                         OCH.sub.3                                                                           O                                           J.sub.1                                                                         -- NH SO.sub.2                                                                           0 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                    J.sub.1                                                                         -- S  SO.sub.2                                                                           1 H  H   H  H  OCF.sub.2 H                                                                         O                                           J.sub.1                                                                         -- S  SO.sub.2                                                                           1 H  H   H  CH.sub.3                                                                         CH.sub.3                                                                            O                                           J.sub.1                                                                         -- S  SO.sub.2                                                                           1 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.2                                    J.sub.2                                                                         -- S  O    0 H  H   H  H  OCH.sub.2 CH.sub.3                                                                  O                                           J.sub.2                                                                         -- S  O    0 H  H   H  CH.sub.3                                                                         OCF.sub.2 H                                                                         CH.sub.2                                    J.sub.2                                                                         -- S  O    0 H  H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2                                    J.sub.2                                                                         -- S  O    1 H  H   H  H  OCH.sub.3                                                                           O                                           J.sub.2                                                                         -- S  O    1 H  H   H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                    J.sub.2                                                                         -- S  O    1 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                                                         O                                           J.sub.2                                                                         -- S  S    0 H  H   H  H  CH.sub.3                                                                            O                                           J.sub.2                                                                         -- S  S    0 H  H   H  CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.2                                    J.sub.2                                                                         -- S  S    0 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  O                                           J.sub.2                                                                         -- S  S    1 H  H   H  H  OCF.sub.2 H                                                                         CH.sub.2                                    J.sub.2                                                                         -- S  S    1 H  H   H  CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2                                    J.sub.2                                                                         -- S  S    1 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                                                           O                                           J.sub.2                                                                         -- S  SO.sub.2                                                                           0 H  H   H  H  OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                    J.sub.2                                                                         -- S  SO.sub.2                                                                           0 H  H   H  CH.sub.3                                                                         OCF.sub.2 H                                                                         O                                           J.sub.2                                                                         -- S  SO.sub.2                                                                           0 H  H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                            O                                           J.sub.2                                                                         -- S  SO.sub.2                                                                           1 H  H   H  H  OCH.sub.3                                                                           CH.sub.2                                    J.sub.2                                                                         -- S  SO.sub.2                                                                           1 H  H   H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  O                                           J.sub.2                                                                         -- S  SO.sub.2                                                                           1 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                                                         CH.sub.2                                    J.sub.3                                                                         O  S  --   0 H  H   H  H  CH.sub.3                                                                            CH.sub.2                                    J.sub.3                                                                         O  S  --   0 H  H   H  CH.sub.3                                                                         OCH.sub.3                                                                           O                                           J.sub.3                                                                         O  S  --   0 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                    J.sub.3                                                                         O  S  --   1 H  H   H  H  OCF.sub.2 H                                                                         O                                           J.sub.3                                                                         O  S  --   1 H  H   H  CH.sub.3                                                                         CH.sub.3                                                                            O                                           J.sub.3                                                                         O  S  --   1 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.2                                    J.sub.4                                                                         O  S  --   0 H  H   H  H  OCH.sub.2 CH.sub.3                                                                  O                                           J.sub.4                                                                         O  S  --   0 H  H   H  CH.sub.3                                                                         OCF.sub.2 H                                                                         CH.sub.2                                    J.sub.4                                                                         O  S  --   0 H  H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2                                    J.sub.4                                                                         O  S  --   1 H  H   H  H  OCH.sub.3                                                                           O                                           J.sub.4                                                                         O  S  --   1 H  H   H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                    J.sub.4                                                                         O  S  --   1 H  H   CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                                                         O                                           J.sub.1                                                                         -- S  CH.sub.2                                                                           0 H  H   H  H  CH.sub.3                                                                            O                                           J.sub.1                                                                         -- S  CH.sub.2                                                                           0 H  H   H  CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.2                                    J.sub.1                                                                         -- S  CHCH.sub.3                                                                         0 H  H   H  H  OCH.sub.2 CH.sub.3                                                                  O                                           J.sub.1                                                                         -- S  CH.sub.2                                                                           1 H  H   H  H  OCF.sub.2 H                                                                         CH.sub.2                                    J.sub.1                                                                         -- S  CH.sub.2                                                                           1 H  H   H  CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2                                    J.sub.1                                                                         -- S  CHCH.sub.3                                                                         1 H  H   H  H  OCH.sub.3                                                                           O                                           J.sub.13                                                                        -- S  --   --                                                                              H  H   H  -- OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                    J.sub.13                                                                        -- S  --   --                                                                              H  H   Cl -- OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                    J.sub.14                                                                        -- S  --   --                                                                              H  H   H  -- OCF.sub.2 H                                                                         O                                           J.sub.14                                                                        -- S  --   --                                                                              H  H   Cl -- OCF.sub.2 H                                                                         O                                           __________________________________________________________________________

                                      TABLE IIb                                   __________________________________________________________________________    Structure IIb                                                                                                   m.p.                                        J  W.sub.2                                                                          G n R R.sub.1 (R.sub.1 ')                                                               R.sub.4                                                                          R.sub.5                                                                          R.sub.6                                                                          X.sub.1                                                                             Y.sub.1                                                                          (°C.)                                __________________________________________________________________________    J.sub.5                                                                          O  S 0 H H   H  H  -- CH.sub.3                                                                            CH.sub.2                                       J.sub.5                                                                          O  S 0 H H   H  CH.sub.3                                                                         -- OCH.sub.3                                                                           O                                              J.sub.5                                                                          O  S 0 H H   H  CH.sub.3                                                                         -- OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                       J.sub.5                                                                          O  S 1 H H   H  H  -- OCF.sub.2 H                                                                         O                                              J.sub.5                                                                          O  S 1 H H   CH.sub.3                                                                         H  -- CH.sub.3                                                                            O                                              J.sub.5                                                                          O  S 1 H H   CH.sub.3                                                                         CH.sub.3                                                                         -- OCH.sub.3                                                                           CH.sub.2                                       J.sub.6                                                                          O  S 0 H H   H  H  -- OCH.sub.2 CH.sub.3                                                                  O                                              J.sub.6                                                                          O  S 0 H H   H  CH.sub.3                                                                         -- OCF.sub.2 H                                                                         CH.sub.2                                       J.sub.6                                                                          O  S 0 H H   H  CH.sub.3                                                                         -- CH.sub.3                                                                            CH.sub.2                                       J.sub.6                                                                          O  S 1 H H   H  H  -- OCH.sub.3                                                                           O                                              J.sub.6                                                                          O  S 1 H H   CH.sub.3                                                                         H  -- OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                       J.sub.6                                                                          O  S 1 H H   CH.sub.3                                                                         CH.sub.3                                                                         -- OCF.sub.2 H                                                                         O                                              J.sub.7                                                                          -- S 0 H H   -- H  CH.sub.3                                                                         CH.sub.3                                                                            O                                              J.sub.7                                                                          -- S 0 H H   -- CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                                                           CH.sub.2                                       J.sub.7                                                                          -- S 1 H H   -- H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  O                                              J.sub.7                                                                          -- S 1 H H   -- CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                                                         CH.sub.2                                       J.sub.8                                                                          -- S 0 H H   -- H  CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2                                       J.sub.8                                                                          -- S 0 H H   -- CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                                                           O                                              J.sub.8                                                                          -- S 1 H H   -- H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                       J.sub.8                                                                          -- S 1 H H   -- CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                                                         O                                              J.sub.9                                                                          O  S --                                                                              H H   H  -- -- CH.sub.3                                                                            O                                              J.sub.9                                                                          O  S --                                                                              H H   CH.sub.3                                                                         -- -- OCH.sub.3                                                                           CH.sub.2                                       J.sub.10                                                                         O  S --                                                                              H H   H  -- -- OCH.sub.2 CH.sub.3                                                                  O                                              J.sub.10                                                                         O  S --                                                                              H H   CH.sub.3                                                                         -- -- OCF.sub.2 H                                                                         CH.sub.2                                       J.sub.11                                                                         -- S --                                                                              H H   -- H  CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2                                       J.sub.11                                                                         -- S --                                                                              H H   -- CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                                                           O                                              J.sub.12                                                                         -- S --                                                                              H H   -- H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                  CH.sub.2                                       J.sub.12                                                                         -- S --                                                                              H H   -- CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                                                         O                                              J.sub.15                                                                         O  S 1 H H   CH.sub.3                                                                         H  -- OCH.sub.3                                                                           O                                              J.sub.16                                                                         O  S 1 H H   CH.sub.3                                                                         H  -- OCH.sub.3                                                                           O                                              J.sub.17                                                                         -- S --                                                                              H H   -- H  -- OCH.sub.3                                                                           O                                              J.sub.18                                                                         -- S --                                                                              H H   -- H  -- OCH.sub.3                                                                           O                                              J.sub.19                                                                         O  S --                                                                              H H   CH.sub.3                                                                         H  -- OCH.sub.3                                                                           O                                              J.sub.20                                                                         O  S --                                                                              H H   CH.sub.3                                                                         H  -- OCH.sub.3                                                                           O                                              J.sub.21                                                                         -- S --                                                                              H H   -- H  -- OCH.sub.3                                                                           O                                              J.sub.22                                                                         -- S --                                                                              H H   -- H  -- OCH.sub.3                                                                           O                                              __________________________________________________________________________

                                      TABLE IIIa                                  __________________________________________________________________________    Structure IIIa                                                                                                    m.p.                                      J  W.sub.2                                                                          G Q     n R R.sub.1 (R.sub.1 ')                                                                R.sub.2                                                                          R.sub.3                                                                          X.sub.1                                                                              (°C.)                              __________________________________________________________________________    J.sub.1                                                                          -- S O     0 H H    H  H  CH.sub.3                                         J.sub.1                                                                          -- S O     0 H H    H  CH.sub.3                                                                         OCH.sub.3                                        J.sub.1                                                                          -- S O     0 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                               J.sub.1                                                                          -- S O     1 H H    H  H  OCF.sub.2 H                                      J.sub.1                                                                          -- S O     1 H H    H  CH.sub.3                                                                         CH.sub.3                                         J.sub.1                                                                          -- S O     1 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                        J.sub.1                                                                          -- S S     0 H H    H  H  OCH.sub.2 CH.sub.3                               J.sub.1                                                                          -- S S     0 H H    H  CH.sub.3                                                                         OCF.sub.2 H                                      J.sub.1                                                                          -- S S     0 H H    CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                         J.sub.1                                                                          -- S S     1 H H    H  H  OCH.sub.3                                        J.sub.1                                                                          -- S S     1 H H    H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                               J.sub.1                                                                          -- S S     1 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                      J.sub.1                                                                          -- S SO.sub.2                                                                            0 H H    H  H  CH.sub.3                                         J.sub.1                                                                          -- S SO.sub.2                                                                            0 H H    H  CH.sub.3                                                                         OCH.sub.3                                        J.sub.1                                                                          -- S SO.sub.2                                                                            0 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                               J.sub.1                                                                          -- S SO.sub.2                                                                            1 H H    H  H  OCF.sub.2 H                                      J.sub.1                                                                          -- S SO.sub.2                                                                            1 H H    H  CH.sub.3                                                                         CH.sub.3                                         J.sub.1                                                                          -- S SO.sub.2                                                                            1 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                        J.sub.2                                                                          -- S O     0 H H    H  H  OCH.sub.2 CH.sub.3                               J.sub.2                                                                          -- S O     0 H H    H  CH.sub.3                                                                         OCF.sub.2 H                                      J.sub.2                                                                          -- S O     0 H H    CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                         J.sub.2                                                                          -- S O     1 H H    H  H  OCH.sub.3                                        J.sub.2                                                                          -- S O     1 H H    H  CH.sub. 3                                                                        OCH.sub.2 CH.sub.3                               J.sub.2                                                                          -- S O     1 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                      J.sub.2                                                                          -- S S     0 H H    H  H  CH.sub.3                                         J.sub.2                                                                          -- S S     0 H H    H  CH.sub.3                                                                         OCH.sub.3                                        J.sub.2                                                                          -- S S     0 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                               J.sub.2                                                                          -- S S     1 H H    H  H.sub.2                                                                          OCF H                                            J.sub.2                                                                          -- S S     1 H H    H  CH.sub.3                                                                         CH.sub.3                                         J.sub.2                                                                          -- S S     1 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                        J.sub.2                                                                          -- S SO.sub.2                                                                            0 H H    H  H  OCH.sub.2 CH.sub.3                               J.sub.2                                                                          -- S SO.sub.2                                                                            0 H H    H  CH.sub.3                                                                         OCF.sub.2 H                                      J.sub.2                                                                          -- S SO.sub.2                                                                            0 H H    CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                         J.sub.2                                                                          -- S SO.sub.2                                                                            1 H H    H  H  OCH.sub.3                                        J.sub.2                                                                          -- S SO.sub.2                                                                            1 H H    H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                               J.sub.2                                                                          -- S SO.sub.2                                                                            1 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                      J.sub.3                                                                          O  S --    0 H H    H  H  CH.sub.3                                         J.sub.3                                                                          O  S --    0 H H    H  CH.sub.3                                                                         OCH.sub.3                                        J.sub.3                                                                          O  S --    0 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                               J.sub.3                                                                          O  S --    1 H H    H  H  OCF.sub.2 H                                      J.sub.3                                                                          O  S --    1 H H    H  CH.sub.3                                                                         CH.sub.3                                         J.sub.3                                                                          O  S --    1 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                        J.sub.4                                                                          O  S --    0 H H    H  H  OCH.sub.2 CH.sub.3                               J.sub.4                                                                          O  S '     0 H H    H  CH.sub.3                                                                         OCF.sub.2 H                                      J.sub.4                                                                          O  S --    0 H H    CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                         J.sub.4                                                                          O  S --    1 H H    H  H  OCH.sub.3                                        J.sub.4                                                                          O  S --    1 H H    H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                               J.sub.4                                                                          O  S --    1 H H    CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                      J.sub.1                                                                          -- S CH.sub.2                                                                            0 H H    H  H  CH.sub.3                                         J.sub.1                                                                          -- S CH.sub.2                                                                            0 H H    H  CH.sub.3                                                                         OCH.sub.3                                        J.sub.1                                                                          -- S CHCH.sub.3                                                                          0 H H    H  H  OCH.sub.2 CH.sub.3                               J.sub.1                                                                          -- S CH.sub.2                                                                            1 H H    H  H  OCF.sub.2 H                                      J.sub.1                                                                          -- S CH.sub.2                                                                            1 H H    H  CH.sub.3                                                                         CH.sub.3                                         J.sub.1                                                                          -- S CHCH.sub.3                                                                          1 H H    H  H  OCH.sub.3                                        J.sub.13                                                                         -- S --    --                                                                              H H    H  -- OCH.sub.2 CH.sub.3                               J.sub.13                                                                         -- S --    --                                                                              H H    Cl -- OCH.sub.2 CH.sub.3                               J.sub.14                                                                         -- S --    --                                                                              H H    H  -- OCF.sub.2 H                                      J.sub.14                                                                         -- S --    --                                                                              H H    Cl -- OCF.sub.2 H                                      __________________________________________________________________________

                  TABLE IIIb                                                      ______________________________________                                        Structure IIIb                                                                                     R.sub.1                      m.p.                        J   W.sub.2                                                                              G     n   R (R.sub.1 ')                                                                       R.sub.4                                                                            R.sub.5                                                                            R.sub.6 X.sub.1                                                                            (°C.)                ______________________________________                                        J.sub.5                                                                           O      S     0   H H   H    H    --      CH.sub.3                         J.sub.5                                                                           O      S     0   H H   H    CH.sub.3                                                                           --      OCH.sub.3                        J.sub.5                                                                           O      S     0   H H   H    CH.sub.3                                                                           --      OCH.sub.2 CH.sub.3               J.sub.5                                                                           O      S     1   H H   H    H    --      OCF.sub.2 H                      J.sub.5                                                                           O      S     1   H H   CH.sub.3                                                                           H    --      CH.sub.3                         J.sub.5                                                                           O      S     1   H H   CH.sub.3                                                                           CH.sub.3                                                                           --      OCH.sub.3                        J.sub.6                                                                           O      S     0   H H   H    H    --      OCH.sub.2 CH.sub.3               J.sub.6                                                                           O      S     0   H H   H    CH.sub.3                                                                           --      OCF.sub.2 H                      J.sub.6                                                                           O      S     0   H H   H    CH.sub.3                                                                           --      CH.sub.3                         J.sub.6                                                                           O      S     1   H H   H    H    --      OCH.sub.3                        J.sub.6                                                                           O      S     1   H H   CH.sub.3                                                                           H    --      OCH.sub.2 CH.sub.3               J.sub.6                                                                           O      S     1   H H   CH.sub.3                                                                           CH.sub.3                                                                           --      OCF.sub.2 H                      J.sub.7                                                                           --     S     0   H H   --   H    CH.sub.3                                                                              CH.sub.3                         J.sub.7                                                                           --     S     0   H H   --   CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.3                        J.sub.7                                                                           --     S     1   H H   --   H    CH.sub.3                                                                              OCH.sub.2 CH.sub.3               J.sub.7                                                                           --     S     1   H H   --   CH.sub.3                                                                           CH.sub.3                                                                              OCF.sub.2 H                      J.sub.8                                                                           --     S     0   H H   --   H    CH.sub.3                                                                              CH.sub.3                         J.sub.8                                                                           --     S     0   H H   --   CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.3                        J.sub.8                                                                           --     S     1   H H   --   H    CH.sub.3                                                                              OCH.sub.2 CH.sub.3               J.sub.8                                                                           --     S     1   H H   --   CH.sub.3                                                                           CH.sub.3                                                                              OCF.sub.2 H                      J.sub.9                                                                           O      S     --  H H   H    --   --      CH.sub.3                         J.sub.9                                                                           O      S     --  H H   CH.sub.3                                                                           --   --      OCH.sub.3                        J.sub.10                                                                          O      S     --  H H   H    --   --      OCH.sub.2 CH.sub.3               J.sub.10                                                                          O      S     --  H H   CH.sub.3                                                                           --   --      OCF.sub.2 H                      J.sub.11                                                                          --     S     --  H H   --   H    CH.sub.3                                                                              CH.sub.3                         J.sub.11                                                                          --     S     --  H H   --   CH.sub.3                                                                           CH.sub.3                                                                              OCH.sub.3                        J.sub.12                                                                          --     S     --  H H   --   H    CH.sub.3                                                                              OCH.sub.2 CH.sub.3               J.sub.12                                                                          --     S     --  H H   --   CH.sub.3                                                                           CH.sub.3                                                                              OCF.sub.2 H                      J.sub.15                                                                          O      S     1   H H   CH.sub.3                                                                           H    --      OCH.sub.3                        J.sub.16                                                                          O      S     1   H H   CH.sub.3                                                                           H    --      OCH.sub.3                        J.sub.17                                                                          --     S     --  H H   --   H    --      OCH.sub.3                        J.sub.18                                                                          --     S     --  H H   --   H    --      OCH.sub.3                        J.sub.19                                                                          O      S     --  H H   CH.sub.3                                                                           H    --      OCH.sub.3                        J.sub.20                                                                          O      S     --  H H   CH.sub.3                                                                           H    --      OCH.sub.3                        J.sub.21                                                                          --     S     --  H H   --   H    --      OCH.sub.3                        J.sub.22                                                                          --     S     --  H H   --   H    --      OCH.sub.3                        ______________________________________                                    

                                      TABLE IVa                                   __________________________________________________________________________    Structure IVa                                                                                                     m.p.                                      J  W.sub.2                                                                          G Q    n R R.sub.1 (R.sub.1 ')                                                                R.sub.4                                                                         R.sub.5                                                                          R.sub.6                                                                          X.sub.1                                                                             (°C.)                              __________________________________________________________________________    J.sub.1                                                                          -- S O    0 H H    H H  H  CH.sub.3                                        J.sub.1                                                                          -- S O    0 H H    H H  CH.sub.3                                                                         OCH.sub.3                                       J.sub.1                                                                          -- S O    0 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                              J.sub.1                                                                          -- S O    1 H H    H H  H  OCF.sub.2 H                                     J.sub.1                                                                          -- S O    1 H H    H H  CH.sub.3                                                                         CH.sub.3                                        J.sub.1                                                                          -- S O    1 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                       J.sub.1                                                                          -- S S    0 H H    H H  H  OCH.sub.2 CH.sub.3                              J.sub.1                                                                          -- S S    0 H H    H H  CH.sub.3                                                                         OCF.sub.2 H                                     J.sub.1                                                                          -- S S    0 H H    H CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                        J.sub.1                                                                          -- S S    1 H H    H H  H  OCH.sub.3                                       J.sub.1                                                                          -- S S    1 H H    H H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                              J.sub.1                                                                          -- S S    1 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                     J.sub.1                                                                          -- S SO.sub.2                                                                           0 H H    H H  H  CH.sub.3                                        J.sub.1                                                                          -- S SO.sub.2                                                                           0 H H    H H  CH.sub.3                                                                         OCH.sub.3                                       J.sub.1                                                                          -- S SO.sub.2                                                                           0 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                              J.sub.1                                                                          -- S SO.sub.2                                                                           1 H H    H H  H  OCF.sub.2 H                                     J.sub.1                                                                          -- S SO.sub.2                                                                           1 H H    H H  CH.sub.3                                                                         CH.sub.3                                        J.sub.1                                                                          -- S SO.sub.2                                                                           1 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                       J.sub.2                                                                          -- S O    0 H H    H H  H  OCH.sub.2 CH.sub.3                              J.sub.2                                                                          -- S O    0 H H    H H  CH.sub.3                                                                         OCF.sub.2 H                                     J.sub.2                                                                          -- S O    0 H H    H CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                        J.sub.2                                                                          -- S O    1 H H    H H  H  OCH.sub.3                                       J.sub.2                                                                          -- S O    1 H H    H H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                              J.sub.2                                                                          -- S O    1 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                     J.sub.2                                                                          -- S S    0 H H    H H  H  CH.sub.3                                        J.sub.2                                                                          -- S S    0 H H    H H  CH.sub.3                                                                         OCH.sub.3                                       J.sub.2                                                                          -- S S    0 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                              J.sub.2                                                                          -- S S    1 H H    H H  H  OCF.sub.2 H                                     J.sub.2                                                                          -- S S    1 H H    H H  CH.sub.3                                                                         CH.sub.3                                        J.sub.2                                                                          -- S S    1 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                       J.sub.2                                                                          -- S SO.sub.2                                                                           0 H H    H H  H  OCH.sub.2 CH.sub.3                              J.sub.2                                                                          -- S SO.sub.2                                                                           0 H H    H H  CH.sub.3                                                                         OCF.sub.2 H                                     J.sub.2                                                                          -- S SO.sub.2                                                                           0 H H    H CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                        J.sub.2                                                                          -- S SO.sub. 2                                                                          1 H H    H H  H  OCH.sub.3                                       J.sub.2                                                                          -- S SO.sub.2                                                                           1 H H    H H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                              J.sub.2                                                                          -- S SO.sub.2                                                                           1 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                     J.sub.3                                                                          O  S --   0 H H    H H  H  CH.sub.3                                        J.sub.3                                                                          O  S --   0 H H    H H  CH.sub.3                                                                         OCH.sub.3                                       J.sub.3                                                                          O  S --   0 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.2 CH.sub.3                              J.sub.3                                                                          O  S --   1 H H    H H  H  OCF.sub.2 H                                     J.sub.3                                                                          O  S --   1 H H    H H  CH.sub.3                                                                         CH.sub.3                                        J.sub.3                                                                          O  S --   1 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCH.sub.3                                       J.sub.4                                                                          O  S --   0 H H    H H  H  OCH.sub.2 CH.sub.3                              J.sub.4                                                                          O  S --   0 H H    H H  CH.sub.3                                                                         OCF.sub.2 H                                     J.sub.4                                                                          O  S --   0 H H    H CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                        J.sub.4                                                                          O  S --   1 H H    H H  H  OCH.sub.3                                       J.sub.4                                                                          O  S --   1 H H    H H  CH.sub.3                                                                         OCH.sub.2 CH.sub.3                              J.sub.4                                                                          O  S --   1 H H    H CH.sub.3                                                                         CH.sub.3                                                                         OCF.sub.2 H                                     J.sub.1                                                                          -- S CH.sub.2                                                                           0 H H    H H  H  CH.sub.3                                        J.sub.1                                                                          -- S CH.sub.2                                                                           0 H H    H H  CH.sub.3                                                                         OCH.sub.3                                       J.sub.1                                                                          -- S CHCH.sub.3                                                                         0 H H    H H  H  OCH.sub.2 CH.sub.3                              J.sub.1                                                                          -- S CH.sub.2                                                                           1 H H    H H  H  OCF.sub.2 H                                     J.sub.1                                                                          -- S CH.sub.2                                                                           1 H H    H H  CH.sub.3                                                                         CH.sub.3                                        J.sub.1                                                                          -- S CHCH.sub.3                                                                         1 H H    H H  H  OCH.sub.3                                       J.sub.13                                                                         -- S --   --                                                                              H H    H H  -- OCH.sub.2 CH.sub.3                              J.sub.13                                                                         -- S --   --                                                                              H H    H Cl -- OCH.sub.2 CH.sub.3                              J.sub.14                                                                         -- S --   --                                                                              H H    H H  -- OCF.sub.2 H                                     J.sub.14                                                                         -- S --   --                                                                              H H    H Cl -- OCF.sub.2 H                                     __________________________________________________________________________

                  TABLE IVb                                                       ______________________________________                                        Structure IVb                                                                                      R.sub.1                      m.p.                        J    W.sub.2                                                                             G     n   R (R.sub.1 ')                                                                       R.sub.4                                                                            R.sub.5                                                                            R.sub.6                                                                            X.sub.1 (°C.)                ______________________________________                                        J.sub.5                                                                            O     S     0   H H   H    H    --   CH.sub.3                            J.sub.5                                                                            O     S     0   H H   H    CH.sub.3                                                                           --   OCH.sub.3                           J.sub.5                                                                            O     S     0   H H   H    CH.sub.3                                                                           --   OCH.sub.2 CH.sub.3                  J.sub.5                                                                            O     S     1   H H   H    H    --   OCF.sub.2 H                         J.sub.5                                                                            O     S     1   H H   CH.sub.3                                                                           H    --   CH.sub.3                            J.sub.5                                                                            O     S     1   H H   CH.sub.3                                                                           CH.sub.3                                                                           --   OCH.sub.3                           J.sub.6                                                                            O     S     0   H H   H    H    --   OCH.sub.2 CH.sub.3                  J.sub.6                                                                            O     S     0   H H   H    CH.sub.3                                                                           --   OCF.sub.2 H                         J.sub.6                                                                            O     S     0   H H   H    CH.sub.3                                                                           --   CH.sub.3                            J.sub.6                                                                            O     S     1   H H   H    H    --   OCH.sub.3                           J.sub.6                                                                            O     S     1   H H   CH.sub.3                                                                           H    --   OCH.sub.2 CH.sub.3                  J.sub.6                                                                            O     S     1   H H   CH.sub.3                                                                           CH.sub.3                                                                           --   OCF.sub.2 H                         J.sub.7                                                                            --    S     0   H H   --   H    CH.sub.3                                                                           CH.sub.3                            J.sub.7                                                                            --    S     0   H H   --   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.7                                                                            --    S     1   H H   --   H    CH.sub.3                                                                           OCH.sub.2 CH.sub.3                  J.sub.7                                                                            --    S     1   H H   --   CH.sub.3                                                                           CH.sub.3                                                                           OCF.sub.2 H                         J.sub.8                                                                            --    S     0   H H   --   H    CH.sub.3                                                                           CH.sub.3                            J.sub.8                                                                            --    S     0   H H   --   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.8                                                                            --    S     1   H H   --   H    CH.sub.3                                                                           OCH.sub.2 CH.sub.3                  J.sub.8                                                                            --    S     1   H H   --   CH.sub.3                                                                           CH.sub.3                                                                           OCF.sub.2 H                         J.sub.9                                                                            O     S     --  H H   H    --   --   CH.sub.3                            J.sub.9                                                                            O     S     --  H H   CH.sub.3                                                                           --   --   OCH.sub.3                           J.sub.10                                                                           O     S     --  H H   H    --   --   OCH.sub.2 CH.sub.3                  J.sub.10                                                                           O     S     --  H H   CH.sub.3                                                                           --   --   OCF.sub.2 H                         J.sub.11                                                                           --    S     --  H H   --   H    CH.sub.3                                                                           CH.sub.3                            J.sub.11                                                                           --    S     --  H H   --   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.12                                                                           --    S     --  H --  --   H    CH.sub.3                                                                           OCH.sub.2 CH.sub.3                  J.sub.12                                                                           --    S     --  H --  --   CH.sub.3                                                                           CH.sub.3                                                                           OCF.sub.2 H                         J.sub.15                                                                           O     S     1   H H   CH.sub.3                                                                           H    --   OCH.sub.3                           J.sub.16                                                                           O     S     1   H H   CH.sub.3                                                                           H    --   OCH.sub.3                           J.sub.17                                                                           --    S     --  H H   --   H    --   OCH.sub.3                           J.sub.18                                                                           --    S     --  H H   --   H    --   OCH.sub.3                           J.sub.19                                                                           O     S     --  H H   CH.sub.3                                                                           H    --   OCH.sub.3                           J.sub.20                                                                           O     S     --  H H   CH.sub.3                                                                           H    --   OCH.sub.3                           J.sub.21                                                                           --    S     --  H H   --   H    --   OCH.sub.3                           J.sub.22                                                                           --    S     --  H H   --   H    --   OCH.sub.3                           ______________________________________                                    

                                      TABLE Va                                    __________________________________________________________________________    Structure Va                                                                                                        m.p.                                    J  W.sub.2                                                                          G Q    n R R.sub.1 (R.sub.1 ')                                                               R.sub.2                                                                          R.sub.3                                                                          X.sub.2                                                                            Y.sub.2                                                                             (°C.)                            __________________________________________________________________________    J.sub.1                                                                          -- S O    0 H H   H  H.sub.3                                                                          CH.sub.3                                                                           OCH                                           J.sub.1                                                                          -- S O    0 H H   H.sub.3                                                                          CH.sub.2                                                                         CH.sub.2 CH.sub.3                                                                  OCH CH                                        J.sub.1                                                                          -- S O    0 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                  SCH.sub.3                                     J.sub.1                                                                          -- S O    1 H H   H  H  CH.sub.3                                                                           SCH.sub.2 CH.sub.3                            J.sub.1                                                                          -- S O    1 H H   H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  CH.sub.3                                      J.sub.1                                                                          -- S O    1 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                  CH.sub.2 CH.sub.3                             J.sub.1                                                                          -- S S    0 H H   H  H  CH.sub.3                                                                           CH.sub.2 CH.sub.3                             J.sub.1                                                                          -- S S    0 H H   H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  CH.sub.3                                      J.sub.1                                                                          -- S S    0 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                  SCH.sub.2 CH.sub.3                            J.sub.1                                                                          -- S S    1 H H   H  H.sub.3                                                                          CH.sub.3                                                                           SCH                                           J.sub.1                                                                          -- S S    1 H H   H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  OCH.sub.2 CH.sub.3                            J.sub.1                                                                          -- S S    1 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                  OCH.sub.3                                     J.sub.1                                                                          -- S SO.sub.2                                                                           0 H H   H  H  CH.sub.3                                                                           OCH.sub.3                                     J.sub.1                                                                          -- S SO.sub.2                                                                           0 H H   H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  OCH.sub.2 CH.sub.3                            J.sub.1                                                                          -- S SO.sub.2                                                                           0 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                  SCH.sub.3                                     J.sub.1                                                                          -- S SO.sub.2                                                                           1 H H   H  H  CH.sub.3                                                                           SCH.sub.2 CH.sub.3                            J.sub.1                                                                          -- S SO.sub.2                                                                           1 H H   H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  CH.sub.3                                      J.sub.1                                                                          -- S SO.sub.2                                                                           1 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                  CH.sub.2 CH.sub. 3                            J.sub.2                                                                          -- S O    0 H H   H  H  CH.sub.3                                                                           CH.sub.2 CH.sub.3                             J.sub.2                                                                          -- S O    0 H H   H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  CH.sub.3                                      J.sub.2                                                                          -- S O    0 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                  SCH.sub.3                                     J.sub.2                                                                          -- S O    1 H H   H  H  CH.sub.3                                                                           SCH.sub.2 CH.sub.3                            J.sub.2                                                                          -- S O    1 H H   H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                     J.sub.2                                                                          -- S O    1 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                  OCH.sub.2 CH.sub.3                            J.sub.2                                                                          -- S S    0 H H   H  H  CH.sub.3                                                                           OCH.sub.3                                     J.sub.2                                                                          -- S S    0 H H   H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  OCH.sub.2 CH.sub.3                            J.sub.2                                                                          -- S S    0 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                  SCH.sub.3                                     J.sub.2                                                                          -- S S    1 H H   H  H  CH.sub.3                                                                           SCH.sub.2 CH.sub.3                            J.sub.2                                                                          -- S S    1 H H   H  CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                     J.sub.2                                                                          -- S S    1 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  OCH.sub.2 CH.sub.3                            J.sub.2                                                                          -- S SO.sub.2                                                                           0 H H   H  H  CH.sub.2 CF.sub.3                                                                  SCH.sub.3                                     J.sub.2                                                                          -- S SO.sub.2                                                                           0 H H   H  CH.sub.3                                                                         CH.sub.3                                                                           SCH.sub.2 CH.sub.3                            J.sub.2                                                                          -- S SO.sub.2                                                                           0 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  CH.sub.3                                      J.sub.2                                                                          -- S SO.sub.2                                                                           1 H H   H  H  CH.sub.2 CF.sub.3                                                                  CH.sub.2 CH.sub.3                             J.sub.2                                                                          -- S SO.sub.2                                                                           1 H H   H  CH.sub.3                                                                         CH.sub.3                                                                           CH.sub.2 CH.sub.3                             J.sub.2                                                                          -- S SO.sub.2                                                                           1 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  CH.sub.3                                      J.sub.3                                                                          O  S --   0 H H   H  H  CH.sub.2 CF.sub.3                                                                  SCH.sub.2 CH.sub.3                            J.sub.3                                                                          O  S --   0 H H   H  CH.sub.3                                                                         CH.sub.3                                                                           SCH.sub.3                                     J.sub.3                                                                          O  S --   0 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  OCH.sub.2 CH.sub.3                            J.sub.3                                                                          O  S --   1 H H   H  H  CH.sub.2 CF.sub.3                                                                  OCH.sub.3                                     J.sub.3                                                                          O  S --   1 H H   H  CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                     J.sub.3                                                                          O  S --   1 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  OCH.sub.2 CH.sub.3                            J.sub.4                                                                          O  S --   0 H H   H  H  CH.sub.2 CF.sub.3                                                                  SCH.sub.3                                     J.sub.4                                                                          O  S --   0 H H   H  CH.sub.3                                                                         CH.sub.3                                                                           SCH.sub.2 CH.sub.3                            J.sub.4                                                                          O  S --   0 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  CH.sub.3                                      J.sub.4                                                                          O  S --   1 H H   H  H  CH.sub.2 CF.sub.3                                                                  CH.sub.2 CH.sub.3                             J.sub.4                                                                          O  S --   1 H H   H  CH.sub.3                                                                         CH.sub.3                                                                           CH.sub.2 CH.sub.3                             J.sub.4                                                                          O  S --   1 H H   CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                  CH.sub.3                                      J.sub.1                                                                          -- S CH.sub.2                                                                           0 H H   H  H  CH.sub.2 CF.sub.3                                                                  SCH.sub.3                                     J.sub.1                                                                          -- S CH.sub.2                                                                           0 H H   H  CH.sub.3                                                                         CH.sub.3                                                                           SCH.sub.2 CH.sub.3                            J.sub.1                                                                          -- S CHCH.sub.3                                                                         0 H H   H  H  CH.sub.2 CH.sub.3                                                                  OCH.sub.3                                     J.sub.1                                                                          -- S CH.sub.2                                                                           1 H H   H  H  CH.sub.2 CF.sub.3                                                                  OCH.sub.2 CH.sub.3                            J.sub.1                                                                          -- S CH.sub.2                                                                           1 H H   H  CH.sub.3                                                                         CH.sub.3                                                                           OCH.sub.3                                     J.sub.1                                                                          -- S CHCH.sub.3                                                                         1 H H   H  H  CH.sub.2 CH.sub.3                                                                  OCH.sub.2 CH.sub.3                            J.sub.13                                                                         -- S --   --                                                                              H H   H  -- CH.sub.2 CF.sub.3                                                                  SCH.sub.3                                     J.sub.13                                                                         -- S --   --                                                                              H H   Cl -- CH.sub.2 CF.sub.3                                                                  SCH.sub.3                                     J.sub.14                                                                         -- S --   --                                                                              H H   H  -- CH.sub.3                                                                           SCH.sub.2 CH.sub.3                            J.sub.14                                                                         -- S --   --                                                                              H H   Cl -- CH.sub.3                                                                           SCH.sub.2 CH.sub.3                            __________________________________________________________________________

                                      TABLE Vb                                    __________________________________________________________________________    Structure Vb                                                                                                       m.p.                                     J  W.sub.2                                                                          G n R R.sub.1 (R.sub.1 ')                                                               R.sub.4                                                                          R.sub.5                                                                          R.sub.6                                                                          X.sub.2                                                                             Y.sub.2                                                                             (°C.)                             __________________________________________________________________________    J.sub.5                                                                          O  S 0 H H   H  H  -- CH.sub.3                                                                            OCH.sub.3                                      J.sub.5                                                                          O  S 0 H H   H  CH.sub.3                                                                         -- CH.sub.2 OCH.sub.3                                                                  OCH.sub.2 CH.sub.3                             J.sub.5                                                                          O  S 0 H H   H  CH.sub.3                                                                         -- CH.sub.2 CF.sub.3                                                                   SCH.sub.3                                      J.sub.5                                                                          O  S 1 H H   H  H  -- CH.sub.3                                                                            SCH.sub.2 CH.sub.3                             J.sub.5                                                                          O  S 1 H H   CH.sub.3                                                                         H  -- CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                      J.sub.5                                                                          O  S 1 H H   CH.sub.3                                                                         CH.sub.3                                                                         -- OCH.sub.2 CF.sub.3                                                                  CH.sub.2 CH.sub.3                              J.sub.6                                                                          O  S 0 H H   H  H  -- CH.sub.3                                                                            OCH.sub.2 CH.sub.3                             J.sub.6                                                                          O  S 0 H H   H  CH.sub.3                                                                         -- CH.sub.2 CH.sub.3                                                                   CH.sub.3                                       J.sub.6                                                                          O  S 0 H H   H  CH.sub.3                                                                         -- CH.sub.2 CF.sub.3                                                                   SCH.sub.2 CH.sub.3                             J.sub.6                                                                          O  S 1 H H   H  H  -- CH.sub.3                                                                            SCH.sub.3                                      J.sub.6                                                                          O  S 1 H H   CH.sub.3                                                                         H  -- CH.sub.2 CH.sub.3                                                                   OCH.sub.2 CH.sub.3                             J.sub.6                                                                          O  S 1 H H   CH.sub.3                                                                         CH.sub.3                                                                         -- CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                      J.sub.7                                                                          -- S 0 H H   -- H  CH.sub.3                                                                         CH.sub.3                                                                            OCH.sub.3                                      J.sub.7                                                                          -- S 0 H H   -- CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                   OCH.sub.2 CH.sub.3                             J.sub.7                                                                          -- S 1 H H   -- H  CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                   SCH.sub.3                                      J.sub.7                                                                          -- S 1 H H   -- CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                            SCH.sub.2 CH.sub.3                             J.sub.8                                                                          -- S 0 H H   -- H  CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                   CH.sub.3                                       J.sub.8                                                                          -- S 0 H H   -- CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                   CH.sub.2 CH.sub.3                              J.sub.8                                                                          -- S 1 H H   -- H  CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2 CH.sub.3                              J.sub.8                                                                          -- S 1 H H   -- CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                   CH.sub.3                                       J.sub.9                                                                          O  S --                                                                              H H   H  -- -- CH.sub.2 CF.sub.3                                                                   SCH.sub.3                                      J.sub.9                                                                          O  S --                                                                              H H   CH.sub.3                                                                         -- -- CH.sub.3                                                                            SCH.sub.2 CH.sub.3                             J.sub.10                                                                         O  S --                                                                              H H   H  -- -- CH.sub.2 CH.sub.3                                                                   OCH.sub.3                                      J.sub.10                                                                         O  S --                                                                              H H   CH.sub.3                                                                         -- -- CH.sub.2 CF.sub.3                                                                   OCH.sub.3                                      J.sub.11                                                                         -- S --                                                                              H H   -- H  CH.sub.3                                                                         CH.sub.3                                                                            OCH.sub.3                                      J.sub.11                                                                         -- S --                                                                              H H   -- CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                   OCH.sub.2 CH.sub.3                             J.sub.12                                                                         -- S --                                                                              H H   -- H  CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                   SCH.sub.3                                      J.sub.12                                                                         -- S --                                                                              H H   -- CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                            SCH.sub. 2 CH.sub.3                            J.sub.15                                                                         O  S 1 H H   CH.sub.3                                                                         H  -- CH.sub.3                                                                            OCH.sub.3                                      J.sub.16                                                                         O  S 1 H H   CH.sub.3                                                                         H  -- CH.sub.3                                                                            OCH.sub.3                                      J.sub.17                                                                         -- S --                                                                              H H   -- H  -- CH.sub.3                                                                            OCH.sub.3                                      J.sub.18                                                                         -- S --                                                                              H H   -- H  -- CH.sub.3                                                                            OCH.sub.3                                      J.sub.19                                                                         O  S --                                                                              H H   CH.sub.3                                                                         H  -- CH.sub.3                                                                            OCH.sub.3                                      J.sub.20                                                                         O  S --                                                                              H H   CH.sub.3                                                                         H  -- CH.sub.3                                                                            OCH.sub.3                                      J.sub.21                                                                         -- S --                                                                              H H   -- H  -- CH.sub.3                                                                            OCH.sub.3                                      J.sub.22                                                                         -- S --                                                                              H H   -- H  -- CH.sub.3                                                                            OCH.sub.3                                      __________________________________________________________________________

                  TABLE VIa                                                       ______________________________________                                        Structure VIa                                                                                           R.sub.1               m.p.                          J    W.sub.2                                                                              G Q       n   R (R.sub.1 ')                                                                       R.sub.2                                                                            R.sub.3                                                                            X.sub.3                                                                             (°C.)                  ______________________________________                                        J.sub.1                                                                            --     SO        0   H H   H    H    CH.sub.3                            J.sub.1                                                                            --     SO        0   H H   H    CH.sub.3                                                                           OCH.sub.3                           J.sub.1                                                                            --     SO        0   H H   CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                            J.sub.1                                                                            --     SO        1   H H   H    H    OCH.sub.3                           J.sub.1                                                                            --     SO        1   H H   H    CH.sub.3                                                                           CH.sub.3                            J.sub.1                                                                            --     SO        1   H H   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.1                                                                            --     SS        0   H H   H    H    CH.sub.3                            J.sub.1                                                                            --     SS        0   H H   H    CH.sub.3                                                                           OCH.sub.3                           J.sub.1                                                                            --     SS        0   H H   CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                            J.sub.1                                                                            --     SS        1   H H   H    H    OCH.sub.3                           J.sub.1                                                                            --     SS        1   H H   H    CH.sub.3                                                                           CH.sub.3                            J.sub.1                                                                            --     SS        1   H H   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.1                                                                            --     SSO.sub.2 0   H H   H    H    CH.sub.3                            J.sub.1                                                                            --     SSO.sub.2 0   H H   H    CH.sub.3                                                                           OCH.sub.3                           J.sub.1                                                                            --     SSO.sub.2 0   H H   CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                            J.sub.1                                                                            --     SSO.sub.2 1   H H   H    H    OCH.sub.3                           J.sub.1                                                                            --     SSO.sub.2 1   H H   H    CH.sub.3                                                                           CH.sub.3                            J.sub.1                                                                            --     SSO.sub.2 1   H H   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.2                                                                            --     SO        0   H H   H    H    CH.sub.3                            J.sub.2                                                                            --     SO        0   H H   H    CH.sub.3                                                                           OCH.sub.3                           J.sub.2                                                                            --     SO        0   H H   CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                            J.sub.2                                                                            --     SO        1   H H   H    H    OCH.sub.3                           J.sub.2                                                                            --     SO        1   H H   H    CH.sub.3                                                                           CH.sub.3                            J.sub.2                                                                            --     SO        1   H H   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.2                                                                            --     SS        0   H H   H    H    CH.sub.3                            J.sub.2                                                                            --     SS        0   H H   H    CH.sub.3                                                                           OCH.sub.3                           J.sub.2                                                                            --     SS        0   H H   CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                            J.sub.2                                                                            --     SS        1   H H   H    H    OCH.sub.3                           J.sub.2                                                                            --     SS        1   H H   H    CH.sub.3                                                                           CH.sub.3                            J.sub.2                                                                            --     SS        1   H H   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.2                                                                            --     SSO.sub.2 0   H H   H    H    CH.sub.3                            J.sub.2                                                                            --     SSO.sub.2 0   H H   H    CH.sub.3                                                                           OCH.sub.3                           J.sub.2                                                                            --     SSO.sub.2 0   H H   CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                            J.sub.2                                                                            --     SSO.sub.2 1   H H   H    H    OCH.sub.3                           J.sub.2                                                                            --     SSO.sub.2 1   H H   H    CH.sub.3                                                                           CH.sub.3                            J.sub.2                                                                            --     SSO.sub.2 1   H H   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.3                                                                            O      S--       0   H H   H    H    CH.sub.3                            J.sub.3                                                                            O      S--       0   H H   H    CH.sub.3                                                                           OCH.sub.3                           J.sub.3                                                                            O      S--       0   H H   CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                            J.sub.3                                                                            O      S--       1   H H   H    H    OCH.sub.3                           J.sub.3                                                                            O      S--       1   H H   H    CH.sub.3                                                                           CH.sub.3                            J.sub.3                                                                            O      S--       1   H H   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.4                                                                            O      S--       0   H H   H    H    CH.sub.3                            J.sub.4                                                                            O      S--       0   H H   H    CH.sub.3                                                                           OCH.sub.3                           J.sub.4                                                                            O      S--       0   H H   CH.sub.3                                                                           CH.sub.3                                                                           CH.sub.3                            J.sub.4                                                                            O      S--       1   H H   H    H    OCH.sub.3                           J.sub.4                                                                            O      S--       1   H H   H    CH.sub.3                                                                           CH.sub.3                            J.sub.4                                                                            O      S--       1   H H   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                           J.sub.1                                                                            --     SCH.sub.2 0   H H   H    H    CH.sub.3                            J.sub.1                                                                            --     SCH.sub.2 0   H H   H    CH.sub.3                                                                           OCH.sub.3                           J.sub.1                                                                            --     SCHCH.sub.3                                                                             0   H H   H    H    CH.sub.3                            J.sub.1                                                                            --     SCH.sub.2 1   H H   H    H    OCH.sub.3                           J.sub.1                                                                            --     SCH.sub.2 1   H H   H    CH.sub.3                                                                           CH.sub.3                            J.sub.1                                                                            --     SCHCH.sub.3                                                                             1   H H   H    H    OCH.sub.3                           J.sub.13                                                                           --     S--       --  H H   H    --   CH.sub.3                            J.sub.13                                                                           --     S--       --  H H   Cl   --   OCH.sub.3                           J.sub.14                                                                           --     S--       --  H H   H    --   CH.sub.3                            J.sub.14                                                                           --     S--       --  H H   Cl   --   OCH.sub.3                           ______________________________________                                    

                  TABLE VIb                                                       ______________________________________                                        Structure VIb                                                                                                                   m.p.                        J    W.sub.2                                                                              G n    R   R.sub.1 (R.sub.1 ')                                                                 R.sub.4                                                                            R.sub.5                                                                            R.sub.6                                                                            X.sub.3                                                                             (°C.)                ______________________________________                                        J.sub.5                                                                            O      S0     H   H     H    H    --   CH.sub.3                          J.sub.5                                                                            O      S0     H   H     H    CH.sub.3                                                                           --   OCH.sub.3                         J.sub.5                                                                            O      S0     H   H     H    CH.sub.3                                                                           --   CH.sub.3                          J.sub.5                                                                            O      S1     H   H     H    H    --   OCH.sub.3                         J.sub.5                                                                            O      S1     H   H     CH.sub.3                                                                           H    --   CH.sub.3                          J.sub.5                                                                            O      S1     H   H     CH.sub.3                                                                           CH.sub.3                                                                           --   OCH.sub.3                         J.sub.6                                                                            O      S0     H   H     H    H    --   CH.sub.3                          J.sub.6                                                                            O      S0     H   H     H    CH.sub.3                                                                           --   OCH.sub.3                         J.sub.6                                                                            O      S0     H   H     H    CH.sub.3                                                                           --   CH.sub.3                          J.sub.6                                                                            O      S1     H   H     H    H    --   OCH.sub.3                         J.sub.6                                                                            O      S 1    H   H     CH.sub.3                                                                           H    --   CH.sub.3                          J.sub.6                                                                            O      S1     H   H     CH.sub.3                                                                           CH.sub.3                                                                           --   OCH.sub.3                         J.sub.7                                                                            --     S0     H   H     --   H    CH.sub.3                                                                           CH.sub.3                          J.sub.7                                                                            --     S0     H   H     --   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                         J.sub.7                                                                            --     S1     H   H     --   H    CH.sub.3                                                                           CH.sub.3                          J.sub.7                                                                            --     S1     H   H     --   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                         J.sub.8                                                                            --     S0     H   H     --   H    CH.sub.3                                                                           CH.sub.3                          J.sub.8                                                                            --     S0     H   H     --   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                         J.sub.8                                                                            --     S1     H   H     --   H    CH.sub.3                                                                           CH.sub.3                          J.sub.8                                                                            --     S1     H   H     --   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                         J.sub.9                                                                            O      S--    H   H     H    --   --   CH.sub.3                          J.sub.9                                                                            O      S--    H   H     CH.sub.3                                                                           --   --   OCH.sub.3                         J.sub.10                                                                           O      S--    H   H     H    --   --   CH.sub.3                          J.sub.10                                                                           O      S--    H   H     CH.sub.3                                                                           --   --   OCH.sub.3                         J.sub.11                                                                           --     S--    H   H     --   H    CH.sub.3                                                                           CH.sub.3                          J.sub.11                                                                           --     S--    H   H     --   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                         J.sub.12                                                                           --     S--    H   --    --   H    CH.sub.3                                                                           CH.sub.3                          J.sub.12                                                                           --     S--    H   --    --   CH.sub.3                                                                           CH.sub.3                                                                           OCH.sub.3                         J.sub.15                                                                           O      S1     H   H     CH.sub.3                                                                           H    --   OCH.sub.3                         J.sub.16                                                                           O      S1     H   H     CH.sub.3                                                                           H    --   OCH.sub.3                         J.sub.17                                                                           --     S--    H   H     --   H    --   OCH.sub.3                         J.sub.18                                                                           --     S--    H   H     --   H    --   OCH.sub.3                         J.sub.19                                                                           O      S--    H   H     CH.sub.3                                                                           H    --   OCH.sub.3                         J.sub.20                                                                           O      S--    H   H     CH.sub.3                                                                           H    --   OCH.sub.3                         J.sub.21                                                                           --     S--    H   H     --   H    --   OCH.sub.3                         J.sub.22                                                                           --     S--    H   H     --   H    --   OCH.sub. 3                        ______________________________________                                    

                                      TABLE VIIa                                  __________________________________________________________________________    Structure VIIa                                                                                                       m.p.                                   J  W.sub.2                                                                          G Q  n R R.sub.1 (R.sub.1 ')                                                               R.sub.2                                                                          R.sub.3                                                                         X.sub.4                                                                             Y.sub.4                                                                             Z.sub.1                                                                          (°C.)                           __________________________________________________________________________    J-1                                                                              -- S SO.sub.2                                                                         0 H H   CH.sub.3                                                                         H CH.sub.3                                                                            CH.sub.3                                                                            N                                         J-2                                                                              -- S SO.sub.2                                                                         1 H H   H  CH.sub.3                                                                        CH.sub.3                                                                            CH.sub.3                                                                            N                                         J-3                                                                              O  S -- 1 H H   H  H CH.sub.3                                                                            CH.sub.3                                                                            N                                         J-4                                                                              O  S -- 1 H H   H  H CH.sub.3                                                                            CH.sub.3                                                                            N                                         J-13                                                                             -- S -- --                                                                              H H   H  --                                                                              CH.sub.3                                                                            CH.sub.3                                                                            N                                         J-14                                                                             -- S -- --                                                                              H H   H  --                                                                              CH.sub.3                                                                            CH.sub.3                                                                            N                                         J-1                                                                              -- S SO.sub.2                                                                         0 H H   CH.sub.3                                                                         H CH.sub.3                                                                            CH.sub.3                                                                            CH                                        J-1                                                                              -- S SO.sub.2                                                                         0 H H   CH.sub.3                                                                         H CH.sub.3                                                                            OCH.sub.3                                                                           N                                         J-1                                                                              -- S SO.sub.2                                                                         0 H H   CH.sub.3                                                                         H CH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                  N                                         J-1                                                                              -- S SO.sub.2                                                                         0 H H   CH.sub.3                                                                         H Cl    OCH.sub.3                                                                           CH                                        J-1                                                                              -- S SO.sub.2                                                                         0 H H   CH.sub.3                                                                         H CH.sub.2 OCH.sub.3                                                                  CH.sub.3                                                                            N                                         J-1                                                                              -- S SO.sub.2                                                                         0 H H   CH.sub.3                                                                         H OCH.sub.2 CH.sub.3                                                                  CH.sub.3                                                                            N                                         __________________________________________________________________________

                                      TABLE VIIb                                  __________________________________________________________________________    Structure VIIb                                                                J  W.sub.2                                                                          G n R R.sub.1 (R.sub.1 ')                                                               R.sub.4                                                                          R.sub.5                                                                          R.sub.6                                                                          X.sub.4                                                                          Y.sub.4                                                                          Z.sub.1                                                                         m.p. (°C.)                            __________________________________________________________________________    J-5                                                                              O  S 1 H H   H  H  -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-6                                                                              O  S 1 H H   H  H  -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-7                                                                              -- S 0 H H   -- H  CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-8                                                                              -- S 0 H H   -- H  CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-9                                                                              O  S --                                                                              H H   H  -- -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-10                                                                             O  S --                                                                              H H   H  -- -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-11                                                                             -- S --                                                                              H H   -- H  CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-12                                                                             -- S --                                                                              H H   -- H  CH.sub.3                                                                         CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-15                                                                             O  S 1 H H   CH.sub.3                                                                         H  -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-16                                                                             O  S 1 H H   CH.sub.3                                                                         H  -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-18                                                                             -- S --                                                                              H H   -- H  -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-19                                                                             O  S --                                                                              H H   CH.sub.3                                                                         H  -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-20                                                                             O  S --                                                                              H H   CH.sub.3                                                                         H  -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-21                                                                             -- S --                                                                              H H   -- H  -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              J-22                                                                             -- S --                                                                              H H   -- H  -- CH.sub.3                                                                         CH.sub.3                                                                         N                                              __________________________________________________________________________

                  TABLE VIII                                                      ______________________________________                                        Structures A, B, C, D, E, and F                                                                  R.sub.1                                                    J    G       n     (R.sub.1 ')                                                                        R.sub.4                                                                            R.sub.5                                                                           R.sub.17                                                                              R.sub.18                                                                             R.sub.33                      ______________________________________                                        23   S       0     H    --   --  H       OH     --                            23   S       1     H    --   --  H       OH     --                            23   S       0     H    --   --  CO.sub.2 CH.sub.3                                                                     H      --                            23   S       1     H    --   --  OCH.sub.3                                                                             OCH.sub.3                                                                            --                            23   S       1     H    --   --  --OCH.sub.2 CH.sub.2 O--                                                                   --                              23   S       1     H    --   --  --OCH.sub.2 CH.sub.2 CH.sub.2 O--                                                          --                              24   S       1     H    --   --  H       OH     --                            45   S       0     H    --   --  H       H      --                            45   S       1     H    --   --  H       H      --                            46   S       0     H    --   --  H       H      --                            47   S       0     H    --   --  H       H      --                            48   S       0     H    --   --  H       H      --                            49   S       1     H    H    --  H       H      --                            50   S       1     H    CH.sub.3                                                                           --  H       H      --                            63   S       --    H    --   --  H       H      --                            64   S       --    H    --   --  H       H      --                            65   S       --    H    --   --  H       H      --                            66   S       --    H    --   --  H       H      --                            67   S       --    H    --   H   H       H      --                            68   S       --    H    --   H   H       H      --                            75   S       --    H    --   --  H       H      --                            76   S       --    H    --   --  H       H      --                            161  S       --    H    --   --  H       --     H                             162  S       --    H    --   --  CH.sub.3                                                                              --     CH.sub.3                      163  S       --    H    --   --  CH.sub.3                                                                              CH.sub.3                                                                             H                             164  S       --    H    --   --  H       H      CH.sub.3                      23   O       1     H    --   --  H       OH     --                            23   NH      1     H    --   --  H       OH     --                            23   NCH.sub.3                                                                             1     H    --   --  H       OH     --                            ______________________________________                                    

                  TABLE IX                                                        ______________________________________                                        Structures A, B, C, D, E, and F                                               J     G        n      R.sub.1 (R.sub.1 ')                                                                  R.sub.4                                                                            R.sub.9                                                                            R.sub.19                                                                            R.sub.20                         ______________________________________                                        25    S        0      H      H    H    H     --                               25    S        1      H      H    H    H     --                               26    S        1      H      H    H    H     --                               77    S        --     H      --   H    H     --                               77    O        --     H      --   H    H     --                               77    NH       --     H      --   H    H     --                               77    NCH.sub.3                                                                              --     H      --   H    H     --                               78    S        --     H      --   H    H     --                               79    S        --     H      --   --   --    CH.sub.3                         79    O        --     H      --   --   --    CH.sub.3                         79    NH       --     H      --   --   --    CH.sub.3                         79    NCH.sub.3                                                                              --     H      --   --   --    CH.sub.3                         80    S        --     H      --   --   --    CH.sub.3                         ______________________________________                                    

                  TABLE X                                                         ______________________________________                                        Structures A, B, C, D, E, and F                                               J    G      n      R.sub.1 (R.sub.1 ')                                                                 R.sub.4                                                                            R.sub.21                                                                           R.sub.22                                                                           R.sub.24                                                                           R.sub.25                                                                           q                           ______________________________________                                        35   S      0      H     --   H    H    --   --   --                          36   S      0      H     --   H    H    --   --   --                          37   S      0      H     --   H    H    --   --   --                          38   S      0      H     --   H    H    --   --   --                          39   S      0      H     CH.sub.3                                                                           H    H    --   --   --                          40   S      0      H     CH.sub.3                                                                           H    H    --   --   --                          105  S      --     H     --   --   --   H    --   0                           105  S      --     H     --   --   --   H    --   1                           106  S      --     H     --   --   --   CH.sub.3                                                                           --   0                           107  S      --     H     --   --   --   H    --   0                           108  S      --     H     --   --   --   H    --   0                           109  S      --     H     --   --   --   H    H    --                          110  S      --     H     --   --   --   H    H    --                          111  S      --     H     --   --   --   H    H    --                          112  S      --     H     --   --   --   H    H    --                          113  S      --     H     --   --   --   --   --   --                          114  S      --     H     --   --   --   --   --   --                          115  S      --     H     --   --   --   CH.sub.3                                                                           --   --                          116  S      --     H     --   --   --   CH.sub.3                                                                           --   --                          117  S      --     H     --   --   --   H    --   --                          118  S      --     H     --   --   --   H    --   --                          119  S      --     H     --   --   --   H    --   --                          120  S      --     H     --   --   --   H    --   --                          121  S      --     H     --   --   --   H    H    --                          122  S      --     H     --   --   --   H    H    --                          ______________________________________                                    

                  TABLE XI                                                        ______________________________________                                        Structures A, B, C, D, E, and F                                               J      G        n      R.sub.1 (R.sub.1 ')                                                                  R.sub.2                                                                            R.sub.3                                                                            R.sub.4                                                                             R.sub.5                         ______________________________________                                        51     S        0      CH.sub.3                                                                             H    H    --    --                              51     S        1      CH.sub.3                                                                             H    H    --    --                              52     S        1      H      H    H    --    --                              53     S        0      CH.sub.3                                                                             H    H    --    --                              53     S        1      CH.sub.3                                                                             H    H    --    --                              54     S        1      H      H    H    --    --                              55     S        0      CH.sub.3                                                                             H    H    CH.sub.3                                                                            --                              56     S        0      H      H    H    CH.sub.3                                                                            --                              57     S        1      CH.sub.3                                                                             H    H    --    --                              58     S        1      H      H    H    --    --                              59     S        1      CH.sub.3                                                                             H    H    --    --                              60     S        1      H      H    H    --    --                              61     S        1      CH.sub.3                                                                             H    H    CH.sub.3                                                                            --                              62     S        1      H      H    H    CH.sub.3                                                                            --                              69     S        --     CH.sub. 3                                                                            H    H    --    --                              69     O        --     CH.sub.3                                                                             H    H    --    --                              69     NH       --     CH.sub.3                                                                             H    H    --    --                              69     NCH.sub.3                                                                              --     CH.sub.3                                                                             H    H    --    --                              70     S        --     H      H    H    --    --                              71     S        --     CH.sub.3                                                                             H    H    --    --                              72     S        --     H      H    H    --    --                              73     S        --     CH.sub.3                                                                             H    H    --    H                               74     S        --     H      H    H    --    H                               99     S        --     CH.sub.3                                                                             H    H    --    --                              100    S        --     H      H    H    --    --                              101    S        --     CH.sub.3                                                                             H    H    --    --                              102    S        --     H      H    H    --    --                              103    S        --     CH.sub.3                                                                             H    H    --    H                               104    S        --     H      H    H    --    H                               51     O        1      CH.sub.3                                                                             H    H    --    --                              51     NCH.sub.3                                                                              1      CH.sub.3                                                                             H    H    --    --                              ______________________________________                                    

                  TABLE XII                                                       ______________________________________                                        Structures A, B, C, D, E, and F                                               J   G      n      R.sub.1 (R.sub.1 ')                                                                  R.sub.4                                                                             R.sub.5                                                                             R.sub.9                                                                             W.sub.2                                                                             P                            ______________________________________                                        27  S      1      H      H     --    --    --    --                           28  S      1      H      H     --    --    --    --                           29  S      1      H      H     --    --    --    --                           30  S      1      H      H     --    --    --    --                           31  S      1      H      H     --    CH.sub.3                                                                            --    --                           32  S      1      H      H     --    CH.sub.3                                                                            --    --                           33  S      1      H      --    H     CH.sub.3                                                                            --    --                           34  S      1      H      --    H     CH.sub.3                                                                            --    --                           41  S      1      H      H     H     --    O     --                           41  S      1      H      H     H     --    S     --                           42  S      1      H      H     H     --    O     --                           43  S      1      H      H     H     --    --    --                           44  S      1      H      H     H     --    --    --                           81  S      --     H      CH.sub.3                                                                            CH.sub.3                                                                            --    --    --                           82  S      --     H      CH.sub.3                                                                            CH.sub.3                                                                            --    --    --                           83  S      --     H      CH.sub.3                                                                            CH.sub.3                                                                            --    --    0                            83  S      --     H      H     H     --    --    2                            84  S      --     H      CH.sub.3                                                                            CH.sub.3                                                                            --    --    2                            85  S      --     H      CH.sub.3                                                                            CH.sub.3                                                                            H     --    --                           86  S      --     H      CH.sub.3                                                                            CH.sub.3                                                                            H     --    --                           87  S      --     H      H     --    --    --    --                           88  S      --     H      H     --    --    --    --                           89  S      --     H      H     --    --    --    --                           90  S      --     H      H     --    --    --    --                           91  S      --     H      H     --    CH.sub.3                                                                            --    --                           92  S      --     H      H     --    CH.sub.3                                                                            --    --                           93  S      --     H      --    H     CH.sub.3                                                                            --    --                           94  S      --     H      --    H     CH.sub.3                                                                            --    --                           95  S      --     H      H     --    --    --    --                           96  S      --     H      H     --    --    --    --                           97  S      --     H      H     --    --    --    --                           98  S      --     H      H     --    --    --    --                           ______________________________________                                    

                  TABLE XIII                                                      ______________________________________                                        Structures A, B, C, D, E, and F                                               J       G      n      R.sub.1 (R.sub.1 ')                                                                  R.sub.26                                                                            R.sub.27                                                                            Q.sub.1                              ______________________________________                                        123     S      --     H      H     H     O                                    123     S      --     H      H     H     S                                    123     S      --     H      H     H     CH.sub.3                             123     S      --     H      H     H     NCH.sub.3                            124     S      --     H      H     H     CH.sub.2                             125     S      --     H      CH.sub.3                                                                            --    --                                   126     S      --     H      CH.sub.3                                                                            --    --                                   127     S      --     H      CH.sub.3                                                                            --    --                                   165     S      --     H      H     H     O                                    165     S      --     H      H     H     S                                    165     S      --     H      H     H     CH.sub.2                             165     S      --     H      H     H     NCH.sub.3                            166     S      --     H      H     H     CH.sub.2                             ______________________________________                                    

                  TABLE XIV                                                       ______________________________________                                        Structures A, B, C, D, E, and F                                               J    G       R.sub.1 (R.sub.1 ')                                                                   R.sub.4                                                                            R.sub.5                                                                            R.sub.28                                                                            R.sub.29                                                                           R.sub.30                                                                           R.sub.31                       ______________________________________                                        127  S       CH.sub.3                                                                              --   --   CH.sub.3                                                                            CH.sub.3                                                                           --   --                             127  O       H       --   --   H     H    --   --                             128  S       H       --   --   H     H    --   --                             129  S       H       H    --   CH.sub.3                                                                            CH.sub.3                                                                           --   --                             129  NH      H       H    --   H     H    --   --                             129  NCH.sub.3                                                                             H       CH.sub.3                                                                           --   H     H    --   --                             130  S       H       CH.sub.3                                                                           --   H     H    --   --                             131  O       CH.sub.3                                                                              --   --   --    H    CH.sub.3                                                                           --                             132  S       H       --   --   --    CH.sub.3                                                                           CH.sub.3                                                                           --                             133  S       CH.sub.3                                                                              --   --   --    H    CH.sub.3                                                                           --                             134  S       H       --   --   --    CH.sub.3                                                                           CH.sub.3                                                                           --                             135  NH      H       --   H    --    H    H    --                             135  NCH.sub.3                                                                             H       --   CH.sub.3                                                                           --    H    H    --                             136  S       H       --   H    --    CH.sub.3                                                                           CH.sub.3                                                                           --                             137  S       CH.sub.3                                                                              --   --   --    --   --   H                              138  S       H       --   --   --    --   --   H                              139  S       CH.sub.3                                                                              --   --   --    --   --   H                              140  S       H       --   --   --    --   --   H                              141  S       CH.sub.3                                                                              CH.sub.3                                                                           --   --    --   --   H                              142  S       H       CH.sub.3                                                                           --   --    --   --   H                              ______________________________________                                    

                  TABLE XV                                                        ______________________________________                                        Structures A, B, C, D, E, and F                                               J       G      R.sub.1 (R.sub.1 ')                                                                    R.sub.4                                                                              R.sub.5                                                                            R.sub.32                                                                            R.sub.33                            ______________________________________                                        143     S      CH.sub.3 --     --   CH.sub.3                                                                            --                                  144     S      H        --     --   CH.sub.3                                                                            --                                  145     S      CH.sub.3 --     --   CH.sub.3                                                                            --                                  146     S      H        --     --   CH.sub.3                                  147     S      CH.sub.3 CH.sub.3                                                                             --   --    CH.sub.3                            148     S      H        CH.sub.3                                                                             --   --    CH.sub.3                            149     S      CH.sub.3 --     --   --    CH.sub.3                            150     S      H        --     --   --    CH.sub.3                            151     S      CH.sub.3 --     --   --    CH.sub.3                            152     S      H        --     --   --    CH.sub.3                            153     S      CH.sub.3 --     H    CH.sub.3                                                                            --                                  154     S      H        --     H    CH.sub.3                                                                            --                                  155     S      CH.sub.3 --     --   --    CH.sub.3                            156     S      H        --     --   --    CH.sub. 3                           157     S      CH.sub.3 --     --   --    CH.sub.3                            158     S      H        --     --   --    CH.sub.3                            159     S      CH.sub.3 --     H    --    CH.sub.3                            160     S      H        --     H    --    CH.sub.3                            ______________________________________                                    

FORMULATIONS

Useful formulations of the compounds of Formula I can be prepared inconventional ways. They include dusts, granules, pellets, solutions,suspensions, emulsions, wettable powders, emulsifiable concentrates andthe like. Many of these may be applied directly. Sprayable formulationscan be extended in suitable media and used at spray volumes of from afew liters to several hundred liters per hectare. High strengthcompositions are primarily used as intermediates for furtherformulation. The formulations, broadly, contain about 0.1% to 99% byweight of active ingredient(s) and at least one of (a) about 0.1% to 20%surfactant(s) and (b) about 1% to 99.9% solid or liquid inertdiluent(s). More specifically, they will contain these ingredients inthe following approximate proportions:

                  TABLE XVI                                                       ______________________________________                                                    Active  Weight Percent*                                                       Ingredient                                                                            Diluent(s)                                                                              Surfactant(s)                                   ______________________________________                                        Wettable Powders                                                                            20-90      0-74     1-10                                        Oil Suspensions,                                                                             3-50     40-95     0-15                                        Emulsions, Solutions,                                                         (including Emulsifiable                                                       Concentrates)                                                                 Aqueous Suspension                                                                          10-50     40-84     1-20                                        Dusts          1-25     70-99     0-5                                         Granules and Pellets                                                                        0.1-95      5-99.9  0-15                                        High Strength 90-99      0-10     0-2                                         Compositions                                                                  ______________________________________                                         *Active ingredient plus at least one of a Surfactant or a Diluent equals      100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be presentdepending on the intended use and the physical properties of thecompound. Higher ratios of surfactant to active ingredient are sometimesdesirable, and are achieved by incorporation into the formulation or bytank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook ofInsecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books,Caldwell, N.J., but other solids, either mined or manufactured, may beused. The more absorptive diluents are preferred for wettable powdersand the denser ones for dusts. Typical liquid diluents and solvents aredescribed in Marsden, "Solvents Guide," 2nd Ed., Interscience, New York,1950. Solubility under 0.1% is preferred for suspension concentrates;solution concentrates are preferably stable against phase separation at0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC PublishingCorp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia ofSurface Active Agents", Chemical Publishing Co., Inc., New York, 1964,list surfactants and recommended uses. All formulations can containminor amounts of additives to reduce foaming, caking, corrosion,microbiological growth, etc.

The methods of making such compositions are well known. Solutions areprepared by simply mixing the ingredients. Fine solid compositions aremade by blending and, usually, grinding as in a hammer or fluid energymill. Suspensions are prepared by wet milling (see, for example,Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made byspraying the active material upon preformed granular carriers or byagglomeration techniques. See J. E. Browning, "Agglomeration", ChemicalEngineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer'sHandbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-57ff.

In the following examples, all parts are by weight unless otherwiseindicated.

EXAMPLE 12 Wettable Powder

    ______________________________________                                        N--[(4-methoxy-6-methylpyrimidin-2-yl)amino-                                                            80%                                                 carbonyl]-6,7-dihydro-5H--thieno[3,2-B]thio-                                  pyran-3-sulfonamide, 4,4-dioxide                                              sodium alkylnaphthalenesulfonate                                                                        2%                                                  sodium ligninsulfonate    2%                                                  synthetic amorphous silica                                                                              3%                                                  kaolinite                 13%                                                 ______________________________________                                    

The ingredients are blended, hammer-milled until all the solids areessentially under 50 microns, re-blended, and packaged.

EXAMPLE 13 Wettable Powder

    ______________________________________                                        N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-                                                          50%                                               6,7-dihydro-5H--thieno[3,2-B]thiopyran-3-                                     sulfonamide, 4,4-dioxide                                                      sodium alkylnaphthalenesulfonate                                                                           2%                                               low viscosity methyl cellulose                                                                             2%                                               diatomaceous earth          46%                                               ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milledto produce particles essentially all below 10 microns in diameter. Theproduct is reblended before packaging.

EXAMPLE 14 Granule

    ______________________________________                                        Wettable Powder of Example 13                                                                        5%                                                     attapulgite granules  95%                                                     (U.S.S. 20-40 mesh; 0.84-0.42 mm)                                             ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on thesurface of attapulgite granules while tumbling in a double-cone blender.The granules are dried and packaged.

EXAMPLE 15 Extruded Pellet

    ______________________________________                                        N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-                                                          25%                                               5,6-dihydro-5-methylthieno[3,2-B]thiophene-                                   3-sulfonamide, 4,4-dioxide                                                    anhydrous sodium sulfate    10%                                               crude calcium ligninsulfonate                                                                              5%                                               sodium alkylnaphthalenesulfonate                                                                           1%                                               calcium/magnesium bentonite 59%                                               ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about12% water. The mixture is extruded as cylinders about 3 mm diameterwhich are cut to produce pellets about 3 mm long. These may be useddirectly after drying, or the dried pellets may be crushed to pass aU.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S.No. 40 sieve (0.42 mm openings) may be packaged for use and the finesrecycled.

EXAMPLE 16 Oil Suspension

    ______________________________________                                        N--[(4-methoxy-6-methyltriazin-2-yl)amino-                                                             25%                                                  carbonyl]-5,6-dihydro-5-methylthieno[3,2-B]-                                  thiophene sulfonamide, 4,4-dioxide                                            polyoxyethylene sorbitol hexaoleate                                                                     5%                                                  highly aliphatic hydrocarbon oil                                                                       70%                                                  ______________________________________                                    

The ingredients are ground together in a sand mill until the solidparticles have been reduced to under about 5 microns. The resultingthick suspension may be applied directly, but preferably after beingextended with oils or emulsified in water.

EXAMPLE 17 Wettable Powder

    ______________________________________                                        N--[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-                                                      20%                                              5,6-dihydro-5-methylthieno[3,2-B]thiophene-                                   3-sulfonamide, 4,4-dioxide                                                    sodium alkylnaphthalenesulfonate                                                                           4%                                               sodium ligninsulfonate       4%                                               low viscosity methyl cellulose                                                                             3%                                               attapulgite                  69%                                              ______________________________________                                    

The ingredients are thoroughly blended. After grinding in a hammer-millto produce particles essentially all below 100 microns, the material isre-blended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) andpackaged.

EXAMPLE 18 Low Strength Granule

    ______________________________________                                        N--[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]                                                       1%                                               5,6-dihydro-5-methylthieno[3,2-B]thiophene-                                   3-sulfonamide, 4,4-dioxide                                                    N,N--dimethylformamide       9%                                               attapulgite granules         90%                                              (U.S.S. 20-40 sieve)                                                          ______________________________________                                    

The active ingredient is dissolved in the solvent and the solution issprayed upon dedusted granules in a double cone blender. After sprayingof the solution has been completed, the blender is allowed to run for ashort period and then the granules are packaged.

EXAMPLE 19 Aqueous Suspension

    ______________________________________                                        N--[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-                                                     40%                                               6,7-dihydro-5H--thieno[3,2-B]thiopyran-3-                                     sulfonamide, 4,4-dioxide                                                      polyacrylic acid thickener  0.3%                                              dodecylphenol polyethylene glycol ether                                                                   0.5%                                              disodium phosphate           1%                                               monosodium phosphate        0.5%                                              polyvinyl alcohol           1.0%                                              water                       56.7%                                             ______________________________________                                    

The ingredients are blended and ground together in a sand mill toproduce particles essentially all under 5 microns in size.

EXAMPLE 20 Solution

    ______________________________________                                        N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-                                                          5%                                                5,6-dihydro-5methlthieno[3,2-B]thiophene-3-                                   sulfonamide, 4,4-dioxide, sodium salt                                                                     5%                                                water                      95%                                                ______________________________________                                    

The salt is added directly to the water with stirring to produce thesolution, which may then be packaged for use.

EXAMPLE 21 Low Strength Granule

    ______________________________________                                        N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-6,7-                                                       0.1%                                             dihydro-5H--thieno[3,2-B]thiopyran-3-sulfonamide,                             4,4-dioxide                                                                   attapulgite granules        99.9%                                             (U.S.S. 20-40 mesh)                                                           ______________________________________                                    

The active ingredient is dissolved in a solvent and the solution issprayed upon dedusted granules in a double-cone blender. After sprayingof the solution has been completed, the material is warmed to evaporatethe solvent. The material is allowed to cool and then packaged.

EXAMPLE 22 Granule

    ______________________________________                                        N--[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-                                                      80%                                                5,6-dihydro-5-methlthieno[3,2-B]-thiophene-3-                                 sulfonamide-4,4-dioxide                                                       wetting agent               1%                                                crude ligninsulfonate salt (containing                                                                   10%                                                5-20% of the natural sugars)                                                  attapulgite clay            9%                                                ______________________________________                                    

The ingredients are blended and milled to pass through a 100 meshscreen. This material is then added to a fluid bed granulator, the airflow is adjusted to gently fluidize the material, and a fine spray ofwater is sprayed onto the fluidized material. The fluidization andspraying are continued until granules of the desired size range aremade. The spraying is stopped, but fluidization is continued, optionallywith heat, until the water content is reduced to the desired level,generally less than 1%. The material is then discharged, screened to thedesired size range, generally 14-100 mesh (1410-149 microns), andpackaged for use.

EXAMPLE 23 High Strength Concentrate

    ______________________________________                                        N--[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]-                                                    99%                                                5,6-dihydro-5-methylthieno[3,2-B]thiophene-                                   3-sulfonamide, 4,4-dioxide                                                    silica aerogel             0.5%                                               synthetic amorphous silica 0.5%                                               ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce amaterial essentially all passing a U.S.S. No. 50 screen (0.3 mmopening). The concentrate may be formulated further if necessary.

EXAMPLE 24 Wettable Powder

    ______________________________________                                        N--[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-                                                    90%                                                6,7-dihydro-5H--thieno[3,2-B]thiopyran-3-                                     sulfonamide, 4,4-dioxide                                                      dioctyl sodium sulfosuccinate                                                                            0.1%                                               synthetic fine silica      9.9%                                               ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produceparticles essentially all below 100 microns. The material is siftedthrough a U.S.S. No. 50 screen and then packaged.

EXAMPLE 25 Wettable Powder

    ______________________________________                                        N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-6,7-                                                     40%                                                dihydro-5H--thieno[3,2-B]thiopyran-3-sulfonamide,                             4,4-dioxide                                                                   sodium ligninsulfonate     20%                                                montmorillonite clay       40%                                                ______________________________________                                    

The ingredients are thoroughly blended, coarsely hammer-milled and thenair-milled to produce particles essentally all below 10 microns in size.The material is reblended and then packaged.

EXAMPLE 26 Oil Suspension

    ______________________________________                                        N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-5,6-                                                     35%                                                dihydro-5-methylthieno[3,2-B]thiophene-3-                                     sulfonamide, 4,4-dioxide                                                      blend of polyalcohol carboxylic                                                                           6%                                                esters and oil soluble petroleum                                              sulfonates                                                                    xylene                     59%                                                ______________________________________                                    

The ingredients are combined and ground together in a sand mill toproduce particles essentially all below 5 microns. The product can beused directly, extended with oils, or emulsified in water.

EXAMPLE 27 Dust

    ______________________________________                                        N--[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-                                                      10%                                                5,6-dihydro-5-methylthieno[3,2-B]thiophene-3-                                 sulfonamide, 4,4-dioxide                                                      attapulgite                10%                                                pyrophyllite               80%                                                ______________________________________                                    

The active ingredient is blended with attapulgite and then passedthrough a hammer-mill to produce particles substantially all below 200microns. The ground concentrate is then blended with powderedpyrophyllite until homogeneous.

UTILITY

Test results indicate that the compounds of the present invention areactive herbicides. Many of the compounds have utility for broad-spectrumpre- and/or post-emergence weed control in areas where complete controlof all vegetation is desired, such as around fuel storage tanks,ammunition depots, industrial storage areas, parking lots, drive-intheaters, around billboards, highway and railroad structures.Alternatively, many of the subject compounds should be useful for plantgrowth modification, such as growth retardation. Some of the compoundswhen used at lower rates of application are selective on certain crops,e.g., cotton.

The rates of application for the compounds of the invention aredetermined by a number of factors, including their use as selective orgeneral herbicides, the crop species involved, the types of weeds to becontrolled, weather and climate, formulations selected, mode ofapplication, amount of foliage present, etc. In general terms, thesubject compounds should be applied at levels of around 50 to 1000 g/ha,the lower rates being suggested for use on lighter soils and/or thosehaving a low organic matter content, for plant growth modification orfor situations where only short-term persistence is required.

The compounds of the invention may be used in combination with any othercommercial herbicide examples of which are those of the triazine,triazole, uracil, urea, amide, diphenylether, carbamate and bipyridyliumtypes. Combinations with mefluidide are useful as well.

The herbicidal and plant growth modifying properties of the subjectcompounds were discovered in the greenhouse. The test procedures andresult follow.

COMPOUNDS ##STR46## TEST A

Seeds of crabgrass (Digitaria sp.), barnyardgrass (Echinochloacrusgalli), wild oats (Avena fatua), sicklepod (Cassia obtusifolia),morningglory, (Ipomoea sp.), cocklebur (Xanthium pensylvanicum),sorghum, corn, soybean, cotton, sugar beet, rice, wheat and purplenutsedge (Cyperus rotundus) tubers were planted in a growth medium andtreated pre-emergence with the chemicals dissolved in a non-phytofoxicsolvent. It will be noted in the data that in some instances velvetleaf(Abutilon theophrasti) has been substituted for sicklepod (Cassiaobtusifolia). At the same time, these crop and weed species were treatedwith a soil/foliage application. At the time of treatment, the plantsranged in height from 2 to 18 cm. Treated plants and controls weremantained in a greenhouse for sixteen days, after which all species werecompared to controls and visually rated for response to treatment. Theratings, summarized in Table A, are based on a numerical scale extendingfrom 0=no injury, to 10=complete kill. The accompanying descriptivesymbols have the following meanings:

C=chlorosis or necrosis;

E=emergence inhibition;

G=growth retardation;

H=formative effect; and

U=unusual pigmentation.

                                      TABLE A                                     __________________________________________________________________________            Compound 1                                                                            Cmpd. 2                                                                            Cmpd. 3                                                                            Cmpd. 4                                                                              Cmpd. 5 Cmpd. 6                                                                            Cmpd. 7                                                                            Cmpd. 8                    Rate (kg/ha)                                                                          0.05                                                                              2.0 0.05 0.05 0.05                                                                             2.0 0.05                                                                              2.0 0.05 0.05 0.05                       __________________________________________________________________________    POST-EMERGENCE                                                                Cotton  0   2C,9G                                                                             4C,8H                                                                              2C,9H                                                                              0  2C,7H                                                                             0   1C,2G                                                                             5G   4C,9G                                                                              10C                        Morningglory                                                                          0   1C  4C,8H                                                                              4C,8H                                                                              0  0   0   2G  3G   4C,8H                                                                              5C,9G                      Cocklebur                                                                             0   1C,2G                                                                             4C,8H                                                                              3C,8G                                                                              0  0   0   3G  5G   4C,8H                                                                              9C                         Sicklepod                                                                             0   0   4C,6H                                                                              4C,8H                                                                              0  0   0   1C  0                                    Nutsedge                                                                              0   0   0    2C,5G                                                                              0  0   0   0   0    2C,8G                                                                              4C,8G                      Crabgrass                                                                             0   0   2C,4H                                                                              2C,7G                                                                              0  1C,3G                                                                             0   1C,3G                                                                             2G   3C,7G                                                                              9C                         Barnyardgrass                                                                         0   1H  5C,9H                                                                              5C,9H                                                                              0  3C,8H                                                                             0   4C,9H                                                                             9H   3C,7H                                                                              9C                         Wild Oats                                                                             0   1C,5G                                                                             4C,9G                                                                              5C,9G                                                                              0  4C,9G                                                                             0   5C,9G                                                                             0    3C,5G                                                                              4C,8G                      Wheat   0   2C,8G                                                                             4C,9G                                                                              5C,9G                                                                              0  4C,9G                                                                             0   4C,9G                                                                             0    2C,6G                                                                              4C,9G                      Corn    0   0   3U,9G                                                                              4U,9G                                                                              0  2C,6H                                                                             0   2U,9H                                                                             2C,8H                                                                              3C,9H                                                                              10C                        Soybean 0   0   4C,8G                                                                              4H,9G                                                                              0  2C,4H                                                                             0   2H,5G                                                                             2G   4C,8H                                                                              5C,9G                      Rice    0   5G  5C,9G                                                                              9C   0  4C,9G                                                                             0   3C,9G                                                                             5C,9G                                                                              5C,9G                                                                              9C                         Sorghum 0   1C  4C,9H                                                                              4C,9H                                                                              0  3C,7H                                                                             0   3C,9H                                                                             2C,9H                                                                              3C,7G                                                                              9C                         Sugar beet                                                                            0   2H  4C,8H                                                                              9C   0  0   0   1C,3H                                                                             5G   9C   10C                        Velvetleaf                                    4C,9G                                                                              9C                         Cheatgrass                                    4C,9G                                                                              9C                         PRE-EMERGENCE                                                                 Morningglory                                                                          0   2C  1H   7H   0  0   0   1C  3C,5G                                                                              7H   9G                         Cocklebur                                                                             0   9G  3H   8H   0  2H  0   2H  0    --   8H                         Sicklepod                                                                             0   2H  0    7G   0  0   0   3G  0                                    Nutsedge                                                                              0   2C,5G                                                                             0    0    0  0   0   0   0    5G   8G                         Crabgrass                                                                             0   0   0    3G   0  0   0   0   0    2C,5G                                                                              4C,8G                      Barnyardgrass                                                                         0   0   0    2C   0  0   0   0   0    0    2C,6H                      Wild Oats                                                                             0   2C,7G                                                                             0    4C,9G                                                                              0  2C,5G                                                                             0   8G  0    0    0                          Wheat   0   8G  0    9C   0  7G  0   1C,7G                                                                             0    0    2G                         Corn    0   2C,9H                                                                             2C,6G                                                                              3C,9H                                                                              0  2C,8G                                                                             0   3C,8H                                                                             2G   3C,8H                                                                              4C,9G                      Soybean 0   2C  2C   8H   0  0   0   1H  0    2C,5G                                                                              4C,7G                      Rice    0   3C,7H                                                                             2G   10E  0  2C,9G                                                                             0   2C,5G                                                                             5G   3C,7G                                                                              10E                        Sorghum 0   3C,8G                                                                             3C,4G                                                                              4C,9H                                                                              0  2C  0   0   2C,9H                                                                              3C,8H                                                                              4C,9H                      Sugar beet                                                                            0   4C,8H                                                                             2C   2C,9G                                                                              0  0   0   0   0    8G   4C,9G                      Cotton  0   6G  2C   9G   0  0   0   2G  1C   8G   9G                         Velvetleaf                                    7G   10E                        Cheatgrass                                    2C,7G                                                                              4C,9H                      __________________________________________________________________________            Cmpd. 9                                                                             Cmpd. 10                                                                           Cmpd. 11                                                                            Cmpd. 12                                                                            Cmpd. 13                                                                             Cmpd. 14                                                                            Cmpd. 15                                                                            Cmpd. 16                    Rate (kg/ha)                                                                          0.05  0.05 0.05  0.05  0.05   0.05  0.05  0.05                        __________________________________________________________________________    POST-EMERGENCE                                                                Cotton  9C    5C,9G                                                                              5C,9G 10C   9C     9C    9C    9C                          Morningglory                                                                          10C   4C,9G                                                                              2C,6G 3G    9C     10C   10C   9C                          Cocklebur                                                                             10C   10C  2C,9H 0     10C    10C   10C   10C                         Sicklepod                                                                     Nutsedge                                                                              9C    0    2C,5G 0     9C     9C    10C   5C,9G                       Crabgrass                                                                             9C    9C   0     0     9C     10C   10C   9C                          Barnyardgrass                                                                         10C   9C   1C    0     9C     9C    9C    9C                          Wild Oats                                                                             9C    1C   0     0     6C,9G  9C    6C,9G 2C,5G                       Wheat   10C   2C,4G                                                                              0     0     9C     9C    9C    2C,5G                       Corn    9C    5C,9G                                                                              3C,9G 2C,6H 10C    10C   10C   10C                         Soybean 5C,9G 4C,9G                                                                              4C,9G 4C,9G 6C,9G  5C,9G 6C,9G 4C,9H                       Rice    9C    9C   4C,9G 2C,8G 6C,9G  6C,9G 9C    9C                          Sorghum 10C   9C   3C,7H 2C,4G 9C     10C   9C    10C                         Sugar beet                                                                            9C    9C   9C    3C,7H 9C     9C    9C    9C                          Velvetleaf                                                                            9C    4C,8G                                                                              4C,9G 4C,9G 9C     9C    9C    9C                          Cheatgrass                                                                            9C    3C,7G                                                                              1C    0     6C,9G  5C,9G 9C    5C,9G                       PRE-EMERGENCE                                                                 Morningglory                                                                          9C    9H   2C,6G 5G    9G     9G    9C    9H                          Cocklebur                                                                             8H    9H   6H    0     9H     9H    9H    9H                          Sicklepod                                                                     Nutsedge                                                                              10E   3C,5G                                                                              0     0     10E    10E   10E   10E                         Crabgrass                                                                             4C,8G 3C,7G                                                                              0     0     5C,9G  9C    9C    4C,8G                       Barnyardgrass                                                                         4C,9H 3C,9H                                                                              0     0     3H     2C,9H 3C,9H 5C,9H                       Wild Oats                                                                             4C,8G 1C   0     0     2C,8G  4C,9H 4C,9H 7G                          Wheat   10H   1C   0     0     9G     7C,9H 7C,9H 6G                          Corn    4C,9H 2C,9H                                                                              7G    2C,2G 3C,9G  10H   5C,9H 5C,9H                       Soybean 3C,7G 3C,7G                                                                              2C,4H 0     3C,7H  9H    3C,8H 4C,7H                       Rice    10E   10E  3G    2C,5G 10E    10E   10E   10E                         Sorghum 4C,9H 5C,9H                                                                              0     0     5C,9H  6C,9H 7C,9H 10H                         Sugar beet                                                                            9C    5C,9G                                                                              8H    6G    9C     5C,9G 5C,9G 9C                          Cotton  9G    9G   9G    9G    9G     9G    9C    9G                          Velvetleaf                                                                            5C,9G 2C,8G                                                                              6G    2G    5C,9G  5C,9G 10C   5C,9G                       Cheatgrass                                                                            5C,9H 3C,8G                                                                              0     0     10E    10E   10E   9G                          __________________________________________________________________________            Cmpd. 17                                                                            Cmpd. 18                                                                            Cmpd. 19                                                                            Cmpd. 20                                                                            Cmpd. 21                                                                            Cmpd. 22                                                                            Cmpd. 23                                                                            Cmpd. 24                    Rate (kg/ha)                                                                          0.05  0.05  0.05  0.05  0.05  0.05  0.05  0.05                        __________________________________________________________________________    POST-EMERGENCE                                                                Cotton  3C,5G 1C    7G    9C    9C    4C,9G 9C    5C,9G                       Morningglory                                                                          5G    2G    4G    5C,9G 5C,9G 2C,8G 9C    10C                         Cocklebur                                                                             2H,7G 4G    2C,8G 9C    2C,6G 4G    9C    2G                          Sicklepod                                                                     Nutsedge                                                                              4G    5G    4G    2C,8G 10C   2C,6G 5G    4G                          Crabgrass                                                                             2G    0     2G    2G    5G    0     0     0                           Barnyardgrass                                                                         3C,9H 3C,8H 2H    3C,8H 2H    0     2C,6H 0                           Wild Oats                                                                             4C,9G 5C,9G 0     1C    0     0     0     0                           Wheat   3C,9G 5C,9G 0     0     0     0     0     0                           Corn    5C,9G 9C    2G    2C,8H 0     0     2C,9H 2C,3H                       Soybean 2H,3G 3H,5G 2C,6H 5C,9G 5C,9G 5H    5C,9G 5C,9G                       Rice    5C,9G 5C,9G 7G    4C,9G 3C,8G 4G    4C,9G 5C,9G                       Sorghum 5C,9H 4C,9H 2G    2C,8H 2H    0     3C,8H 2C,5H                       Sugar beet                                                                            3C,6H 3C,7G 4C,9H 9C    10C   2C,7G 9C    5C,9G                       Velvetleaf                                                                            3C,8H 3H    4C,9H 10C   10C   8G    9C    10C                         Cheatgrass                                                                            3C,8G 2C,7G 0     4G    4G    0     4G    0                           PRE-EMERGENCE                                                                 Morningglory                                                                          5G    7G    2C,5G 9G    9G    8G    9G    9G                          Cocklebur                                                                             --    5G    5H    3C,8G 7G    5H    9H    6G                          Sicklepod                                                                     Nutsedge                                                                              0     0     0     9G    10E   0     5G    5G                          Crabgrass                                                                             0     0     0     5G    2C,4G 0     0     0                           Barnyardgrass                                                                         0     0     0     3C,8H 3C,7H 0     2G    3H                          Wild Oats                                                                             2C,8G 2C,8G 0     2C,5G 0     0     0     2G                          Wheat   8G    5G    0     5G    2G    0     0     0                           Corn    4C,9G 4C,9H 4G    2C,8G 9G    5G    2C,8G 2C,7G                       Soybean 0     0     2C,2H 3C,7H 7H    3G    3C,7H 3C,5H                       Rice    9H    9H    2C,7G 4C,9H 9H    5G    10E   9H                          Sorghum 2C,8H 3C,7H 2C    4C,8H 4C,9H 5G    3C,8H 2C,6H                       Sugar beet                                                                            6G    3C,7G 9G    10C   10E   8G    9C    9C                          Cotton  0     5G    8G    9G    9G    7G    9G    9G                          Velvetleaf                                                                            0     2C    5G    9C    9G    6G    9C    2C,9G                       Cheatgrass                                                                            3G    3G    5G    5G    6G    2G    3G    0                           __________________________________________________________________________

TEST B Post-emergence

Two round pans (25 cm diameter by 12.5 cm deep) were filled withWoodstown sandy loam soil. One pan was planted with blackgrass(Alopecurus myosuroides), sugar beets, nutsedge (Cyperus rotundus)tubers, crabgrass (Digitaria sanguinalis), sicklepod (Cassiaobtusifolia), teaweed (Sida spinosa), jimsonweed (Datura stramonium),velvetleaf (Abutilon theophrasti), and giant foxtail (Setaria faberii).The other pan was planted with wheat, cotton, rice, corn, soybean, wildoats (Avena fatua), cocklebur (Xanthium pensylvanicum), morningglory(Ipomoea hederacea), johnsongrass (Sorghum halepense) and barnyardgrsss(Echinochloa crusgalli). The plants were grown for approximatelyfourteen days, then sprayed post-emergence with the chemicals dissolvedin a non-phytotoxic solvent.

Pre-emergence

Two round pans (25 cm diameter by 12.5 cm deep) were filled withWoodstown sandy loam soil. One pan was planted with blackgrass(Alopecurus myosuroides), sugar beets, nutsedge, crabgrass, sicklepod,teaweed, jimsonweed, velvetleaf, and giant foxtail. The other pan wasplanted with wheat, cotton, rice, corn, soybean, wild oats, cocklebur,morningglory, johnsongrass and barnyardgrass. The two pans were sprayedpre-emergence with the chemicals dissolved in a non-phytotoxic solvent.

Treated plants and controls were maintained in the greenhouse for 28days, then all treated plants were compared to controls and visuallyrated for plant response.

Response ratings are based on a scale of 0 to 10: where 0=no effect, and10=complete control. The type of response is indicated by letters whereG=growth retardation and C=chlorosis and/or necrosis.

Response ratings are contained in Table B.

                  TABLE B                                                         ______________________________________                                                  Pre-                                                                          Emergence     Post-Emergence                                        Rate g/ha   16      62      1    4    16   62                                 ______________________________________                                        Compound Number 2                                                             Corn        0       0       2G   3G   5G   9G                                 Wheat       0       0       0    0    0    6G                                 Rice        0       0       0    0    3G   10G                                Soybean     0       0       0    0    3G   5G                                 Cotton      0       0       0    0    0    4G                                 Sugar beet  0       0       0    0    2G   5G                                 Crabgrass   0       0       0    2G   4G   5G                                 Johnsongrass                                                                              0       0       0    0    0    3G                                 Blackgrass  0       0       0    0    0    3G                                 Barnyardgrass                                                                             0       0       0    0    0    0                                  Nutsedge    0       0       0    0    0    0                                  Giant foxtail                                                                             0       0       0    0    0    4G                                 Wild Oats   0       0       0    0    3G   8G                                 Cocklebur   0       0       0    0    0    0                                  Morningglory                                                                              0       0       0    0    0    3G                                 Teaweed     0       2G      0    0    3G   7G                                 Sicklepod   0       0       0    2G   5G   9G                                 Jimsonweed  0       0       0    0    2G   4G                                 Velvetleaf  0       0       0    0    2G   6G                                 Compound Number 3                                                             Corn        0       0       2G   7G   10C  10C                                Wheat       0       0       0    3G   8C   10C                                Rice        3G      9G      2G   8G   10G  10C                                Soybean     0       2G      0    2G   8G   10G                                Cotton      0       0       0    0    2G   8G                                 Sugar beet  0       5G      0    5G   9G   10G                                Crabgrass   0       5G      0    0    6G   9G                                 Johnsongrass                                                                              3G      9G      0    3G   9G   10C                                Blackgrass  4G      8G      0    3G   9C   10C                                Barnyardgrass                                                                             0       0       0    0    3G   10C                                Nutsedge    4G      9G      0    0    0    0                                  Giant foxtail                                                                             5G      8G      0    0    3G   10G                                Wild Oats   0       3G      0    3G   8G   10C                                Cocklebur   0       0       0    0    3G   9G                                 Morningglory                                                                              0       0       0    0    2G   8G                                 Teaweed     0       0       0    2G   7G   8G                                 Sicklepod   0       0       0    5G   9G   10G                                Jimsonweed  0       0       0    3G   6G   7G                                 Velvetleaf  0       0       0    3G   8G   9G                                 ______________________________________                                    

What is claimed is:
 1. A compound of the formula: ##STR47## wherein J is##STR48## E is a bridge of 3 or 4 atoms, which may be substituted orunsubstituted, containing 0-2 heteroatoms selected from the groupconsisting of oxygen, sulfur and nitrogen and also containing 1-4 atomsof carbon, said bridge together with two carbon attachment sites forminga partially saturated 5 to 6 membered carboxyclic or heterocyclic ring;or E is a bridge of 3 or 4 atoms which may be substituted orunsubstituted containing at least 1 heteroatom selected from 0-1 oxygenor sulfur or 0-2 nitrogen and 1-3 atoms of carbon said bridge togetherwith two carbon attachment sites forming an unsaturated 5 to 6 memberedheterocyclic ring, with the proviso that when E contains two atoms ofoxygen or sulfur, then they must be separated by at least one atom ofcarbon and that oxygen and sulfur are only linked to each other if thesulfur is in the form of SO or SO₂ ; in the bridging group E nitrogenmay take the form of N or N--O, sulfur may take the form of S, SO orSO₂, and one of the atoms of carbon may be a carbonyl, thiocarbonyl orthe cyclic 5 and 6 membered ketals thereof; when one of the bridgingatoms is a substituted carbon, the substituent on said carbon isselected from H, halogen, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₃ -C₄alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl, C₃ -C₄ haloalkynyl, C₁ -C₃alkoxycarbonyl, CN, NO₂, OH, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy, C₁ -C₃alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, C₁ -C₃alkylcarbonyl, C₁ -C₃ alkylsulfamoyl, di(C₁ -C₃ alkyl)sulfamoyl and C₁-C₂ alkyl substituted with C₁ -C₂ alkoxy, C₁ -C₂ alkylthio or CN; whenat least one of the bridging atoms is a nitrogen (other than nitrogen inthe form of R₆ NSO₂ in J₇, J₈, J₁₁ and J₁₂) substituents on saidnitrogen are selected from H, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₃ -C₄alkenyl, C₃ -C₄ haloalkenyl, C₃ -C₄ alkynyl, C₃ -C₄ haloalkynyl, C₁ -C₃alkoxy, C₁ -C₄ alkylcarbonyl, C₁ -C₃ alkoxycarbonyl, C₁ -C₃alkylaminocarbonyl or C₁ -C₄ alkylsulfonyl; when at least one of thebridging atoms is a nitrogen, in the form of R₆ NSO₂ as in J₇, J₈, J₁₁and J₁₂, the nitrogen substituents are as defined for R₆ ;G is O, S, NHor NCH₃ ; W is O or S; R is H or CH₃ ; R₁ is H, F, Cl, Br, NO₂, C₁ -C₃alkyl, C₁ -C₃ haloalkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy, S(O)_(p) C₁-C₃ alkyl, S(O)_(p) C₁ -C₃ haloalkyl, CO₂ (C₁ -C₃ alkyl), CO₂ (C₁ -C₃haloalkyl), OCH₂ C═CHR_(a), OCH₂ C.tbd.CR_(a), CO₂ (CH₂ CH═CHR_(a)), CO₂(CH₂ C.tbd.CR_(a)) or SO₂ NR_(b) R_(c) ; R₁ ' is H, CH₃, F or Cl; p is0, 1 or 2;R_(a) is H or CH₃ ; R_(b) is H, C₁ -C₃ alkyl or C₁ -C₃haloalkyl; R_(c) is H, C₁ -C₃ alkyl or C₁ -C₃ haloalkyl; A is ##STR49##X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃ alkyl)amino; Y is H,C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁-C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino,C₁ -C₃ alkylamino, di-(C₁ -C₃ -alkyl)amino, C₃ -C₄ alkenyloxy, C₃ -C₄alkynyloxy, C₂ -C₅ alkylthioalkyl, C₂ -C₅ alkylsulfinylalkyl, C₂ -C₅alkylsulfonylalkyl, C₁ -C₄ haloalkyl, C₃ -C₅ cycloalkyl, C₂ -C₄ alkynyl,##STR50## or N(OCH₃)CH₃ ; W₁ and W₁ ' are independently O or S; m is 2or 3; R_(d) is H or CH₃ ; R_(e) is C₁ -C₂ alkyl; R_(f) is C₁ -C₂ alkyl;Z is CH, CCH₃, CC₂ H₅, CCl or CBr; R₆ is H, R₈, SR₈, SO₂ R₈, OR₈,C(O)R₈, C(O)L, (CO)₂ OR₈, (CO)₂ R₈, C(O)NR₉ R₁₀, C(O)NRA, C(S)SR₈, NH₂,NR₉ R₁₀, OH, CN, P(O)R₁₁ R₁₂, P(S)R₁₁ R₁₂ or Si(CH₃)₂ R₁₃ ; R₇ is H, C₁-C₆ alkyl, Cl, Br, CN, NO₂, SR₁₃, SO₂ R₁₃, CO₂ R₁₃ or C(O)R₁₃ ; R₈ is C₁-C₁₀ alkyl, C₁ -C₁₀ alkoxyalkoxyalkyl, C₂ -C₁₀ alkenyl, C₂ -C₁₀epoxyalkyl, C₂ -C₁₀ alkynyl, C₃ -C₆ cycloalkyl, C₄ -C₇ cycloalkylalkylor phenyl optionally substituted with R₁₄ ; when R₈ is C₃ -C₆ cycloalkylor C₄ -C₇ cycloalkylalkyl, it may optionally be substituted by C₁ -C₄alkyl, 1 to 3 atoms of Cl or F or 1 Br; when R₈ is C₁ -C₁₀ alkyl, C₂-C₁₀ alkenyl or C₂ -C₁₀ alkynyl, it may optionally be substituted by oneor more halogens and/or by (R₁₅)_(r) provided that when r is 2, thevalues of R₁₅ may be identical or different; R₉ is H or C₁ -C₄ alkyl;R₁₀ is H, C₁ -C₁₀ alkyl, C₁ -C₁₀ haloalkyl, C₂ -C₁₀ alkenyl, C₂ -C₁₀alkynyl, C₃ -C₆ cycloalkyl or phenyl substituted with R₁₄ ; R₁₁ and R₁₂are independently C₁ -C₄ alkyl, C₁ -C₄ alkoxy or C₁ -C₄ alkylthio; R₁₃is C₁ -C₁₀ alkyl, benzyl or phenyl optionally substituted with R₁₄ ; R₁₄is H, F, Cl, Br, CH₃, OCH₃, NO₂, CN, SCH₃, SO₂ CH₃ or CF₃ ; r is 1 or 2;R₁₅ is OR₁₀, OC(O)R₁₀, OC(O)NR₉ R₁₀, OSO₂ R₁₀, OP(O)R₁₁ R₁₂, OSi(CH₃)₂R₁₃, SR₁₀, SOR₁₀, SO₂ R₁₀, SCN, CN, SP(O)R₁₁ R₁₂, SP(S)R₁₁ R₁₂, P(O)R₁₁R₁₂, P(S)R₁₁ R₁₂, NR₉ R₁₀, N⁺ R₉ R₁₀ R₁₃, NR₉ C(O)R₁₀, NR₉ C(O)OR₁₀, NR₉C(O)NR₉ R₁₀, NR₉ SO₂ R₁₀, NR₉ P(O)R₁₁ R₁₂, NR₉ P(S)R₁₁ R₁₂, NO₂,C(O)R₁₀, C(O)OR₁₀, C(O)NR₉ R₁₀, C(R₁₀)═NOR₁₀, naphthyl, L, phenyloptionally substituted with R₁₄ and/or R₁₆, ##STR51## R₁₆ is H, F, Cl,Br, phenoxy optionally substituted with R₁₄, or phenyl optionallysubstituted with R₁₄ ; L is selected from pyridine, thiophene, furan,cyclopentanone, α-butyrolactone, triazole and oxazole;provided that (a)when W is S, then R is H, A is A-1, and Y is CH₃, OCH₃, OC₂ H₅, CH₂OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃,CH(OCH₃)₂ or ##STR52## (b) when X is Cl, F, or BR, then Y is OCH₃, OC₂H₅, NH₂, NHCH₃, N(CH₃)₂ or OCF₂ H; (c) the total number of carbon atomsin R₆ is less than or equal to 13; (d) when the total number of carbonatoms of X and Y is greater than four, then the number of carbon atomsof R₁ is less than or equal to two, and the number of carbon atoms of R₆is less than or equal to four;and their agriculturally suitable salts.2. A compound of claim 1 wherein J is ##STR53## Q is O, S, SO, SO₂, CH₂or CHCH₃ ; Q₁ is O, S, CH₂ or NR₄ ;W₂ is O or S; R₂ is H, F, Cl or C₁-C₄ alkyl; R₃ is H, F, Cl or CH₃ ; R₄ is H or C₁ -C₄ alkyl; R₅ is H orCH₃ ; R₆ is H, R₈, SR₈, SO₂ R₈, OR₈, C(O)R₈, C(O)L, (CO)₂ OR₈, (CO)₂ R₈,C(O)NR₉ R₁₀, C(O)NRA, C(S)SR₈, NH₂, NR₉ R₁₀, OH, CN, P(O)R₁₁ R₁₂,P(S)R₁₁ R₁₂ or Si(CH₃)₂ R₁₃ ; R₇ is H, C₁ -C₆ alkyl, Cl, Br, CN, NO₂,SR₁₃, SO₂ R₁₃, CO₂ R₁₃ or C(O)R₁₃ ; R₈ is C₁ -C₁₀ alkyl, C₁ -C₁₀alkoxyalkoxyalkyl, C₂ -C₁₀ alkenyl, C₂ -C₁₀ epoxyalkyl, C₂ -C₁₀ alkynyl,C₃ -C₆ cycloalkyl, C₄ -C₇ cycloalkylalkyl or phenyl optionallysubstituted with R₁₄ ; when R₈ is C₃ -C₆ cycloalkyl or C₄ -C₇cycloalkylalkyl, it may optionally be substituted by C₁ -C₄ alkyl, 1 to3 atoms of Cl or F or 1 Br; when R₈ is C₁ -C₁₀ alkyl, C₂ -C₁₀ alkenyl orC₂ -C₁₀ alkynyl, it may optionally be substituted by one or morehalogens and/or by (R₁₅)_(r) provided that when r is 2, the values ofR₁₅ may be identical or different; R₉ is H or C₁ -C₄ alkyl; R₁₀ is H, C₁-C₁₀ alkyl, C₁ -C₁₀ haloalkyl, C₂ -C₁₀ alkenyl, C₂ -C₁₀ alkynyl, C₃ -C₆cycloalkyl or phenyl substituted with R₁₄ ; R₁₁ and R₁₂ areindependently C₁ -C₄ alkyl, C₁ -C₄ alkoxy or C₁ -C₄ alkylthio; R₁₃ is C₁-C₁₀ alkyl, benzyl or phenyl optionally substituted with R₁₄ ; R₁₄ is H,F, Cl, Br, CH₃, OCH₃, NO₂, CN, SCH₃, SO₂ CH₃ or CF₃ ; R₁₅ is OR₁₀,OC(O)R₁₀, OC(O)NR₉ R₁₀, OSO₂ R₁₀, OP(O)R₁₁ R₁₂, OSi(CH₃)₂ R₁₃, SR₁₀,SOR₁₀, SO₂ R₁₀, SCN, CN, SP(O)R₁₁ R₁₂, SP(S)R₁₁ R₁₂, P(O)R₁₁ R₁₂,P(S)R₁₁ R₁₂, NR₉ R₁₀, N⁺ R₉ R₁₀ R₁₃, NR₉ C(O)R₁₀, NR₉ C(O)OR₁₀, NR₉C(O)NR₉ R₁₀, NR₉ SO₂ R₁₀, NR₉ P(O)R₁₁ R₁₂, NR₉ P(S)R₁₁ R₁₂, NO₂,C(O)R₁₀, C(O)OR₁₀, C(O)NR₉ R₁₀, C(R₁₀)═NOR₁₀, naphthyl, L, phenyloptionally substituted with R₁₄ and/or R₁₆, ##STR54## R₁₆ is H, F, Cl,Br, phenoxy optionally substituted with R₁₄, or phenyl optionallysubstituted with R₁₄ ; r is 1 or 2; R₁₇ is H, C₁ -C₃ alkyl, C₁ -C₃alkoxy, C₁ -C₃ alkoxycarbonyl, F, Cl or CN; R₁₈ is H, CH₃, C₁ -C₃alkoxy, F, Cl or OH; or R₁₇ and R₁₈ may be taken together to form --OCH₂CH₂ O-- or --OCH₂ CH₂ CH₂ O--; R₁₉ is H or C₁ -C₄ alkyl; R₂₀ is H or CH₃; R₂₁ and R₂₂ are independently H or CH₃ ; R₂₃ is C₁ -C₄ alkyl; R₂₄ isH, F, Cl, C₁ -C₃ alkyl or C₁ -C₃ alkoxy; R₂₅ is H, F, Cl or C₁ -C₃alkyl; R₂₆ is H, F, Cl or C₁ -C₂ alkyl; R₂₇ is H, F, Cl or CH₃ ; R₂₈ isH, C₁ -C₄ alkyl, Cl, Br, CN, NO₂, C₁ -C₃ alkylthio, C₁ -C₃alkylsulfonyl, C₁ -C₃ alkoxycarbonyl or C₁ -C₃ alkylcarbonyl; R₂₉ is H,CH₃, Cl or Br; R₃₀ is H, CH₃, Cl or Br; R₃₁ is H or CH₃ ; R₃₂ is H or C₁-C₄ alkyl; R₃₃ is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkylthio, F orCl; n is 0 or 1; p' is 0, 1 or 2; and q is 0 or 1;provided that (a) thetotal number of carbon atoms in R₂ and R₃ is less than or equal to 4;(b) when J is J₁ or J₂, then R₂ and R₃ are other than F or Cl; (c) thetotal number of carbons atoms in R₄ and R₅ is less than or equal to 4;(d) when J is J₅, J₆, J₂₇, J₂₈, J₂₉, J₃₀, J₃₁, J₃₂, J₃₃, J₃₄, J₄₁, J₄₂,J₄₃ or J₄₄ and n is 0, then R₄ and/or R₅ is H; (e) when J is J₆₁ or J₆₂and n is 0, then R₄ is H or CH₃ ; (f) when R₁₇ is C₁ -C₃ alkoxy, thenR₁₈ is H, CH₃ or C₁ -C₃ alkoxy; and when R₁₈ is C₁ -C₃ alkoxy, then R₁₇is not F, or Cl; and (g) when R₁₈ is OH, then R₁₇ is H or C₁ -C₃ alkyl.3. A compound of claim 2 wherein R is H; W is O; and G is O or S.
 4. Acompound of claim 3 wherein X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, I, OCF₂H, CH₂ F, CF₃, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃, CH₂ Cl or CH₂ Br; and Yis H , CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CH₂ CH₃,CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, CH₂ OCH₂ CH₃, OCH₂ CH₂ OCH₃, CH₂SCH₃, CH₂ SCH₂ CH₃, ##STR55## OCF₂ H, SCF₂ H, C.tbd.CH or C.tbd.CCH₃. 5.A compound of claim 4 wherein G is S; R₁ is H, Cl, Br or CH₃ ; R₂ and R₄are H or C₁ -C₃ alkyl; R₃ is H or CH₃ ; R₆ is H, R₈, C(O)R₈ or CO₂ R₈ ;R₇ is H, C₁ -C₂ alkyl, Cl, Br, SC₁ -C₂ alkyl, SO₂ C₁ -C₂ alkyl, CO₂ C₁-C₂ alkyl or C(O)C₁ -C₂ alkyl; R₈ is C₁ -C₆ alkyl, C₁ -C₆ haloalkyl, C₂-C₆ alkenyl, C₂ -C₆ haloalkenyl, C₂ -C₆ alkynyl, C₃ -C₆ epoxyalkyl or C₁-C₄ alkyl substituted with C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂alkylsulfonyl, C₁ -C₂ alkylsulfonyl, CO₂ (C₁ -C₂ alkyl), C(O)C₁ -C₂alkyl, CN or OH. R₁₇ is H, C₁ -C₃ alkyl, C₁ -C₂ alkoxy or C₁ -C₂alkoxycarbonyl; R₁₈ is H, CH₃, C₁ -C₂ alkoxy or OH; or R₁₇ and R₁₈ maybe taken together to form --OCH₂ CH₂ O-- or --OCH₂ CH₂ CH₂ O--; R₂₈ isH, C₁ -C₃ alkyl, Cl, Br or NO₂ ; and R₃₃ is H or CH₃.
 6. A compound ofclaim 5 wherein R₈ is C₁ -C₆ alkyl, C₁ -C₄ haloalkyl, C₃ -C₄ alkenyl, C₃-C₄ haloalkenyl, C₃ -C₄ alkynyl, or C₁ -C₃ alkyl substituted with C₁ -C₂alkoxy, C₁ -C₂ alkylthio, C₁ -C₂ alkylsulfonyl, CN, CO₂ (C₁ -C₂ alkyl)or C(O)C₁ -C₂ alkyl.
 7. A compound of claim 6 wherein A is A-1; X isCH₃, OCH₃, OCH₂ CH₃, Cl, OCF₂ H or OCH₂ CF₃ ; and Y is CH₃, OCH₃, C₂ H₅,CH₂ OCH₃, NHCH₃ or CH(OCH₃)₂.
 8. A compound of claim 7 wherein J is J₁or J₂.
 9. A compound of claim J wherein J is J₃ or J₄.
 10. A compound ofclaim 7 wherein J is J₅ or J₆.
 11. A compound of claim 7 wherein J is J₇or J₈.
 12. A compound of claim 7 wherein J is J₉ or J₁₀.
 13. A compoundof claim 7 wherein J is J₁₁ or J₁₂.
 14. A compound of claim 7 wherein Jis J₁₃ or J₁₄.
 15. A compound of claim 7 wherein J is J₁₅.
 16. Acompound of claim 7 wherein J is J₂₃.
 17. A compound of claim 7 whereinJ is J₂₅.
 18. A compound of claim 7 where J is J₂₇.
 19. A compound ofclaim 7 wherein J is J₃₅, J₃₇ or J₃₉.
 20. A compound of claim 7 where Jis J₄₁.
 21. A compound of claim 7 wherein J is J₆₉ or J₇₁.
 22. Acompound of claim 7 wherein J is J₇₉.
 23. A compound of claim 7 whereinJ is J₈₇.
 24. A compound of claim 7 where J is J₉₅.
 25. A compound ofclaim 7 wherein J is J₁₀₅ or J₁₀₆.
 26. A compound of claim 7 where J isJ₁₂₇ or J₁₂₉.
 27. A compounds of claim 7 wherein J is J₁₃₁ or J₁₃₃. 28.A compound of claim 1 which isN-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]6,7-dihydro-5H-thieno[3,2-B]thiopyran-3-sulfonamide,4,4-dioxide.
 29. A compound of claim 1 which isN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-6,7-dihydro-5H-thieno[3,2-B]thiopyran-3-sulfonamide,4,4-dioxide.
 30. A compound of claim 1 which isN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-5,6-dihydro-5-methylthieno[3,2-B]-thiophene-3-sulfonamide-4,4-dioxide.31. A compound of claim 1 which isN-[(4-chloro-6-methoxypyrimidin-2-yl)aminocarbonyl]5,6-dihydro-5-methylthieno[3,2-B]-thiophene-3-sulfonamide-4,4-dioxide.32. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 1and at least one of the following: surfactant, solid or liquid diluent.33. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 2and at least one of the following: surfactant, solid or liquid diluent.34. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 3and at least one of the following: surfactant, solid or liquid diluent.35. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 4and at least one of the following: surfactant, solid or liquid diluent.36. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 5and at least one of the following: surfactant, solid or liquid diluent.37. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 6and at least one of the following: surfactant, solid or liquid diluent.38. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of a compound of claim 7and at least one of the following: surfactant, solid or liquid diluent.39. A composition suitable for controlling the growth of undesiredvegetation which comprises an effective amount of the compound of claim8 and at least one of the following: surfactant, solid or liquiddiluent.
 40. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 9 and at least one of the following: surfactant, solid orliquid diluent.
 41. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 10 and at least one of the following: surfactant, solid orliquid diluent.
 42. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 11 and at least one of the following: surfactant, solid orliquid diluent.
 43. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 12 and at least one of the following: surfactant, solid orliquid diluent.
 44. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 13 and at least one of the following: surfactant, solid orliquid diluent.
 45. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 14 and at least one of the following: surfactant, solid orliquid diluent.
 46. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 15 and at least one of the following: surfactant, solid orliquid diluent.
 47. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of the compoundof claim 16 and at least one of the following: surfactant, solid orliquid diluent.
 48. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 17 and at least one of the following: surfactant, solid orliquid diluent.
 49. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 18 and at least one of the following: surfactant, solid orliquid diluent.
 50. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 19 and at least one of the following: surfactant, solid orliquid diluent.
 51. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 20 and at least one of the following: surfactant, solid orliquid diluent.
 52. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 21 and at least one of the following: surfactant, solid orliquid diluent.
 53. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 22 and at least one of the following: surfactant, solid orliquid diluent.
 54. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 23 and at least one of the following: surfactant, solid orliquid diluent.
 55. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of the compoundof claim 24 and at least one of the following: surfactant, solid orliquid diluent.
 56. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 25 and at least one of the following: surfactant, solid orliquid diluent.
 57. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 26 and at least one of the following: surfactant, solid orliquid diluent.
 58. A composition suitable for controlling the growth ofundesired vegetation which comprises an effective amount of a compoundof claim 27 and at least one of the following: surfactant, solid orliquid diluent.
 59. A method for controlling the growth of undesiredvegetation which comprises applying to the locus to be protected aneffective amount of a compound of claim
 1. 60. A method for controllingthe growth of undesired vegetation which comprises applying to the locusto be protected an effective amount of a compound of claim
 2. 61. Amethod for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 3. 62. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 4. 63. A method forcontrolling the growth of undesired vegetation which comprises applyingto the locus to be protected an effective amount of a compound of claim5.
 64. A method for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 6. 65. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 7. 66. A method forcontrolling the growth of undesired vegetation which comprises applyingto the locus to be protected an effective amount of the compound ofclaim
 8. 67. A method for controlling the growth of undesired vegetationwhich comprises applying to the locus to be protected and effectiveamount of a compound of claim
 9. 68. A method for controlling the growthof undesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 10. 69. A methodfor controlling the growth of undesired vegetation which comprisesapplying to the locus to be protected an effective amount of a compoundof claim
 11. 70. A method for controlling the growth of undesiredvegetation which comprises applying to the locus to be protected aneffective amount of a compound of claim
 12. 71. A method for controllingthe growth of undesired vegetation which comprises applying to the locusto be protected an effective amount of a compound of claim
 13. 72. Amethod for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 14. 73. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 15. 74. A methodfor controlling the growth of undesired vegetation which comprisesapplying to the locus to be protected an effective amount of thecompound of claim
 16. 75. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 17. 76. A methodfor controlling the growth of undesired vegetation which comprisesapplying to the locus to be protected an effective amount of a compoundof claim
 18. 77. A method for controlling the growth of undesiredvegetation which comprises applying to the locus to be protected aneffective amount of a compound of claim
 19. 78. A method for controllingthe growth of undesired vegetation which comprises applying to the locusto be protected an effective amount of a compound of claim
 20. 79. Amethod for controlling the growth of undesired vegetation whichcomprises applying to the locus to be protected an effective amount of acompound of claim
 21. 80. A method for controlling the growth ofundesired vegetation which comprises applying to the locus to beprotected an effective amount of a compound of claim
 22. 81. A methodfor controlling the growth of undesired vegetation which comprisesapplying to the locus to be protected an effective amount of a compoundof claim
 23. 82. A method for controlling the growth of undesiredvegetation which comprises applying to the locus to be protected aneffective amount of the compound of claim
 24. 83. A method forcontrolling the growth of undesired vegetation which comprises applyingto the locus to be protected an effective amount of a compound of claim25.
 84. A method for controlling the growth of undesired vegetationwhich comprises applying to the locus to be protected an effectiveamount of a compound of claim
 26. 85. A method for controlling thegrowth of undesired vegetation which comprises applying to the locus tobe protected an effective amount of a compound of claim 27.